Bicyclic derivatives of hexahydroaporphine: Novel agents that lower intraocular pressure

Journal of Ocular Pharmacology and Therapeutics

Volumn 13, Issue 6, 1997, Pages 497-505

  Saha, Shankar L ^a   Zhan, Guilin ^b   Tang, Lin ^a   Opere, Catherine ^a   Roche, Edward B ^a,b   Camras, Carl B ^b   Ohia, S Edet ^a   Roche, Victoria F ^a  

^a CREIGHTON UNIVERSITY   (United States)

^b UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APOMORPHINE; BICYCLIC HEXAHYDROAPORPHINE DERIVATIVE; HEXAHYDROAPORPHINE DERIVATIVE; LEVORPHANOL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG DETERMINATION; DRUG SYNTHESIS; GLAUCOMA; INTRAOCULAR HYPOTENSION; INTRAOCULAR PRESSURE; MALE; NONHUMAN; RABBIT; TOPICAL DRUG ADMINISTRATION;

EID: 0031442176     PISSN: 10807683     EISSN: None     Source Type: Journal    
DOI: 10.1089/jop.1997.13.497     Document Type: Article

References (7)

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2. Roche, V.F., Roche, E.B., Lemcke, P.K., Wire, W.S., and Burks, T.F. Assessment of the in vivo and in vitro opioid activity of bridged hexahydroaporphine and isoquinoline molecules. J. Med. Chem., 33:245-248, 1990.
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4. Roche, V.F., Ohia, S.E., and Opere, C.A., Synthesis and intraocular pressure lowering activity of bicyclic analogs of hexahydroaporphine. Invest. Ophthalmol. Vis. Sci., 36: Abstract No. 3324, p S720, 1995.
5. Tran, N.D., Brosnahan, K.M., and Roche, V.F. Synthesis of a secondary desmethyl and a tertiary N-cyclopropylmethyl bridged hexahydroaporphine as precursors to bicyclic opioid ligands. J. Pharm. Sci., 79:1034-1037, 1990.
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