Nitric oxide synthase gene knockout mice do not become hypertensive during pregnancy

American Journal of Obstetrics and Gynecology

Volumn 185, Issue 5, 2001, Pages 1198-1203

  Shesely, Edward G ^a   Gilbert, Carrie ^a   Granderson, George ^a   Carretero, C Dolores ^a   Carretero, Oscar A ^a   Beierwaltes, William H ^a  

^a CASE WESTERN RESERVE UNIVERSITY   (United States)

Author keywords

Gene knockout; Hypertension; Isoforms; Mutant; Nitric oxide; Pregnancy

Indexed keywords

ISOENZYME; NITRIC OXIDE SYNTHASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; CONFERENCE PAPER; CONTROLLED STUDY; ENDOTHELIUM; ENZYME ACTIVITY; FEMALE; GENE TARGETING; HEART RATE; KNOCKOUT MOUSE; MATERNAL HYPERTENSION; MOUSE; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; SYSTOLIC BLOOD PRESSURE; VASODILATATION;

EID: 0035192412     PISSN: 00029378     EISSN: None     Source Type: Journal    
DOI: 10.1067/mob.2001.118142     Document Type: Article

References (25)

1. Biosynthesis and homeostatic roles of nitric oxide in the normal kidney
2. Nitric oxide: Physiology, pathophysiology and phamacology
3. Angiotensin II: Nitric oxide interaction and the distribution of blood flow
4. The physiology of normal pregnancy
5. Glomerular filtration and volume regulation in gravid animal models
6. Recent insights into the role of nitric oxide and renin-angiotensin in the pathophysiology of preeclamptic pregnancy
7. Adverse interactions between pregnancy and a new model of systemic hypertension produced by chronic blockade of endothelial derived relaxing factor (EDRF) in the rat
8. Inhibition of nitric oxide synthesis in rats during pregnancy produces signs similar to those of preeclampsia
9. Targeted disruption of the neuronal nitric oxide synthase gene
10. Mice lacking inducible nitric oxide synthase are not resistant to lipopolysaccharide-induced death
11. Elevated blood pressures in mice lacking endothelial nitric oxide synthase
12. A simple sequentially rejective multiple test procedure
13. Role of nitric oxide in pregnancy and preeclampsia
14. Circulating factors as markers and mediators of endothelial cell dysfunction in preeclampsia
15. Prolonged blockade of nitric oxide synthesis in gravid rats produces sustained hypertension, proteinuria, thrombocytopenia, and intrauterine growth retardation
16. W-nitro-L-arginine, an inhibitor of nitric oxide synthesis, increases blood pressure in rats and reverses the pregnancy-induced refractoriness to vasopressor agents
17. Hypertension in mice lacking the gene for endothelial nitric oxide synthase
18. Role of nNOS in blood pressure regulation in eNOS null mutant mice
19. The effect of chronic nitric oxide synthase inhibition on blood pressure and heart rate in unrestrained pregnant rats as recorded by telemetry
20. Evidence for peroxynitrate formation in the vasculature of women with preeclampsia
21. Differential expression of renal nitric oxide synthase isoforms during pregnancy in rats
22. Increased nitric oxide production plays a critical role in maternal blood pressure and glomerular hemodynamic adaptations to pregnancy in the rat
23. Effect of different nitric oxide synthesis (NOS) inhibitors on NO production and blood pressure (BP) in pregnancy
24. Changes in expression of the nitric oxide synthase isoforms in rat uterus and cervix during pregnancy and parturition
25. Vasodilator mechanisms in the coronary circulation of endothelial nitric oxide synthase-deficient mice