Invasiveness in vitro and biological markers in human primary glioblastomas

Journal of Neuro-Oncology

Volumn 54, Issue 1, 2001, Pages 1-8

  Didrik Laerum, O ^a,b   Nygaard, S J T ^a,c   Steine, S ^a   Mork, S J ^a   Engebraaten, O ^a,d   Peraud, A ^b   Kleihues, P ^b   Ohgaki, H ^b  

^a UNIVERSITY OF BERGEN   (Norway)

^b INTERNATIONAL AGENCY FOR RESEARCH ON CANCER   (France)

^c HAUKELAND UNIVERSITY HOSPITAL   (Norway)

^d OSLO UNIVERSITY HOSPITAL   (Norway)

Author keywords

Glioblastoma; Invasion; Organ culture

Indexed keywords

BIOLOGICAL MARKER; EPIDERMAL GROWTH FACTOR RECEPTOR;

ADULT; AGED; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN; CANCER INHIBITION; CANCER INVASION; CANCER SURVIVAL; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION FUNCTION; DISEASE MARKER; DISEASE SEVERITY; FEMALE; FETUS; GENE OVEREXPRESSION; GLIOBLASTOMA; GLIOMA CELL; HUMAN; IN VITRO STUDY; MALE; MUTATION; NONHUMAN; ORGAN CULTURE; RAT; SPHEROID CELL; TISSUE CULTURE;

ADULT; AGED; ANTIGENS, NUCLEAR; AUTORADIOGRAPHY; BRAIN NEOPLASMS; DNA MUTATIONAL ANALYSIS; DNA, NEOPLASM; EXONS; FEMALE; GENES, TUMOR SUPPRESSOR; GLIOBLASTOMA; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; NEOPLASM INVASIVENESS; NUCLEAR PROTEINS; POLYMORPHISM, SINGLE-STRANDED CONFORMATIONAL; RECEPTOR, EPIDERMAL GROWTH FACTOR; TUMOR MARKERS, BIOLOGICAL;

EID: 0035190338     PISSN: 0167594X     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1012565503958     Document Type: Article

References (33)

1. Pathology and genetics of tumours of the nervous system
2. Progression as exemplified by human astrocytic tumors
3. Overexpression of the EGF receptor and p53 mutations are mutually exclusive in the evolution of primary and secondary glioblastomas
4. Phenotype vs genotype in the evolution of astrocytic brain tumors
5. Effect of epidermal growth factor on glioma cell growth, migration, and invasion in vitro
6. Reaggregation of fetal rat brain cells in a stationary culture system. I. Methodology and cell identification
7. Glioma cell interactions with fetal rat brain aggregates in vitro and with brain tissue in vivo
8. Interaction between human brain tumour biopsies and fetal rat brain tissue in vitro
9. Glioma cell invasion visualized by scanning confocal laser microscopy in an in vitro co-culture system
10. Primitive neuroectodermal tumors after profylactic central nervous system irradiation in children. Association with activated K-ras gene
11. Mutations of the p53 gene in oral squamous-cell carcinomas from Sudanese dippers of nitrosamine-rich toombak and non-snuff-dippers from the Sudan and Scandinavia
12. p53 immunoreactivity and single-strand conformational polymorphism analysis often fail to predict p53 mutational status
13. Histopathologic and immunohistochemical prognostic factors in malignant gliomas
14. Local spread of malignant neuroepithelial tumors
15. Glioma cell invasion studied in organotypic coculture models
16. Invasion of rat neurogenic cell lines in embryonic chick heart fragments in vitro
17. Invasion of glioma cells into brain tissue in organ culture
18. Allele loss on chromosomes 10 and 17p and epidermal growth factor receptor gene amplification in human malignant astrocytoma related to prognosis
19. Genetic alterations associated with the evolution and progression of astrocytic brain tumours
20. Prognostic indicators in a range of astrocytic tumours: An immunohistochemical study with Ki-67 and p53 antibodies
21. Inhibition of epidermal growth factor receptor - Associated tyrosine kinase blocks glioblastoma invasion of the brain
22. Aberrant p53 expression does not correlate with the prognosis in anaplastic astrocytoma
23. Correlation of histologic morphology and tumor stage with molecular genetic analysis using microdissection in gastric carcinomas
24. Carcinomas of the renal pelvis associated with smoking and phenacetin abuse: p53 mutations and polymorphism of carcinogen-metabolising enzymes
25. Alterations of oncogenes, tumor suppressor genes and growth factors in hepatocellular carcinoma: With relation to tumor size and invasiveness
26. Distribution of epidermal factor receptor gene amplification in brain tumours and correlation to prognosis
27. Regulation of synoviocyte proliferation, apoptosis, and invasion by the p53 tumor suppressor gene
28. Mutual interactions between p53 and growth factors in cancer
29. Heterogeneous response to growth factors (EGF, PDGF), TGFα, bFGF, (1-2) on glioma spheroid growth, migration and invasion
30. The role of growth factors and oncogenes in tumor cell invasion
31. Dominant-negative mutations of the tumor suppressor p53 relating to early onset of glioblastoma multiforme