Effect of methylprednisolone on the kinetics of cytokines and liver function of regenerating liver in rats

Hepatology Research

Volumn 19, Issue 1, 2001, Pages 60-73

  Fujioka, Toshihiro ^a   Murakami, Masahiko ^a   Niiya, Takashi ^a   Aoki, Takeshi ^a   Murai, Noriyuki ^a   Enami, Yuta ^a   Kusano, Mitsuo ^a  

^a SHOWA UNIVERSITY   (Japan)

Author keywords

5 bromo 2 deoxyuridine (BrdU); Anti Ki 67 monoclonal antibody (MIB 5); Interleukin 6 (IL 6); Liver regeneration; Methylprednisolone (MDS); Tumor necrosis factor (TNF )

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; BROXURIDINE; CYTOKINE; HYALURONIC ACID; IMMUNOGLOBULIN G; INTERLEUKIN 6; KI 67 ANTIGEN; METHYLPREDNISOLONE; METHYLPREDNISOLONE SODIUM SUCCINATE; MONOCLONAL ANTIBODY; SERUM ALBUMIN; TUMOR NECROSIS FACTOR ALPHA;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALBUMIN BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY LABELING; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BLOOD LEVEL; BODY WEIGHT; CONTROLLED STUDY; CYTOKINE RELEASE; DRUG EFFECT; KINETICS; LIVER DYSFUNCTION; LIVER FUNCTION; LIVER REGENERATION; LIVER WEIGHT; MALE; NONHUMAN; PARTIAL HEPATECTOMY; PERIOPERATIVE PERIOD; PRIORITY JOURNAL; RAT;

EID: 0035189279     PISSN: 13866346     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1386-6346(00)00081-4     Document Type: Article

References (35)

1. Increased serum Interleukin-6 level and reduction of hepatic acute-phase response after major hepatectomy
2. Systemic and liver cytokine activation
3. Dexamethasone inhibits the proliferation of hepatocytes and oval cells but not bile duct cells in rat liver
4. Partial hepatectomy accelerates local tumor growth: Potential roles of local cytokine activation
5. Interleukin-6 as a marker of hepatic metabolism following hepatectomy
6. Liver regeneration
7. Influence of corticosteroid preoperative administration for surgical stress of the esophageal cancer patients during peri-and post-operative periods
8. Cytokine gene expression in liver following minor or major hepatectomy in rat
9. Experimental pathology of the liver
10. Ki-67 expression during rat liver regeneration after partial hepatectomy
11. Liver nonparenchymal cells are stimulated to provide Interleukin 6 for induction of the hepatic acute-phase response in endotoxemia but not in remote localized inflammation
12. Changes in immune-endocrine response after surgery
13. The natural history of the systemic inflammatory response syndrome (SIRS)
14. Antibodies to tumor necrosis factor-α inhibit liver regeneration after partial hepatectomy
15. Inhibition of tumor necrosis factor-α production retards liver regeneration after partial hepatectomy in rats
16. Augmentation of the early phase of liver regeneration after 70% partial hepatectomy in rats following selective Kupffer cell depletion
17. Tumor necrosis factor primes hepatocyte for DNA replication in the rat
18. Initiation of liver growth by tumor necrosis factor: Deficient liver regeneration in mice lacking type 1 tumor necrosis factor receptor
19. Analysis of liver regeneration in mice lacking type 1 or 2 tumor necrosis factor receptor: Requirement for type 1 but 2 receptor
20. Liver failure and defective hepatocyte regeneration in interleukin-deficient mice
21. Liver regeneration
22. Cytokine release syndrome induced by the 145-2C11 anti-CD3 monoclonal antibody in mice: Prevention by high doses of methylpredonisolone
23. Pulse methyl predn i so lone therapy reduces monocyte IL-1 production ex vivo
24. Liver regeneration
25. Morphological and functional changes in regenerating hepatocytes
26. Hyaluronic acid uptake by the isolated, perfused liver: An index of hepatic sinusoidal endothelial cell function
27. Evaluation of the functional recovery in phostate metabolism of the regenerating liver in rats by using 31RNMR
28. Serum hyaluronate reflects hepatic sinusoidal capillarization
29. Interleukin-6 as a new indicator of inflammatory status: Detection of serum levels of interleukin-6 and C-reactive protein after surgery
30. Risk factor before hepatectomy, hepatic function after hepatectomy and computed tomographic changes as indication of mortality from hepatic failure
31. The role of Interleukin-6, Interleukin-16, tumor necrosis factor-α and endotoxin in hepatic resection
32. Temporal changes in DNA and RNA synthesis in the regenerating liver of hydro-cortisone-treated rats
33. Dose-related opposite effects of hydrocortisone on hepatocyte proliferation in the rats
34. Clinical indication for the use of glucocorticoids to treat chronic obstructive pulmonary diseases
35. Editional blocking NF-κB in the liver: The good and bad news