Topical application of drugs: Mechanisms involved in chemical enhancement

Journal of Receptor and Signal Transduction Research

Volumn 21, Issue 2-3, 2001, Pages 259-286

  Bouwstra, J A ^a   Van den Bergh, B A I ^a   Suhonen, M ^a  

^a LEIDEN UNIVERSITY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

DRUG;

DRUG ABSORPTION; DRUG PENETRATION; DRUG TRANSPORT; HUMAN; LIPID COMPOSITION; REVIEW; SKIN;

ADMINISTRATION, TOPICAL; BIOLOGICAL AVAILABILITY; BIOLOGICAL TRANSPORT; BIOPHARMACEUTICS; DRUG THERAPY; HUMANS; VEHICLES;

EID: 0035189235     PISSN: 10799893     EISSN: None     Source Type: Journal    
DOI: 10.1081/RRS-100107430     Document Type: Review

References (132)

1. Stratum corneum: Biological and biochemical considerations
2. 2 transport through human skin in vitro
3. Predicting skin permeability
4. Lipid composition of cultured human keratinocytes in relation to their differentiation
5. The biochemistry and function of stratum corneum
6. Freeze fracture replication of cells of stratum corneum of human cells
7. Aspects of epidermal structure
8. Presence of intact intercellular lipid lamellae in the upper layers of the stratum corneum
9. Membranes structure in normal and essential fatty acid-deficient stratum corneum; characterization of ruthenium tetroxide staining and X-ray diffraction
10. Interactions between nanodispersions and human skin
11. Lipid and protein structures in the permeability barrier of mammalian epidermis
12. Disturbed extrusion mechanism of lamellar bodies in dry non-eczematous skin atopics
13. Studies of epidermal lipids using electron microscopy, Semin
14. Structure of lamellar lipid domains and corneocyte envelopes of murine stratum corneum. An X-ray diffraction study
15. Structural investigations of human stratum corneum by small-angle X-ray scattering
16. Lipid organization in pig stratum corneum
17. The lipid and protein structure of mouse stratum corneum: A wide and small angle diffraction study
18. Oriented structure in human stratum corneum revealed by X-ray diffraction
19. Structure of human stratum corneum as a function of temperature and hydration: A wide-angle X-ray diffraction study
20. Models of stratumcorneum intercellular membranes: 3H NMR of microscopically oriented multilayers
21. Characterization of low-temperature (i.e. <65°C) lipid transitions in human stratum corneum
22. Polymorphism in stratum corneum lipids
23. The effect of the skin penetration enhancer Azone® on fatty acid-sodium soap-water mixtures
24. Cholesterol sulfate, and fatty acids affect the skin stratumcorneum lipids organization
25. Liposomes - A selective drug delivery system for the topical route of administration. I. Lotion dosage forms
26. Liposonies - A selective drug delivery system for the topical route of administration. II. Gel dosage form
27. Mechanism of topical delivery of liposomally entrapped drags
28. Influence of liposomal drag entrapment on percutaneous absorption
29. Controlled drug release from a novel liposomal delivery system. I. Investigations of transdermal potential
30. Controlled drag release from a novel liposome delivery system. II. Transdermal delivery characteristics
31. Interactions of external lipids (lipid vesicles) with the skin
32. Topical dosage form of liposomal tetraciane: Effect of additives on the in vitro release and in vivo efficacy
33. Influence of liposomal composition on topical delivery of encapsulated cyclosporin A. I. An in vitro study using hairless mouse skin
34. Estradiol permeation from nonionic surfactant vesicles through human stratum corneum in vitro
35. Interactions of liposomes with human skin in vitro - The influence of lipid composition and structure
36. Interactions between non-ionic surfactant vesicles and human stratum corneum in vitro
37. How deep do intact liposomes penetrate into human skin?
38. Diffusion of estradiol from non-ionic surfactant vesicles through human stratum corneum in vitro
39. Transport of model drugs through skin in vitro and in vivo by means of vesicles
40. Application of vesicles to rat skin in vivo: A confocal laser scanning microscopy study
41. Corticosteroid dermal delivery with skin-lipid liposomes
42. Interactions between liposomes and stratum corneum studied by freeze substitution electron microscopy
43. Interactions of liposomes with human epidermis reconstructed in vitro
44. Dermal drug delivery by liposome encapsulation, clinical and electron microscopic studies
45. Lipid vesicles penetrate into intact skin owing to the transdermal osmotic gradients and hydration force
46. Interactions between liposomes and human skin in vitro, a confocal laser scanning microscopy study
47. The influence of particle size of liposomes on the disposition of drugs into the skin
48. Modulation of caffeine skin delivery by cartier design: Liposomes versus permeation enhancers
49. Liposome-bound cortisol: A new approach to cutaneous therapy
50. Penetration kinetics of liposomal hydrocortisone in human skin
51. Effect of liposomes on percutaneous penetration of lipophilic materials
52. Topical liposomal system for localized and controlled drug delivery
53. Targeted and sustained delivery of hydrocortisorie to normal and stratum corneum-removed skin without enhanced skin absorption using a liposome gel
54. Preservative activity and in vivo percutaneous penetration of butylparaben entrapped in liposomes
55. Percutaneous absorption of butylparaben from liposomes in vitro
56. Cutaneous bioavailability in hairless rats of tretinoin in liposomes or gel
57. Liposomes from soya phospholipids as percutaneous drug carriers
58. Liposomes from soya phospholipids as percutaneous drug carriers
59. Significance of empty liposomes alone and as drug carriers in dermatology
60. Monitoring in vivo skin hydration by liposomes using infrared spectroscopy in conjunction with tape stripping
61. Noninvasive percutaneous induction of topical analgesic by a new type of drug carrier, a prolongation of local pain insensitivity by anesthetic liposomes
62. Transfersomes-mediated transepidermal delivery improves the regio-specificity and biological activity of corticosteroids in vivo
63. Dermal insulin
64. Ultraflexible vesicles, Transfersomes, have an extremely low pore penetration resistance and transport therapeutic amounts of insulin across the intact mammalian skin
65. Transfersomes, liposomes and other lipid suspensions on the skin: Permeation enhancement, vesicle penetration, and transdermal drug delivery
66. Non-invasive administration of protein antigens: Transdermal immunization with the bovine serum albumin in transfersomes
67. Transdermal immunization with large proteins by means of ultradeformable drug carriers
68. Skin penetration by phospholipid vesicles, transfersomes, as visualized by means of confocal laser scanning microscopy
69. Non-uniform cellular packing of the stratum corneum and permeability barrier function of intact skin: A high-resolution confocal laser scanning microscopy study using highly deformable vesicles (Transfersomes)
70. Transfersomes, liposomes and other lipid suspensions on the skin: Permeation enhancement, vesicle penetration, and transdermal drug delivery
71. Application of vesicles in human skin in vitro: A confocal laser scanning microscopy study
72. Mechanism for enhancement effect of lipid disperse system on percutaneous absorption
73. Elasticity of vesicles affects hairless mouse skin structure and permeability
74. Interactions of elastic vesicles with human skin in vitro: Electron microscopy and two-photon excitation microscopy
75. Liposomes can specifically target entrapped malanin to the hair follicles in histocultured skin
76. Thermal analysis of human stratum corneum
77. Does hydration affect intercellular lipid organisation in the stratum corneum?
78. Effect of hydration upon the fluidity of intercellular membranes of stratum corneum: An EPR study
79. Characterization of low-temperature (i.e., < 65 degrees C) lipid transitions in human stratum corneum
80. Structure of fully hydrated human stratum corneum: A freeze fracture electron microscopy study
81. In vitro evaluation of a series of Azone analogs as dermal penetration enhancers. I
82. In vitro evaluation of a series of Azone analogs as dermal penetration enhancers. II. (Thio)amides
83. Skin penetration enhancement
84. Enhancement of naloxone penetration through human skin in vitro using fatty acids, fatty alcohols, surfactants, sulfoxides and amides
85. Structure/effect studies of fatty acid isomers as skin penetration enhancers and skin irritants
86. Increased skin permeability for lipophilic molecules
87. Effect of primary alcohols on percutaneous absorption
88. Mechanism of enhancement of percutaneous absorption of molsidomine by oleic acid
89. Facilitated transfer of cationic drugs across a lipoidal membrane by oleic acid and lauric acid
90. Role of stratum corneum lipids fluidity in transdermal drug flux
91. Oleic acid concentration and effect in human stratum corneum: Noninvasive determination by attenuated total reflectance infrared spectroscopy in vivo
92. Oleic acid: Its effects on stratum corneum in relation to transdermal drug delivery
93. Evidence that oleic acid exists as a separate phase within stratum corneum
94. Mechanism of skin penetration enhancement, in vivo, in man
95. Effects of oleic acid on human transepidermal water loss using ethanol or propylene glycol as vehicles
96. Mode of action of penetration enhancers in human skin
97. In vitro human skin barrier perturbation by oleic acid: Thermal analysis and freeze fracture electron microscopy
98. Effect of oleic acid on human epidermis: Fluorescence spectroscopic investigation
99. Mechanism for the enhancement effect of fatty acids on the percutaneous absorption of propranolol
100. Enhancement of naloxone penetration through human skin in vitro using fatty acids, fatty alcohols, surfactants, sulphoxides and amides
101. Skin permeation enhancement of tegafur by ethanol/panasate 800 or ethanol/water binary vehicle and combined effect of fatty acids and fatty alcohols
102. Effect of fatty acids, fatty amines and propylene glycol on rat stratum corneum lipids and proteins in vitro measured by Fourier Transformed Infrared/Attenuated Total Reflectance spectroscopy
103. In vitro human skin barrier modulation by fatty acids: Skin permeation and thermal analysis studies
104. Azone - A new non-toxic enhancer for cutaneous penetration
105. Transdermal penetration of vasopressin. II: The influence of Azone in in vitro and in vivo penetration
106. Disposition and metabolic profiling of the penetration enhancer Azone. I. In vivo studies urinary profiles of hamster, rat, monkey, and man
107. 2 agonist MN-0923 in freely moving rats
108. Influence of various penetration enhancers on the in vitro permeation of amino acids across hairless mouse skin
109. Effect of the absorption enhancer azone on the transport of 5 fluorouracil across hairless rat skin
110. Vehicle effect on topical drug delivery. III. Effect of azon on the cutaneous permeation of metronidazole and propylene glycol
111. The influence of azone, propylene glycol and polyethylene glycol on in vitro skin penetration of trifluorothymidine
112. Skin penetration enhancement
113. Kinetics, ultrastructural aspects and molecular modelling of transdermal peptide flux enhancement by N-alkylazacycloheptanones
114. Mixed monolayers of dipalmitoylphosphatidylcholine with Azone or oleic acid at the air-water interface
115. 2; transport through intercellular space versus cellular uptake through desmosomes
116. 2 transport through human skin
117. A two-chambered diffusion cell with improved flow through characteristics through for studying the drug permeation of biological membranes
118. Effect of N-alkyl-azocycloheptan-2-ones including azone on the thermal behaviour of human stratum corneum
119. The influence of N-alkyl-azones on the ordering of the lamellae in human stratum corneum, as determined by small angle x-ray diffraction
120. Changes in lipid organisation of the skin barrier by N-alkyl-azocycloheptanones: A visualisation and X-ray diffraction study
121. 2H NMR and freeze fracture electron microscopy reveal rapid isotropic motion and lipid perturbation by azone in human stratum corneum
122. Enhancement of propranolol hydrochlodde and diazepam skin absorption in vitro: Effect of enhancer lipophilicity
123. The enhancement index concept applied to terpene penetration enhancers for human skin and model lipophilic (oestradiol) and hydrophylic (5-fluorouracil) drugs
124. Terpenes and the lipid-protein partitioning theory of skin penetration enhancement
125. Effect of limonene and related compounds on the percutaneous absorption of indomethacine
126. Enhanced penetration of mytomicin C through hairless mouse and rat skin by enhancers with terpene moieties
127. Small angle X-ray diffraction investigations on the lipid barrier in human skin
128. Wide-angle x-ray diffraction of human stratum corneum: Effect of hydration and terpene enhancer treatment