The selection of a commercial route for the D1 antagonist Sch-39166

Current Opinion in Drug Discovery and Development

Volumn 4, Issue 6, 2001, Pages 792-799

  Hou, D ^a   Schumacher, D ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Aziridinium opening; Commercial route; D1 antagonist; Sch 39166; Selection process

Indexed keywords

AZIRIDINE DERIVATIVE; DOPAMINE 1 RECEPTOR BLOCKING AGENT; ECOPIPAM; PHENYLALANINE DERIVATIVE; PROPANEDIOL DERIVATIVE; TETRALIN DERIVATIVE; UNCLASSIFIED DRUG;

CHEMICAL MODIFICATION; COST; DRUG SYNTHESIS; EPOXIDATION; INTERMETHOD COMPARISON; REACTION ANALYSIS; REDUCTION; REVIEW; TECHNIQUE;

BENZAZEPINES; DOPAMINE ANTAGONISTS; DRUG INDUSTRY; INDICATORS AND REAGENTS; RECEPTORS, DOPAMINE D1;

EID: 0035185399     PISSN: 13676733     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (14)

1. Dopamine D1-receptor binding in the living human brain
2. Synthesis and receptor affinities of some conformationally restricted analogues of the dopamine D1 selective ligand (5R)-8-chloro-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1 H-3-benzazepin-7-ol
3. Pharmacological profile of Sch 39166: A dopamine D1 selective benzonaphthazepine with potential antipsychotic activity
4. Lack of apparent antipsychotic effect of the D1-dopamine receptor antagonist Sch 39166 in acutely ill schizophrenic patients
5. Differential effects of the D1-DA receptor antagonist Sch 39166 on positive and negative symptoms of schizophrenia
6. An open trial of the D1 antagonist Sch 39166 in six cases of acute psychotic states
7. Ecopipam (Sch 39166), a D1 antagonist, on acute effects of cocaine
8. Attenuation of the euphoric effects of cocaine by the dopamine D1/D5 antagonist Ecopipam (Sch 39166)
9. Acute deleterious effects of cocaine on cardiac conduction, hemodynamics, and ventricular fibrillation threshold: Effects of interaction with a selective dopamine D1 antagonist Sch 39166
10. Amino diol based asymmetric syntheses of a fused benzazepine as a selective D1 dopamine receptor
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12. Novel stereoselective syntheses of the fused benzazepine dopamine D1 antagonist (6aS, 13bR)-11-chloro-6,6a,7,8,9,13b-hexahydro-7-methyl-5H- benzo[d]naphth[2,1-b]azepin-12-ol (Sch 39166): 1. Aziridinium salt based syntheses
13. Asymmetric olefin epoxidation with sodium hypochlorite catalyzed by easily prepared chiral manganese (III) salen complexes
14. Kinetic resolution of 1,2-dihydronaphthalene oxide and related epoxides via asymmetric C-H hydroxylation