GnRH analogues: Recent developments

Infertility and Reproductive Medicine Clinics of North America

Volumn 12, Issue 1, 2001, Pages 233-245

  Rivier, J ^a  

^a SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 (N BENZYL N METHYLAMINOMETHYL) 7 (2,6 DIFLUOROBENZYL) 4,7 DIHYDRO 2 (4 ISOBUTYRYLAMINOPHENYL) 4 OXOTHIENO[2,3 B]PYRIDINE 5 CARBOXYLIC ACID ISOPROPYL ESTER; A 75998; ABARELIX; AZALINE B; CETRORELIX; FE 200486; GANIRELIX; GONADORELIN AGONIST; GONADORELIN ANTAGONIST; GONADORELIN DERIVATIVE; HISTRELIN; ITURELIX; LEUPRORELIN; TEVERELIX; TRIPTORELIN; UNCLASSIFIED DRUG;

DRUG DELIVERY SYSTEM; DRUG EFFECT; DRUG EFFICACY; DRUG FORMULATION; DRUG RESEARCH; DRUG SAFETY; DRUG SOLUBILITY; DRUG STRUCTURE; REVIEW; SUSTAINED RELEASE PREPARATION;

EID: 0035182574     PISSN: 10479422     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (58)

1. New antagonists of LHRH. II. Inhibition and potentiation of LHRH by closely related analogues
2. Functional microdomains in G-protein-coupled receptors: The conserved arginine-cage motif in the gonadotropin-releasing hormone receptor
3. Nuclear magnetic resonance analysis and conformational characterization of a cyclic decapeptide antagonist of gonadotropin-releasing hormone
4. 6 and exogenous LHRH
5. Conformational analysis of a highly potent dicyclic gonadotropin-releasing hormone antagonist by nuclear magnetic resonance and molecular dynamics
6. Long-lasting suppression of plasma testosterone by Antarelix-Depot: A sustained release preparation of the superantagonist teverelix
7. Pharmacological profile of FE200486, a potent, water soluble and long acting GnRH antagonist
8. Primary structure of the ovine hypothalamic luteinizing hormone-releasing factor (LRF)
9. The dynamics of gonadotropin inhibition in women induced by an antagonistic analogue of gonadotropin-releasing hormone
10. Cloning and characterization of the human GnRH receptor
11. Discovery of a novel, potent, and orally active nonpeptide antagonist of the human luteinizing hormone-releasing hormone (LHRH) receptor
12. Inhibition of the preovulatory proestrous gonadotropin surge, ovulation and pregnancy with a peptide analogue of luteinizing hormone-releasing hormone
13. Physiology and contraceptive effects of LHRH and agonistic analogs in female animals
14. Analogs of luteinizing hormone-releasing hormone with increased biological activity produced by D-amino acid substitutions in position 6
15. Antarelix (EP 24332) a novel water soluble LHRH antagonist
16. Treatment with GnRH analogs: Controversies and perspectives
17. Structure-activity relationships in the C-terminal part of luteinizing hormone-releasing hormone (LH-RH)
18. Further studies on the structure-activity relationships in the C-terminal part of luteinizing hormone-releasing hormone
19. Natural cytotoxicity and GnRH agonist administration in advanced endometriosis: Positive modulation on natural killer activity
20. Evidence of differential control of FSH and LH secretion by gonadotropin-releasing hormone (GnRH) from the use of a GnRH antagonist
21. Cytotoxic analogs of luteinizing hormone-releasing hormone bind with high affinity to human breast cancers
22. 5 substitution in luteinizing hormone-releasing hormone antagonists
23. Clinical pharmacology of azaline B
24. Novel, water soluble and long acting GnRH antagonists
25. Cloning, sequencing, and expression of human gonadotropin releasing hormone (GnRH) receptor
26. The development of safer GnRH antagonists: Strategy and status
27. GnRH analog design structure-function studies toward the development of agonists and antagonists: Rationale and perspective
28. Consensus bioactive conformation of cyclic GnRH antagonists defined by NMR and molecular modeling
29. Recovery of pituitary function after treatment with a targeted cytotoxic analog of luteinizing hormone-releasing hormone
30. Antide and related antagonists of luteinizing hormone release with long action and oral activity
31. Future trends in infertility treatment: Challenges ahead
32. Structure of the porcine LH- and FSH-releasing hormone. I. The proposed amino acid sequence
33. Pharmacology and pharmacokinetics of abarelix-depot, a novel, long-acting formulation of the GnRH antagonist abarelix
34. Suppression of plasma gonadotropins by abarelix, a potent new LHRH antagonist
35. Synthetic analogs of the hypothalamic luteinizing hormone releasing factor with increased agonist or antagonist properties
36. 66 chimeric toxin through specific gonadotropin-releasing hormone binding sites
37. Potent, long-acting luteinizing hormone-releasing hormone antagonists containing new synthetic amino acids: N,N′-dialkyl-D-homoarginines
38. Inhibition of ovulation in women by chronic treatment with a stimulatory LRH analogue - A new approach to birth control?
39. The half-life, metabolism and excretion of tritiated luteinizing hormone (LHRH) in man
40. Effects of gonadotropin-releasing hormone/agonists and antagonists on reproductive functions
41. Novel antagonists of GnRH: A compendium of their physicochemical properties, activities, relative potencies and efficacy in humans
42. GnRH analogues towards the next millenium
43. Solid-phase peptide synthesis on a benzhydrylamine resin of LRF (luteinizing hormone releasing factor) and analogues, including antagonists
44. Gonadotropin-releasing hormone antagonists with Nω-triazolyl-ornithine-lysine or -para-aminophenylalanine residues at positions 5 and 6
45. New effective gonadotropin-releasing hormone antagonists with minimal potency for histamine release in vitro
46. GnRH analogs structure-activity relationships
47. Conformational analysis of a highly potent, constrained gonadotropin-releasing hormone antagonist. II. Molecular dynamics simulations
48. Conformational analysis of a highly potent, constrained gonadotropin-releasing hormone antagonist. I. Nuclear magnetic resonance
49. A novel conformation in a highly potent, constrained gonadotropin-releasing hormone antagonist
50. Recent approaches to fertility control based on derivatives of LH-RH
51. Molecular mechanisms of ligand interaction with the gonadotropin-releasing hormone receptor
52. Synthesis of the luteinizing releasing hormone of the hypothalamus and its hormonal activity
53. LHRH antagonists: Antifertility effect and other adverse responses
54. Regulatory peptides of the hypothalamus
55. 10] LH-RH ethylamide