Brief communication: Delivery of a hammerhead ribozyme specifically downregulates mutant type I collagen mRNA in a murine model of osteogenesis imperfecta

Antisense and Nucleic Acid Drug Development

Volumn 11, Issue 5, 2001, Pages 341-346

  Toudjarska, I ^a   Kilpatrick, M W ^a   Niu, J ^a,b   Wenstrup, R J ^c   Tsipouras, P ^a  

^a UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

^b JILIN UNIVERSITY   (China)

^c CINCINNATI CHILDREN S HOSPITAL RESEARCH FOUNDATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN TYPE 1; HAMMERHEAD RIBOZYME; MESSENGER RNA; RIBOZYME; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CALVARIA; CLINICAL FEATURE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG DELIVERY SYSTEM; GENE CONTROL; GENE EXPRESSION; GENE MUTATION; GENE TARGETING; MOUSE; NONHUMAN; OSTEOBLAST; OSTEOGENESIS IMPERFECTA; PATHOPHYSIOLOGY; PRIORITY JOURNAL; ANIMAL; CELL STRAIN 3T3; CHEMISTRY; DISEASE MODEL; DOWN REGULATION; DRUG EFFECT; GENETIC TRANSCRIPTION; GENETICS; NUCLEOTIDE SEQUENCE;

ANIMALIA; MURINAE;

3T3 CELLS; ANIMAL; BASE SEQUENCE; COLLAGEN TYPE I; DISEASE MODELS, ANIMAL; DOWN-REGULATION; MICE; OSTEOGENESIS IMPERFECTA; RNA, CATALYTIC; RNA, MESSENGER; SUPPORT, NON-U.S. GOV'T; TRANSCRIPTION, GENETIC;

EID: 0035181561     PISSN: 10872906     EISSN: None     Source Type: Journal    
DOI: 10.1089/108729001753231722     Document Type: Article

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