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Volumn 23, Issue 6, 2001, Pages 698-708

Pyrrolizidine poisoning: A neglected area in human toxicology

Author keywords

Herbal medicine; Human poisoning; Pyrrolizidine alkaloids

Indexed keywords

PLANT TOXIN; PYRROLIZIDINE;

EID: 0035178817     PISSN: 01634356     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007691-200112000-00018     Document Type: Article
Times cited : (49)

References (176)
  • 1
    • 0019061838 scopus 로고
    • Herbal teas and toxins: Novel aspects of pyrrolizidine poisoning in the United States
    • (1990) Perspect Biol Med , vol.24 , pp. 1-14
    • Huxtable, R.1
  • 9
    • 0019061838 scopus 로고
    • Herbal teas and toxins: Novel aspects of pyrrolizidine poisoning in the United states
    • (1980) Persp Biol Med , vol.24 , pp. 1-14
    • Huxtable, R.1
  • 19
    • 12444281201 scopus 로고
    • The chronic pathological effects on the liver of the rat of the pyrrolizidine alkaloids heliotrine, lasiocarpine nd their N-oxides
    • (1959) J Pathol Bacteriol , vol.78 , pp. 483-502
    • Bull, L.B.1    Dick, A.T.2
  • 30
    • 0014354761 scopus 로고
    • Toxicity and carcinogenic action of pyrrolizidine alkaloids
    • (1968) Cancer Res , vol.28 , pp. 2237-2246
    • Schoental, R.1
  • 35
    • 0018170660 scopus 로고
    • Pyrrolizidine (Senecio) intoxication mimicking Reyes syndrome
    • (1978) J Paediatr , vol.93 , pp. 980-982
    • Fox, D.1
  • 39
    • 0021942162 scopus 로고
    • Herbal tea induced hepatic venoocclusive disease: Quantification of toxic alkaloid exposure in adults
    • (1985) Gut , vol.26 , pp. 101-104
    • Kumana, C.1    Ng, M.2    Lin, H.3
  • 42
    • 0006737766 scopus 로고
    • Veno-occlusive disease in children in Barbados asssociated with the drinking of herb teas made from Crotalaria plants
    • (1956) West Ind Med J , vol.5 , pp. 33-36
    • Stuart, K.1    Bras, G.2
  • 54
    • 0020642907 scopus 로고
    • Estimated intakes of pyrrolizidine alkaloids by humans. A comparison with the dose rates causing tumours in rats
    • (1983) J Toxicol Environ Health , vol.11 , pp. 625-635
    • Culvenor, C.1
  • 55
    • 0024239892 scopus 로고
    • Comfrey: Assessing the low dose health risk
    • (1988) Med J Aust , vol.149 , pp. 678-682
    • Abbott, P.1
  • 58
    • 0001104144 scopus 로고
    • The Pyrrolizidine alkaloids
    • Manske R, ed. New York: Academic Press
    • (1978) The alkaloids , pp. 246-324
    • Warren, F.1
  • 65
    • 4243224498 scopus 로고
    • The Senecio alkaloids. Part VI. The isomerisation of senecic acid to trans-senecic (integerrinecic) acid, and the general structure of the 'necic' acids
    • (1950) J Chem Soc , pp. 700-702
    • Kropman, M.1    Warren, F.L.2
  • 67
  • 71
    • 0000032466 scopus 로고
    • Kwashiorkor like syndrome and other pathological changes in rats as a result of feeding with Senecio alkaloids (Isatidine)
    • (1955) Voeding , vol.16 , pp. 268-285
    • Schoental, R.1
  • 75
    • 0024078378 scopus 로고
    • Toxicity and metabolism of pyrrolizidine alkaloids
    • (1988) J Anim Sci , vol.66 , pp. 2343-2350
    • Cheeke, P.1
  • 78
    • 0026782361 scopus 로고
    • Detection of sulphur-conjugated pyrrolic metabolites in blood and fresh or fixed liver tissue from rats given a variety of toxic pyrrolizidine alkaloids
    • (1992) Toxicol Lett , vol.63 , pp. 47-55
    • Mattocks, A.1    Jukes, R.2
  • 80
    • 0025093061 scopus 로고
    • N-acetyl cysteine conjugated pyrrole identified in rat urine following administration of two pyrrolizidine alkaloids, monocrotaline and senecionine
    • (1990) Toxicol Lett , vol.54 , pp. 61-69
    • Estep, J.1    Lame, M.2    Jones, A.3
  • 85
    • 0020003087 scopus 로고
    • Alkylation of N2 in deoxyguanosine by dehydroretronecine, a carcinogenic metabolite of the pyrrolizidine alkaloid monocrotaline
    • (1982) Cancer Res , vol.42 , pp. 8-14
    • Robertson, K.1
  • 88
    • 0028985270 scopus 로고
    • The relationship between the concentration of the pyrrolizidine alkaloid monocrotaline and the pattern of metabolites released from the isolated liver
    • (1995) Toxicol Appl Pharmacol , vol.130 , pp. 1-8
    • Yan, C.C.1    Huxtable, R.J.2
  • 90
    • 0028985270 scopus 로고
    • The relationship between the concentration of the pyrrolizidine alkaloid monocrotaline and the pattern of metabolites released from the isolated liver
    • (1995) Toxicol Appl Pharmacol , vol.130 , pp. 1-8
    • Yan, C.1    Huxtable, R.2
  • 91
    • 0028840168 scopus 로고
    • Relationship between glutathione concentration and metabolism of the pyrrolizidine alkaloid, monocrotaline, in the isolated, perfused liver
    • (1995) Toxicol Appl Pharmacol , vol.130 , pp. 132-139
    • Yan, C.1    Huxtable, R.2
  • 92
    • 0031913915 scopus 로고    scopus 로고
    • Microsomal formation of a pyrrolic alcohol glutathione conjugate of clivorine. Firm evidence for the formation of a pyrrolic metabolite of an otonecine-type pyrrolizidine alkaloid
    • (1998) Drug Metab Dispos , vol.26 , pp. 181-184
    • Lin, G.1    Cui, Y.2    Hawes, E.3
  • 94
    • 0006748759 scopus 로고
    • Excretion and alteration of monocrotaline in rats
    • (1966) Fed Proc , vol.25 , pp. 688-691
    • Hayashi, Y.1
  • 97
    • 0002208637 scopus 로고
    • Autonomous phlebitis obliterans of the main stem of the hepatic vein as a cause of death
    • (1899) Beitr Pathol Anat , vol.26 , pp. 1-18
    • Chiari, H.1
  • 100
    • 0015519892 scopus 로고
    • Senecio species: Toxic plants used as food and medicine in Transkei
    • (1972) S Afr Med J , vol.46 , pp. 1039-1043
    • Rose, E.F.1
  • 101
    • 0001117370 scopus 로고
    • Further observations on subacute and chronic liver changes in rats after a single dose of various pyrrolizidine (Senecio) alkaloids
    • (1959) J Pathol Bacteriol , vol.78 , pp. 471-482
    • Schoental, R.1    Magee, P.2
  • 106
    • 0015418011 scopus 로고
    • Effect of age on the development of cor pulmonale in non-human primates following pyrrolizidine alkaloid intoxication
    • (1972) Exp Mol Pathol , vol.17 , pp. 220-232
    • Allen, J.1    Chesney, C.2
  • 109
  • 113
    • 0001522437 scopus 로고
    • Effects of whole-body irradiation, and of partial hepatectomy, on the liver lesions induced in rats by a single dose of retrorsine, a pyrrolizidine (Senecio) alkaloid
    • (1963) Br J Cancer , vol.17 , pp. 242-251
    • Schoental, R.1    Bensted, J.P.M.2
  • 124
    • 0006648451 scopus 로고
    • Chromosomal breakage by pyrrolizidine alkaloids and modification of the effect by Cysteine
    • (1961) Caryologia , vol.14 , pp. 251-261
    • Avanzi, S.1
  • 126
    • 70449302347 scopus 로고
    • The effects of Senecio alkaloid (monocrotaline) on human embryo liver in tissue culture
    • (1960) Br J Cancer , vol.14 , pp. 537-546
    • Hirchinson, V.1
  • 131
    • 0016604794 scopus 로고
    • Localization in the cell cycle of the antimitotic action of the pyrrolizidine alkaloid, lasiocarpine and its metabolite, dehydroheliotridine
    • (1975) Chem Biol Interact , vol.10 , pp. 185-197
    • Samuel, A.1    Jago, M.V.2
  • 140
    • 0018637656 scopus 로고
    • Preparative isolation of pyrrolizidine alkaloids derived from Senecio vulgaris
    • (1979) J Liq Chromatogr , vol.2 , pp. 1319-1323
    • Segall, H.1
  • 143
    • 0014333889 scopus 로고
    • Spectrophotometric determination of pyrrolizidine alkaloids-some improvements
    • (1968) Anal Chem , vol.40 , pp. 1749-1750
    • Mattocks, A.1
  • 147
    • 0014075238 scopus 로고
    • Detection of pyrrolizidine alkaloids on thin layer chromatograms
    • (1967) J Chromatogr , vol.27 , pp. 505-508
    • Mattocks, A.1
  • 157
    • 0017849116 scopus 로고
    • Rapid isolation and identification of pyrollizidine alkaloids (senecio vulgaris) by use of high performance liquid chromatography
    • (1978) J Chromatogr , vol.150 , pp. 202-206
    • Qualls, C.1    Segall, H.2
  • 158
    • 0018828693 scopus 로고
    • Rapid high-performance liquid chromatography isolation of monoesters, diesters and macrocyclic diester pyrrolizidine alkaloids from Senecio jacobaea and Amsinckia intermedia
    • (1980) J Chromatogr , vol.192 , pp. 474-478
    • Dimenna, G.P.1    Krick, T.P.2    Segall, H.J.3
  • 159
    • 49049147425 scopus 로고
    • High-performance liquid chromatographic analysis of pyrrolizidine (Senecio) alkaloids using a reverse-phase styrene-divinylbenzene resin column
    • (1981) J Chromatogr , vol.210 , pp. 1548
    • Ramsdell, H.S.1    Buhler, D.R.2
  • 160
    • 0022580375 scopus 로고
    • Method for determination of pyrrolizidine alkaloids and their metabolites by high-performance liquid chromatography
    • (1986) Anal Biochem , vol.152 , pp. 59-65
    • Kedzierski, B.1    Buhler, D.2
  • 162
    • 0034595550 scopus 로고    scopus 로고
    • On-line identification of phytochemical constituents in botanical extracts by combined high-performance liquid chromatographic-diode array detection mass spectrometric techniques
    • (2000) J Chromatogr A , vol.880 , pp. 203-232
    • He, X.1
  • 163
  • 164
    • 0032878193 scopus 로고    scopus 로고
    • Poisoning by plant material: Review of human cases and analytical determination of main toxins by highperformance liquid chromatography-(tandem) mass spectrometry
    • (1999) J Chromatogr B , vol.733 , pp. 181-229
    • Gaillard, Y.1    Pepin, G.2
  • 165
    • 0030091674 scopus 로고    scopus 로고
    • Enzyme-linked immunosorbent assay detection of pyrrolizidine alkaloids: Immunogens based on quaternary pyrrolizidinium salts
    • (1996) Bioconjug Chem , vol.7 , pp. 187-195
    • Roseman, D.1    Wu, X.2    Kurth, M.3
  • 167
    • 0024441093 scopus 로고
    • A competitive enzyme linked immunosorbent assay (ELISA) to detect retronecine and monocrotaline in vitro
    • (1989) Toxicon , vol.27 , pp. 1059-1064
    • Bober, M.1    Milco, L.2    Miller, R.3
  • 169
    • 0029101869 scopus 로고
    • Analysis of pyrrolizidine alkaloids: A competitive enzyme-linked immunoassay (ELISA) for the quantitative determination of some toxic pyrrolizidine alkaloids
    • (1995) Nat Toxins , vol.3 , pp. 305-309
    • Roeder, E.1    Pflueger, T.2
  • 172
    • 0024968152 scopus 로고
    • Comparison of capillary gas chromatography with IH and 13C nuclear magnetic resonance spectroscopy for the quantitation of pyrrolizidine alkaloids from Senecio vernalis
    • (1989) J Chromatogr , vol.462 , pp. 387-391
    • Pieters, L.1    Hartmann, T.2    Janssens, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.