GC/MS/MS detection of pyrrolic metabolites in animals poisoned with the pyrrolizidine alkaloid riddelliine

Journal of Natural Toxins

Volumn 9, Issue 2, 2000, Pages 197-206

  Schoch, Thomas K ^a   Gardner, Dale R ^a   Stegelmeier, Bryan L ^a  

^a AGRICULTURAL RESEARCH SERVICE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PLANT EXTRACT; PYRROLIZIDINE ALKALOID; RIDDELLIINE N OXIDE; RIDDELLIINE N-OXIDE; RIDDELLINE;

ANIMAL; ARTICLE; CATTLE; CHEMICAL MODEL; CHEMISTRY; ISOLATION AND PURIFICATION; LIVER; MASS FRAGMENTOGRAPHY; MASS SPECTROMETRY; METABOLISM; METHODOLOGY; SWINE;

ANIMALS; CATTLE; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; LIVER; MASS SPECTROMETRY; MODELS, CHEMICAL; PLANT EXTRACTS; PYRROLIZIDINE ALKALOIDS; SWINE;

ANIMALIA; BOS TAURUS; BOVINAE; SENECIO RIDDELLII; SUS SCROFA;

EID: 0034079849     PISSN: 10588108     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. Culvenor, C. C. J., Edgar, J. A., Smith, L. W., and Tweeddale, H. J. (1970). Dihydropyrrolizines: III. Preparation and reactions of derivatives related to pyrrolizidine alkaloids. Aust. J. Chem. 23, 1853-1897.
2. Johnson, A. E., Molyneux, R. J. (1984). Toxicity of threadleaf groundsel (Senecio douglasii var. Iongilobus) to cattle. Am. J. Vet. Res. 45, 26-31.
3. Johnson, A. E., Molyneux, R. J., and Stuart, L. D. (1985). Toxicity of Riddell's groundsel (Scenecio riddellii) to cattle. Am. J. Vet. Res. 46, 577-582.
4. Lanigan, G. W. (1970). Metabolism of pyrrolizidine alkaloids in the ovine rumen: II. Some factors affecting rate of alkaloid breakdown by rumen fluid in vitro. Aust. J. Agr. Res. 21, 633-639.
5. Mattocks, A. R. (1968). Toxicity of pyrrolizidine alkaloids. Nature 217, 723.
6. Mattocks, A. R. (1986). Chemistry and Toxicology of Pyrrolizidine Alkaloids, pp. 171-172, 210-212. Academic Press, Inc., London.
7. Mattocks, A. R., and Jukes, R. (1990). Recovery of the pyrrolic nucleus of pyrrolizidine alkaloid metabolites from sulphur conjugates in tissues and body fluids. Chem. Biol. Interact. 75, 225-239.
8. Mattocks, A. R., and Jukes, R. (1992). Detection of sulphur-conjugated pyrrolic metabolites in blood and fresh or fixed liver tissue from rats given a variety of toxic pyrrolizidine alkaloids. Toxicol. Lett. 63, 47-55.
9. Mattocks, A. R., Jukes, R., and Brown, J. (1989). Simple procedures for preparing putative toxic metabolites of pyrrolizidinc alkaloids. Toxicon 27, 561-567.
10. Mattocks, A. R., and White, I. N. H. (1970). Estimation of metabolites of pyrrolizidine alkaloids in animal tissues. Anal. Biochem. 38, 529-535.
11. Molyneux, R. J., Johnson, A. E., Olsen, J. D., and Baker, D. C. (1991). Toxicity of pyrrolizidine alkaloids from Riddell's groundsel (Senecio riddellii) to cattle. Am. J. Vet. .Res. 52, 146-151.
12. Molyneux, R. J., Johnson, A. E., and Stuart, L. D. (1988). Delayed manifestation of Senecio-induced pyrrolizidine alkaloidosis in cattle: Case reports. Vet. Hum. Toxicol. 30, 201-205.
13. Prakash, A. S., Pereira, T. N., Reilly, P. E. B., and Seawright, A. A. (1999). Pyrrolizidine alkaloids in human diet. Mut. Res. 443, 53-67.
14. Saville, B. (1962). Solvolysis of unsaturated sulfides assisted by silver ion. J. Chem. Soc., 4062-4068.
15. Seawright, A. A., Hrdlicka, J., Wright, J. D., Kerr, D. R., Mattocks, A. R., and Jukes, R. (1991). The identification of hepatotoxic pyrrolizidine alkaloid exposure in horses by the demonstration of sulphur-bound pyrrolic metabolites on their hemoglobin. Vet. Hum. Toxicol. 33, 286-287.
16. Stegelmeier, B. L., Edgar, J. A., Colegate, S. M., Gardner, D. R., Schoch, T. K., Coulombe, R. A., and Molyneux, R. J. (1999). Pyrrolizidine alkaloid plants, metabolism and toxicity. J. Nat. Toxins 8, 95-116.
17. Stegelmeier, B. L., Gardner, D. R., James, L. F., and Molyneux, R. J. (1996). Pyrrole detection and the pathologic progression of Cynoglossum officiale (houndstongue) poisoning in horses. J. Vet. Diagn. Invest. 8, 81-90.
18. Winter, H., Seawright, A. A., Hrdlicka, J., Mattocks, A. R., Jukes, R., Wangdi, K., and Gurung, K. B. (1993). Pyrrolizidine alkaloid poisoning of yaks -diagnosis of pyrrolizidine alkaloid exposure by the demonstration of sulphur-conjugated pyrrolic metabolites of the alkaloid in circulating haemoglobin. Aust. Vet. J. 70, 312-313.
19. Winter, H., Seawright, A. A., Mattocks, A. R., Jukes, R., Tshewang, U., Gurung, B. J. (1990). Pyrrolizidine alkaloid poisoning in yaks. First report and confirmation by identification of sulphur bound pyrrolic metabolites of the alkaloids in preserved liver tissue. Aust. Vet. J. 67, 411-412.