Topology of the human skeletal muscle chloride channel hCIC-1 probed with hydrophilic epitope insertion

Pflugers Archiv European Journal of Physiology

Volumn 443, Issue 2, 2001, Pages 280-288

  Kuchenbecker, Maya ^a   Schu, Bernhard ^a   Kürz, Lothar ^a   Rüdel, Reinhardt ^a  

^a UNIVERSITY OF ULM   (Germany)

Author keywords

Chloride channel; Epitope tags; Skeletal muscle; Structure function relation; Transmembrane topology

Indexed keywords

CHLORIDE CHANNEL; EPITOPE;

ARTICLE; CHLORIDE CURRENT; ELECTROPHYSIOLOGY; HUMAN; HUMAN TISSUE; HYDROPHILICITY; IMMUNOFLUORESCENCE; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN MODIFICATION; SKELETAL MUSCLE; STRUCTURE ACTIVITY RELATION;

CELL LINE, TRANSFORMED; CHLORIDE CHANNELS; ELECTRIC CONDUCTIVITY; EPITOPES; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; MUSCLE, SKELETAL; SEQUENCE TAGGED SITES; STAINING AND LABELING; TISSUE DISTRIBUTION; TRANSFECTION;

EID: 0035178204     PISSN: 00316768     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004240100688     Document Type: Article

References (43)

1. Transmembrane organization of the Na,K-ATPase determined by epitope addition
2. An aspartic acid residue important for voltage-dependent gating of human muscle chloride channels
3. Mechanism of voltage-dependent gating in skeletal muscle chloride channels
4. Mechanism of ion permeation in skeletal muscle chloride channels
5. A mutation in autosomal dominant myotonia congenita affects pore properties of the muscle chloride channel
6. Pore-forming segments in voltage-gated chloride channels
7. ClC and CFTR chloride channel gating
8. Systematic sequencing of the Escherichia coli genome: Analysis of the 2.4-4.1 min (110,917-193,643 bp) region
9. Molecular basis of Thomsen's disease (autosomal dominant myotonia congenita)
10. The GEF1 gene of Saccharomyces cerevisiae encodes an integral membrane protein; mutations in which have effects on respiration and iron-limited growth
11. Regions involved in the opening of ClC-2 chloride channel by voltage and cell volume
12. Absence of the skeletal muscle sarcolemma chloride channel ClC-1 in myotonic mice
13. 2+-activated potassium channels in human leukaemic T lymphocytes
14. A family of putative chloride channels from Arabidopsis and functional complementation of a yeast strain with a CLC gene disruption
15. Primary structure of Torpedo marmorata chloride channel isolated by expression cloning in Xenopus oocytes
16. Properties of voltage-gated chloride channels of the CIC gene family
17. The CLC chloride channel family
18. Membrane topology of P-glycoprotein as determined by epitope insertion: Transmembrane organization of the N-terminal domain of mdr3
19. Two highly homologous members of the ClC chloride channel family in both rat and human kidney
20. The skeletal muscle chloride channel in dominant and recessive human myotonia
21. - channel studied using hydrophilic epitope insertion
22. 2+ and other sulfhydryl-reactive compounds
23. 2+ blockade of the human skeletal muscle chloride channel
24. Molecular pathophysiology of voltage-gated ion channels
25. Two physically distinct pores in the dimeric ClC-0 chloride channel
26. Independent gating of single pores in CLC-0 chloride channels
27. High-level expression, functional reconstitution, and quaternary structure of a prokaryotic ClC-type chloride channel
28. Panning transfected cells for electrophysiological studies
29. Purification, reconstitution, and subunit composition of a voltage-gated chloride channel from Torpedo electroplax
30. Homodimeric architecture of a ClC-type chloride ion channel
31. Open-state substructure of single chloride channels from Torpedo electroplax
32. Projection structure of a ClC-type chloride channel at 6.5 Å resolution
33. Concentration and pH dependence of skeletal muscle chloride channel ClC-1
34. Permeation and block of the skeletal muscle chloride channel, ClC-1, by foreign anions
35. The muscle chloride channel ClC-1 has a double-barreled appearance that is differentially affected in dominant and recessive myotonia
36. Transmembrane topology of a CLC chloride channel
37. Topology of the Shaker potassium channel probed with hydrophilic epitope insertions
38. Primary structure and functional expression of a developmentally regulated skeletal muscle chloride channel
39. Multimeric structure of ClC-1 chloride channel revealed by mutations in dominant myotonia congenita (Thomsen)
40. ClC channels: Leaving the dark ages on the verge of a new millennium
41. From tonus to tonicity: Physiology of CLC chloride channels
42. Studies on the membrane topology of the (Na,K)-ATPase