Oestrogen, progesterone and serotonin converge on GABAergic neurones in the monkey hypothalamus

Journal of Neuroendocrinology

Volumn 13, Issue 2, 2001, Pages 182-192

  Mirkes, S J ^a   Bethea, Cynthia L ^a,b  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

Glutamic acid decarboxylase; Luteinizing hormone; Ovarian steroids; Primate; Prolactin; Serotonin receptor

Indexed keywords

4 AMINOBUTYRIC ACID RECEPTOR; ENZYME; ESTROGEN; MESSENGER RNA; PLACEBO; PROGESTERONE; SEROTONIN; SEROTONIN 2C RECEPTOR;

4 AMINOBUTYRIC ACID RELEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARCUATE NUCLEUS; ARTICLE; CELL LABELING; CONTROLLED STUDY; DIAGONAL BAND OF BROCA; FEMALE; GLOBUS PALLIDUS; HORMONE ACTION; HYPOTHALAMUS; HYPOTHALAMUS NUCLEUS; HYPOTHALAMUS PERIVENTRICULAR NUCLEUS; HYPOTHALAMUS VENTROMEDIAL NUCLEUS; IN SITU HYBRIDIZATION; MEDIAL PREOPTIC AREA; MONKEY; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; STRIA TERMINALIS; SUPRACHIASMATIC NUCLEUS; TUBEROHYPOPHYSEAL TRACT;

ANIMALS; ESTROGENS; FEMALE; GAMMA-AMINOBUTYRIC ACID; GLUTAMATE DECARBOXYLASE; HYPOTHALAMUS; IN SITU HYBRIDIZATION; ISOENZYMES; MACACA NEMESTRINA; NEURONS; OSMOLAR CONCENTRATION; PROGESTERONE; RECEPTOR, SEROTONIN, 5-HT2C; RECEPTORS, SEROTONIN; RNA, MESSENGER; SEROTONIN;

EID: 0035176641     PISSN: 09538194     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2826.2001.00612.x     Document Type: Article

References (77)

1. Hyperprolactinemia induced by an estrogen-progesterone synergy: Quantitative and temporal effects of estrogen priming in monkeys
2. Regulation and localization of estrogen and progestin receptors in the pituitary of steroid treated monkeys
3. Steroid regulation of tyrosine hydroxylase mRNA in dopaminergic subpopulations of monkey hypothalamus
4. RU 486 blocks and fluoxetine augments progesterone-induced prolactin secretion in monkeys
5. Immunocytochemical colocalization of hypothalamic progestin receptors and tyrosine hydroxylase in steroid-treated monkeys
6. Reduced frequency of pulsatile luteinizing hormone secretion in the luteal phase of the rhesus monkey. Involvement of endogenous opiates
7. Pulsatile secretion of luteinizing hormone during the menstrual cycle of rhesus macaques
8. The roles of estradiol and progesterone in decreasing luteinizing hormone pulse frequency in the luteal phase of the menstrual cycle
9. Inhibition of estradiol-induced gonadotropin release in ovariectomized rhesus macaques by a gonadotropin-releasing hormone antagonist
10. Disruption of GnRH pulses by anti-GnRH serum and phentolamine obliterates plusatile LH but not FSH secretion in ovariectomized rabbits
11. Preovulatory gonadotropin-releasing hormone surge in ovarian-intact rhesus monkeys
12. Neuroendocrine signals in the regulation of gonadotropin-releasing hormone secretion
13. Chemical characterization of neuroendocrine targets for progesterone in the female rat brain and pituitary
14. Estrogen receptor and progesterone receptor-immunoreactive cells are not co-localized with gonadotropin-releasing hormone in the brain of the female mink (Mustel vison)
15. Progestin receptor-containing cells in guinea pig hypothalamus: Afferent connections, morphological characteristics, and neurotransmitter content
16. Estrogen responsive cells in the arcuate nucleus of the rat contain glutamic acid decarboxylase (GAD): An electron microscopic immunocytochemical study
17. Transmitter content and afferent connections of estrogen-sensitive progestin receptor-containing neurons in the primate hypothalamus
18. Estrogen induces ultrastructural changes in progesterone receptor-containing GABA neurons of the primate hypothalamus
19. Progesterone suppression of glutamic acid decarboxylase (GAD67) mRNA levels in the preoptic area: Correlation to the luteinizing hormone surge
20. Serotonin receptors: Subtypes, functional responses and therapeutic relevance
21. Multiple serotonin receptors: Too many, not enough, or just the right number?
22. Ovarian steroid effects on serotonin 1A, 2A and 2C receptor mRNA in macaque hypothalamus
23. 5HT1C receptor is a prominent serotonin receptor subtype in the central nervous system
24. Regional distribution of glutamic acid decarboxylase (GAD65 and GAD67) mRNA in the hypothalamus of male rhesus macaques before and after puberty
25. Ovarian steroid regulation of tryptophan hydroxylase mRNA expression in rhesus macaques
26. Regulation of serotonin re-uptake transporter mRNA expression by ovarian steroids in rhesus macaques
27. Ovarian steroid regulation of 5HT1A autoreceptor messenger ribonucleic acid expression in the dorsal raphe of rhesus macaques
28. The primate oviduct and endometrium
29. Immunocytochemical localization of progestin receptors in monkey hypothalamus: Effect of estrogen and progestin
30. Stereotaxic atlas of the brain of Macaca fuscata
31. Two genes encode distinct gluamate decarboxylases
32. The relationship between progestins and gonadotropins during the late luteal phase of the menstrual cycle in rhesus monkeys
33. Estrogens in fetal and maternal plasma of the rhesus monkey
34. Glutamic acid decarboxylase-containing axons synapse on LHRH neurons in the rat medial preoptic area
35. Role of classic and peptide neuromediators in the neuroendocrine regulation of luteinizing hormone and prolactin
36. Intrinsic tyrosine hydroxylase (TH) immunoreactive axons synapse with TH immunopositive neurons in the rat arcuate nucleus
37. The arcuate nucleus: A site for gamma-aminobutyric acid regulation of prolactin secretion
38. Involvement of catecholamines and glutamate in GABAergic mechanism regulatory to luteinizing hormone and prolactin secretion
39. GABAergic regulation of tuberoinfundibular dopaminergic neurons in the male rat
40. Effect of infusing gamma-aminobutyric acid receptor agonists and antagonists into the medial preoptic area and ventromedial hypothalamus on prolactin secretion in male sheep
41. In vivo interaction of baclofen, TRH and serotonin in PRL and TSH secretion in the developing and adult male and female rats
42. A GABA B-receptor mechanism is involved in the prolactin release in both male and female rats
43. [Prolactin after baclofen in healthy subjects and prolactinoma patients]
44. Effects of GABA receptor agonists on [3H]dopamine release from median eminence and pituitary neurointermediate lobe
45. Regulation of luteinizing hormone-releasing hormone and luteinizing hormone secretion by hypothalamic amino acids
46. Gamma amino-butyric acid and the control of GnRH secretion in sheep
47. Effects of dialyzing gamma-aminobutyric acid receptor antagonists into the medial preoptic and arcuate ventromedial region on luteininzing hormone release in male sheep
48. Control of luteininzing hormone-releasing hormone pulse generation in nonhuman primates
49. A role of γ-amino butyric acid (GABA) and glutamate in control of puberty in female rhesus monkeys: Effect of an antisense oligodeoxynucleotide for GAD67 messenger ribonucleic acid and MK801 release
50. Effects of pulsatile infusion of the GABA (A) receptor blocker bicuculline on the onset of puberty in female rhesus monkeys
51. Sex difference in serum luteinizing hormone postgonadectomy in the rat: Role of gamma-aminobutyric acid-ergic inhibition
52. Glutamic acid decarboxylase cDNA: Nucleotide sequence encoding an enzymatically active fusion protein
53. The hydrophilic isoform of glutamate decarboxylasse, GAD67, is targeted to membranes and nerve terminals independent of dimerization with the hydrophobic membrane-anchored isoform, GAD65
54. Phophorylation of serine residues 3, 6, 10, and 13 distinguishes membrane anchored from soluble glutamic acid decarboxylase 65 and is restricted to glutamic acid decarboxylase 65alpha
55. The level of GAD67 protein is highly sensitive to small increases in intraneuronal gamma-aminobutyric acid levels
56. Decrease in glutamic acid decarboxylase level in the hypothalamus of spontaneously hypertensive rats
57. An increase in glutamate release follows a decrease in gamma aminobutyric acid and the pubertal increase in luteinizing hormone releasing hormone release in female rhesus monkeys
58. Two forms of the gamma-aminobutyric acid synthetic enzyme glutamate decarboxylase have distinct intraneuronal distributions and cofactor interactions
59. Mice lacking the 65 KDa isoform of glutamic acid decarboxylase (GAD65) maintain normal levels of GAD67 and GABA in their brains but are susceptible to seizures
60. Structure and function of the brain serotonin system
61. Effect of selective serotonin receptor agonists on prolactin secretion in male rats
62. Participation of serotonin-containing neurons in the suckling-induced rise in plasma prolactin levels in lactating rats
63. International union of pharmacology classification of receptors for 5-hydroxytryptamine (serotonin)
64. Progestin receptors in β-endorphin and substance P neurons of steroid treated monkeys
65. Immunocytochemical colocalization of progestin receptors and β-endorphin or enkephalin in the hypothalamus of female guinea pigs
66. β-endorphin, but not oxytocin, substance P or vasoactive-intestinal polypeptide contributes, to progesterone-induced prolactin secretion in monkeys
67. Endogenous opiates regulate the nocturnal reduction in luteinizing hormone pulse frequency during the luteal phase of the macaque menstrual cycle
68. Role of endogenous opioids in reducing the frequency of pulsatile luteinizing hormone secretion induced by progesterone in normal women
69. Effect of sex steroids on β-endorphin in hypophyseal portal blood
70. β-endorphin innervation of dopamine neurons in the rat hypothalamus: A light and electron microscopic double immunostaining study
71. Immunohistochemical evidence for synaptic connections between pro-opiomelanocortin-immunoreactive axons and LH-RH neurons in the preoptic area of the rat
72. Immunocytochemical evidence for oestrogen receptors within GABA neurones located in the perinuclear zone of the supraoptic nucleus and GABA A receptor beta 2/beta 3 subunits on supraoptic oxytocin neurones
73. Enhanced serotonergic transmission stimulated oxytocin secretion in conscious male rats
74. Role of the hypothalamic paraventricular nucleus in 5-HT 1A, 5-HT 2A and 5-HT 2C receptor-mediated oxytocin, prolactin and ACTH/corticosterone responses
75. Neurons in the hypothalamic paraventricular nucleus mediate the serotonin stimulus of prolactin secretion via 5HT1C/2 receptors
76. Neuroendocrine pharmacology of serotonergic (5HT) neurons
77. Ovarian steroids and serotonin neural function