Loss of heterozygosity at the mannose 6-phosphate insulin-like growth factor 2 receptor (M6P/IGF2R) locus predisposes patients to radiation-induced lung injury

International Journal of Radiation Oncology Biology Physics

Volumn 49, Issue 1, 2001, Pages 35-41

  Kong, Feng Ming ^a   Anscher, Mitchell S ^a,c   Sporn, Thomas A ^a   Washington, Mary K ^a   Clough, Robert ^a   Barcellos Hoff, Mary H ^b   Jirtle, Randy L ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c DUKE CANCER INSTITUTE   (United States)

Author keywords

Complications; Mannose 6 phosphate insulin like growth factor type 2 receptor; Radiation pneumonitis

Indexed keywords

ACID; ALCOHOL; CYTOKINE; SOMATOMEDIN B RECEPTOR; TRANSFORMING GROWTH FACTOR BETA1;

ADULT; AGED; ARTICLE; BLOOD LEVEL; CANCER RADIOTHERAPY; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION FUNCTION; DISEASE PREDISPOSITION; ENZYME LINKED IMMUNOSORBENT ASSAY; EXTRACELLULAR MATRIX; EXTRACTION; FEMALE; GENE LOCUS; GENETIC POLYMORPHISM; HETEROZYGOSITY LOSS; HOMOZYGOSITY; HUMAN; HUMAN TISSUE; IMMUNOFLUORESCENCE MICROSCOPY; IMMUNOHISTOCHEMISTRY; LUNG CARCINOMA; LUNG INJURY; MALE; MUTATION; PATHOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RADIATION PNEUMONIA; RADIOGRAPHY; SCORING SYSTEM; STAINING; STROMA; THORAX; UNTRANSLATED REGION;

NON-PROGRAMMATIC;

ADENOCARCINOMA; ADULT; AGED; AGED, 80 AND OVER; CARCINOMA, LARGE CELL; CARCINOMA, SQUAMOUS CELL; FEMALE; GENETIC MARKERS; GENETIC PREDISPOSITION TO DISEASE; HUMANS; LOSS OF HETEROZYGOSITY; LUNG NEOPLASMS; MALE; MIDDLE AGED; RADIATION PNEUMONITIS; RECEPTOR, IGF TYPE 2;

EID: 0035174298     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0360-3016(00)01377-8     Document Type: Article

References (57)

1. Transforming growth factor-β; Multiple actions and potential clinical applications
2. TGFβ regulation of extracellular matrix
3. Transforming growth factor-β1 expression in irradiated liver
4. Alterations in pulmonary mRNA encoding procollagens, fibronectin, and transforming growth factor beta precede bleomycin-induced pulmonary fibrosis
5. Early increases in pulmonary mRNA encoding procollagens and transforming growth factor beta in mice sensitive to cyclophosphamide-induced pulmonary fibrosis
6. Effect of antibody to transforming growth factor β on bleomycin induced accumulation of lung collagen in mice
7. The transforming growth factor-β family
8. Cellular activation of latent transforming growth factor β requires binding to the cation-independent mannose 6-phosphate/insulin-like growth factor type II receptor
9. Resistance to inhibition of cell growth by transforming growth factor-beta and its role in oncogenesis
10. Elevated plasma TGFβ1 levels in breast cancer patients decrease following removal of the tumor
11. Elevated levels of plasma transforming growth factor-β in patients with hepatocellular carcinoma
12. Plasma transforming growth factor-b1 in patients with hepatocellular carcinoma; Comparison with chronic liver diseases
13. Elevated plasma levels of TGFβ1 in patients with invasive prostate cancer
14. Plasma transforming growth factor β1 reflects disease status in patients with lung cancer after radiotherapy; A possible tumor marker
15. Plasma transforming growth factor β1 as a predictor of radiation pneumonitis
16. Transforming growth factor β as a predictor of liver and lung fibrosis after autologous bone marrow transplantation for advanced breast cancer
17. Plasma TGF-β levels during radiotherapy with or without carboplatin predicts pneumonitis in stage III non-small-cell lung cancer
18. 4-exposed rat fat-storing cells and facilitates activation of latent transforming growth factor-β in cocultures with sinusoidal endothelial cells
19. Insulin-like growth factor II receptor as a multifunctional binding protein
20. Structure and function of the mannose 6-phosphate/insulin-like growth factor II receptors
21. Genomic imprinting and cancer
22. Mannose 6-phosphate/insulin-like growth factor II receptor mediates the growth-inhibitory effects of retinoids
23. Decreased insulin-like growth factor-II/mannose 6-phosphate receptor expression enhances tumorigenicity in JEG-3 cells
24. Expression of the wild-type insulin-like growth factor II receptor gene suppresses growth and causes death in colorectal carcinoma cells
25. Isolation and characterization of mutant cell lines defective in transforming growth factor b signaling
26. Cytogenetic analysis of short-term cultured squamous cell carcinomas of the lung
27. Homozygous deletion on chromosome 9p and loss of heterozygosity on 9q, 6p, and 6q in primary human small cell lung cancer
28. Cytogenetic analysis of 63 non-small-cell lung carcinoma; Recurrent chromosome alterations amid frequent and widespread genomic upheaval
29. Common toxicity criteria; Version 2.0. An improved reference for grading the acute effects of cancer treatment: Impact on radiotherapy
30. Frequent loss of heterozygosity on 6q at the mannose-6-phosphate/insulin-like growth factor II receptor locus in human hepatocellular tumors
31. M6P/IGF2 receptor; A candidate breast tumor suppressor gene
32. Regulation of mannose 6-phosphate/insulin-like growth factor-II receptors and transforming growth factor beta during liver tumor promotion with phenobarbitol
33. Utility of microwave-citrate antigen retrieval in diagnostic immunohistochemistry
34. Transforming growth factor beta activation in irradiated murine mammary gland
35. Identification and activation of latent transforming growth factor β
36. The utility of SPECT lung perfusion scans in minimizing and assessing the physiologic consequences of thoracic irradiation
37. Radiation pneumonitis as a function of mean lung dose; An analysis of pooled data of 540 patients
38. Improving the polymorphism content of the 3′ UTR of the human IGF2R gene
39. Tolerance of normal tissue to therapeutic irradiation
40. A perpetual cascade of cytokines post irradiation leads to pulmonary fibrosis
41. TGF-β1 and radiation fibrosis; A master switch and a specific target?
42. Early alteration in extracellular matrix and transforming growth factor β gene expression in mouse lung indicative of late radiation fibrosis
43. TGF-β1 production in radiation nephropathy; Role of angiotensin II
44. Expression of fibrogenic cytokines in rat small intestine after fractionated irradiation
45. Blockade of type β transforming growth factor signaling prevents liver fibrosis and dysfunction in the rat
46. Transforming growth factors beta-1 and alpha in chronic liver disease-effects of interferon alpha therapy
47. Suppression of experimental glomerulonephritis by antiserum against transforming growth factor beta 1
48. Tumor marker protocols; Plasma transforming growth factor beta, a plasma tumor marker
49. Normal tissue injury after cancer therapy is a local manifestation of a systemic condition
50. Changes in plasma TGF-β levels during pulmonary radiotherapy as a predictor of the risk of developing radiation pneumonitis
51. Changes in plasma transforming growth factor beta during radiotherapy and the risk of symptomatic radiation-induced pneumonitis
52. TGFβ, radiation-induced pulmonary injury and lung cancer
53. Calculation of complication probability factors for non-uniform normal tissue irradiation; The effective volume method
54. Optimization of radiation therapy III. A method of assessing complication probabilities from dose-volume histograms
55. Physical and biological predictors of changes in whole-lung function following thoracic irradiation