Characterization and localization of cytochrome P450 mediated metabolism of MPTP to nor-MPTP in mouse brain: Relevance to Parkinson's disease

Neurotoxicity Research

Volumn 3, Issue 4, 2001, Pages 369-380

  Upadhya, Sudarshan C ^a,c   Boyd, Michael R ^b   Ravindranath, Vijayalakshmi ^a,c  

^a NATIONAL INSTITUTE OF MENTAL HEALTH AND NEUROSCIENCES   (India)

^b NATIONAL CANCER INSTITUTE   (United States)

^c INTERNATIONAL CENTRE FOR GENETIC ENGINEERING AND BIOTECHNOLOGY ICGEB   (India)

Author keywords

Brain; Cytochrome P450; Cytochrome P4502D; Mono oxygenases; MPTP; Parkinson's disease

Indexed keywords

1 METHYL 4 PHENYLPYRIDINIUM; 1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; AMINE OXIDASE (FLAVIN CONTAINING); CYTOCHROME P450; CYTOCHROME P450 2D; CYTOCHROME P450 2D6; ISOENZYME; MESSENGER RNA; NEUROTOXIN; QUINIDINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOTRANSFORMATION; BRAIN CORTEX; BRAIN MICROSOME; CELL LOSS; CELL SUBPOPULATION; CEREBELLUM; CHEMICAL STRUCTURE; CONTROLLED STUDY; DETOXIFICATION; DOPAMINERGIC ACTIVITY; ENZYME ACTIVITY; ENZYME LOCALIZATION; FLUORESCENCE IN SITU HYBRIDIZATION; GENETIC POLYMORPHISM; GRANULE CELL; HIPPOCAMPUS; LIVER; MALE; MESENCEPHALON; MOUSE; NERVE CELL; NONHUMAN; NORTHERN BLOTTING; PARKINSON DISEASE; PATHOGENESIS; PRIMATE; PRIORITY JOURNAL; PURKINJE CELL; RETICULUM CELL; SYMPTOM; THALAMUS; TOXICOKINETICS;

EID: 0035170851     PISSN: 10298428     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF03033198     Document Type: Article

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