Paralyzation and sedation of the ventilated trauma patient

Respiratory Care Clinics of North America

Volumn 7, Issue 1, 2001, Pages 97-126

  Primak, Lara K ^a   Lowrie, Lia ^a  

^a CASE WESTERN RESERVE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATRACURIUM; BARBITURIC ACID DERIVATIVE; BENZODIAZEPINE DERIVATIVE; CISATRACURIUM; DIAZEPAM; DOXACURIUM; FENTANYL; FLUMAZENIL; KETAMINE; LORAZEPAM; MIDAZOLAM; MIVACURIUM; MORPHINE; NEUROMUSCULAR BLOCKING AGENT; PANCURONIUM; PETHIDINE; PROPOFOL; SEDATIVE AGENT; SUXAMETHONIUM; THIOPENTAL; VECURONIUM;

ANALGESIA; ARTICLE; ARTIFICIAL VENTILATION; CHILD; CHILDHOOD INJURY; COMPLICATION; CONTROLLED STUDY; DRUG EFFECT; DRUG EXCRETION; DRUG HALF LIFE; DRUG METABOLISM; HUMAN; HYPERKALEMIA; HYPERTHERMIA; HYPOTENSION; INTENSIVE CARE UNIT; MUSCLE WEAKNESS; NEUROMUSCULAR BLOCKING; PARALYSIS; PARESIS; PHARMACODYNAMICS; RESPIRATION DEPRESSION; RHABDOMYOLYSIS; SEDATION; SEIZURE; TECHNOLOGY; VENTILATOR; WITHDRAWAL SYNDROME;

EID: 0035169939     PISSN: 10785337     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1078-5337(05)70025-3     Document Type: Article

References (171)

1. Sleep helps healing
2. Comparison of propofol and midazolam for sedation in critically ill patients
3. Comparison of thiopentone and propofol at two rates of administration in patients with severe head injury
4. In vivo correlates of benzodiazepine cerebrospinal fluid uptake pharmacodynamic action and peripheral distribution
5. Methods for monitoring the level of sedation
6. Pharmacokinetics of propofol during and after long term continuous infusion for maintenance of sedation in ICU patients
7. Propofol infusion in children
8. Optimal intravenous dosing strategies for sedatives and analgesics in the intensive care unit
9. Depth of sedation vs. propofol concentration in mechanically ventilated ICU patients
10. Prolonged sedation with propofol in ICU patients: Recovery and blood concentration changes during periodic interruptions in infusion
11. Postoperative infections traced to contamination of an intravenous anesthetic propofol
12. Propofol-related seizures
13. Reversible neurological abnormalities associated with prolonged intravenous midazolam and fentanyl administration
14. Patterns of postoperative analgesia use with adults and children following cardiac surgery
15. Hemodynamic and gas exchange effects of pancuronium bromide in sedated patients with respiratory failure
16. Propofol infusion and green urine
17. Sedation of children requiring artificial ventilation using an infusion of midazolam
18. Intensive management of severe head injury
19. Propofol and epilepsy: Time to clarify!
20. Unplanned extubations in the adult intensive care unit: A prospective multicenter study
21. Reversal of midazolam sedation with flumazenil
22. Clinical electroencephalographic and pharmacokinetic studies of a water-soluble benzodiazepine midazolam maleate
23. Energy expenditure and withdrawal of sedation in severe head-injured patients
24. Use of nondepolarizing neuromuscular blocking agents in mechanically ventilated patients
25. The use of sedative agents in critically ill patients
26. The pharmacodynamics and pharmacokinetics of the metabolite 3-desacetylvecuronium (ORG 7268) and its parent compound vecuronium in human volunteers
27. Pharmacologic agents
28. Vecuronium and prolonged neuromuscular blockade in postpartum patients
29. Plasma urine and cerebrospinal fluid catecholamine concentrations during and after ketamine sedation
30. Unplanned extubation: Risk factors of development and predictive criteria for reintubation
31. Sedatives and antagonists in the management of severely head-injured patients
32. The effects of midazolam reversal by RO 15-1788 on cerebral perfusion pressure in patients with severe head injury
33. Haemodynamic changes during anaesthesia induced and maintained with propofol
34. Hemodynamic effects of infusions of the emulsion formulation of propofol during nitrous oxide anesthesia in humans
35. Improved oxygenation after muscle relaxation in adult respiratory distress syndrome
36. The action of the general anesthetic propofol on GABA-A receptors
37. Propofol as a sole agent for prolonged infusion in intensive care
38. Comparison of intubating conditions after administration of rocuronium and suxamethonium
39. Sedation for the pediatric patient
40. Effects of diazepam on cerebral blood flow and oxygen uptake after head injury
41. Neuromuscular blockade: Should patients be relaxed in the ICU
42. Lactic academia and bradyarrhythmia in a child sedated with propofol
43. Relationship between plasma concentration and effect of midazolam after oral and intravenous administration
44. Sleep in the pediatric ICU: An empirical investigation
45. Management of raised intracranial pressure after severe head injury
46. A study to compare the use of propofol and midazolam for the sedation of patients with acute respiratory failure
47. Cerebrovascular hypoxic and autoregulatory response during reduced brain metabolism
48. Comparison of propofol with methohexital for outpatient anesthesia
49. Twenty-five years of ketamine
50. Studies of drugs given before anesthesia XXVI: Lorazepam
51. Amnesic action of midazolam
52. Suxamethonium
53. Neuromuscular blocking agents and sedative drugs: Clinical uses and toxic effects in the critical care unit
54. The effect on serum lipid concentrations of a prolonged infusion of propofol: Hypertriglyceridemia associated with propofol administration
55. Asystole and anesthesia induction with a fentanyl propofol and succinylcholine sequence
56. Continuous propofol infusion for sedation in delirium tremens
57. Propofol infusion for sedation of patients with head injury in intensive care: A preliminary report
58. Cerebral effects of high-dose midazolam and subsequent reversal with Ro15-1788 in dogs
59. Effects of midazolam on cerebral blood flow in human volunteers
60. Relative amnesiac actions of diazepam flunitrazepam and lorazepam in man
61. Disposition of propofol administered as constant rate intravenous infusions in humans
62. Effect of prolonged sedation with propofol on serum triglyceride and cholesterol concentrations
63. Sedation: Intravenous benzodiazepines in critical care medicine
64. Clinical importance of the interaction of diazepam and cimetidine
65. Clinical pharmacokinetics of the newer benzodiazepines
66. Kinetic and dynamic study of intravenous lorazepam: Comparison with intravenous diazepam
67. Acute myopathy during treatment of status asthmaticus with corticosteroids and steroidal muscle relaxants
68. Neuromuscular blocking drugs in infants and children
69. Propofol infusion for sedation in the intensive care unit: A preliminary report
70. Concentrations of atracurium and laudanosine in cerebrospinal fluid and plasma in three intensive care patients
71. Use of sedating drugs and neuromuscular blocking agents in patients requiring mechanical ventilation for respiratory failure
72. Propofol and alfentanil for sedation in intensive therapy
73. Propofol for long-term sedation in the intensive care unit: A comparison with papaveretum and midazolam
74. Propofol-infusion syndrome in children
75. Effect of propofol on elevated intracranial pressure: Preliminary results
76. Early routine paralysis for intracranial pressure control in severe head injury: Is it necessary?
77. Continuous infusions of propofol
78. Differential effects of propofol and nitrous oxide on posterior tibial nerve somatosensory evoked potentials during alfentanil anesthesia
79. Propofol in the treatment of moderate and severe head injury: A randomized prospective double-blinded pilot trial
80. Cardiovascular effects of pancuronium in man
81. Drug interactions and clinical pharmacokinetics of flumazenil
82. Tolerance to alprazolam after intravenous bolus and continuous infusion: Psychomotor and EEG effects
83. Disuse atrophy in a ventilated patient with status asthmaticus receiving neuromuscular blockade
84. Propofol: A review of its pharmacodynamic and pharmacokinetic properties and use as an intravenous anesthetic
85. Wheal and flare responses to muscle relaxants in humans
86. Dose response to intramuscular succinylcholine in children
87. Infusion of midazolam in paediatric patients after cardiac surgery
88. Barbiturates neuroleptics and propofol for sedation
89. Severe myopathy after status asthmaticus
90. Propofol infusion for control of status epilepticus
91. Pharmacokinetics of midazolam administered by continuous infusion to intensive care patients
92. Pharmacokinetic-pharmacodynamic modeling of the central nervous system effects of midazolam and its main metabolite alpha hydroxymidazolam in healthy volunteers
93. A clinical prediction rule for delirium after elective noncardiac surgery
94. Metabolic biochemical and haemodynamic effects of infusion of propofol for long-term sedation of children undergoing intensive care
95. Sedation for the mechanically ventilated patient
96. Cerebral hemodynamics in patients with acute severe head trauma
97. Prolonged weakness after infusion of atracurium in two intensive care unit patients
98. Sedation for the critically ill neurologic patient
99. Paralyzation and sedation of the ventilated patient
100. Opioids and benzodiazepines
101. The use of neuromuscular blocking drugs in the intensive care unit: A U.S. perspective
102. Propofol infusion for sedation in intensive care
103. Propofol infusion for sedation of children
104. Sedation with intravenous midazolam in the pediatric intensive care unit
105. Neuromuscular complications in patients given Pavulon (pancuronium bromide) during artificial ventilation
106. Propofol and thiopental depression of myocardial contractility: A comparative study of mechanical and electrophysiologic effects in isolated guinea pig ventricular muscle
107. Metabolic acidosis and fatal myocardial failure after propofol infusion in children: Five case reports
108. Pharmacokinetics of atracurium and laudanosine in patients with hepatic cirrhosis
109. Disposition of infusions of atracurium and its metabolite laudanosine in patients in renal and respiratory failure in an ITU
110. Double-blind study of the reversal of midazolam-induced sedation in the intensive care unit with flumazenil (Ro 15-788): Effect on weaning from mechanical ventilation
111. High-dose barbiturate therapy in Neuro-surgery and intensive care
112. Effects of propofol on cerebral hemodynamics and metabolism in patients with brain trauma
113. Fatal side-effects of continuous propofol infusion in children may be related to malignant hyperthermia
114. Continuous intravenous infusions of lorazepam versus midazolam for sedation during mechanical ventilatory support: A prospective randomized study
115. Recognition and management of anxiety in the intensive care unit
116. Sedative and neuromuscular blocking drug use in critically ill patients with head injuries
117. Complications associated with sedative and neuromuscular blocking drugs in critically ill patients
118. Effects of graded infusion rates of propofol on regional and global left ventricular function in the dog
119. Propofol bashing: The time to stop is now!
120. A pharmacokinetically based propofol dosing strategy for sedation of the critically ill mechanically ventilated pediatric patient
121. Midazolam: Pharmacology and uses
122. High dose barbiturate therapy in humans: A clinical review of 60 patients
123. Food and Drug Administration's Center for Drug Evaluation and Research: Report of Anesthetic and Life Support Drugs Advisory Committee
124. Comparison of propofol and midazolam for sedation in intensive care unit patients
125. Pediatric analgesia and sedation
126. Propofol versus midazolam: Safety and efficacy for sedating the severe trauma patient
127. Status of pediatric pain control: A comparison of hospital analgesic use in children and adults
128. Propofol: A new intravenous anesthetic
129. Persistent paralysis in critically ill patients after long-term administration of vecuronium
130. Pharmacokinetics of propofol infusions in patients with cirrhosis
131. Pharmacokinetics variability of midazolam infusions in the critically ill patient
132. Practice parameters for sustained neuromuscular blockade in the adult critically ill patient: An executive summary
133. The use of muscle relaxants in the intensive care unit
134. 14C-propofol to male volunteers
135. Prolonged neuromuscular blockade with vecuronium in patients treated with magnesium sulfate
136. Neuromuscular blocking agents in the intensive care unit: A two-edged sword
137. Vecuronium infusions in patients with renal failure in an ITU
138. Propofol: An update on its clinical use
139. The use of midazolam versus propofol for short term sedation following coronary bypass grafting
140. Invasive procedures in children receiving intensive care
141. Effects of Disoprivan on cerebral blood flow oxygen consumption and cerebral vascular reactivity
142. Propofol sedation in severe head injury fails to control high ICP but reduces brain metabolism
143. Pharmacology and Physiology in Anesthetic Practice
144. Fatal metabolic acidosis in a pediatric patient receiving an infusion of propofol in the intensive care unit: Is there a relationship?
145. Propofol toxicity in critically ill pediatric patients: Show us the proof
146. Continuous infusion of lorazepam versus midazolam in patients in the intensive care unit: Sedation with lorazepam is easier to manage and is more cost-effective
147. Intravenous anaesthetic agents: Pharmacokinetic-pharmacodynamic relationships
148. Effect of routine administration of analgesia on energy expenditure in critically ill patients
149. The effects of ketamine on cerebral circulation and metabolism in man
150. The use of neuromuscular blocking agents in children
151. Pancuronium infusion for neuromuscular blockade in children in the pediatric intensive care unit
152. Ketamine by continuous infusion for sedation in the pediatric intensive care unit
153. Pain management and sedation in the pediatric intensive care unit
154. Neurological sequellae in children after prolonged propofol infusion
155. Research (Anaesthetic and Life Support Drugs Advisory Committee): ICI's Diprivan (propofol) anesthetic has no direct link to pediatric deaths in ICU's
156. Propofol anaesthesia does not inhibit stimulation of cortisol synthesis
157. Extrahepatic metabolism of propofol in man during the anhepatic phase of orthotopic liver transplantation
158. Propofol in sedative doses is an amnestic agent
159. Atracurium infusion in the intensive care unit
160. Failure of prophylactic barbiturate coma in the treatment of severe head injury
161. Prolonged paralysis in intensive care unit patients after the use of neuromuscular blocking agents: A review of the literature
162. Cardiovascular effects of anesthetic induction with ketamine
163. Pharmacodynamics of vecuronium and atracurium in the obese surgical patient
164. Pentobarbital pharmacokinetics in patients with severe head injury
165. Atracurium in the intensive care unit
166. A randomized study of drugs for preventing increases in intracranial pressure during endotracheal suctioning
167. Ketamine: Its pharmacology and therapeutic uses
168. Withdrawal reaction from long-term low-dosage administration of diazepam: A double-blind placebo-controlled case study
169. Clinical experience and plasma laudanosine concentrations during the infusion of atracurium in the intensive therapy unit
170. The effect of ketamine on intraocular pressure in children
171. Comparison of the effects of intravenously administered midazolam triazolam and their hydroxymetabolites