Lactic acidemia and bradyarrhythmia in a child sedated with propofol

Critical Care Medicine

Volumn 26, Issue 12, 1998, Pages 2087-2092

  Cray, Steven H ^a   Robinson, Brian H ^a   Cox, Peter N ^a  

^a HOSPITAL FOR SICK CHILDREN   (Canada)

Author keywords

Bradycardia; Hemofiltration; Lactic acidosis; Pediatric intensive care unit; Propofol; Sedation

Indexed keywords

CYTOCHROME C OXIDASE; PROPOFOL;

ARTICLE; ARTIFICIAL VENTILATION; BRADYCARDIA; CASE REPORT; ENDOTRACHEAL INTUBATION; ENZYME ACTIVITY; ESOPHAGUS FOREIGN BODY; HEMOFILTRATION; HUMAN; HYPERLIPIDEMIA; INFANT; INTRAVENOUS DRUG ADMINISTRATION; LACTIC ACIDEMIA; LIVER NECROSIS; MALE; MUSCLE NECROSIS; PRIORITY JOURNAL; SEDATION; UPPER RESPIRATORY TRACT OBSTRUCTION;

ACIDOSIS, LACTIC; BRADYCARDIA; CONSCIOUS SEDATION; FATTY LIVER; HUMANS; HYPERLIPIDEMIAS; HYPNOTICS AND SEDATIVES; INFANT; INFUSIONS, INTRAVENOUS; MALE; MUSCULAR DISEASES; NECROSIS; OLIGURIA; PROPOFOL; RESPIRATION, ARTIFICIAL;

EID: 0032445325     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/00003246-199812000-00046     Document Type: Article

References (31)

1. Reves JG, Glass PS, Lubarsky DA: Nonbarbiturate intravenous anesthetics. In: Anesthesia. 4th Edition. Miller RD (Ed). New York, Churchill Livingstone, 1994, pp 269-274
2. Bennett SN, McNeil MM, Bland LA, et al: Postoperative infections traced to contamination of an intravenous anesthetic, propofol. N Engl J Med 1995; 333:147-154
3. Grounds RM, Lalor JM, Lumley J, et al: Propofol infusion for sedation in the intensive care unit: Preliminary report. BMJ 1987; 294:397-400
4. Aitkenhead AR, Willats SM, Park GR, et al: Comparison of propofol and midazolam for sedation in critically ill patients. Lancet 1989; ii:704-709
5. Diprivan (propofol) product monograph. Zeneca Pharma Inc., Mississauga, Canada
6. Edwards KG, Arnold BD: Propofol infusion in children. BMJ 1992; 305:952
7. Reed MD, Yamashita TS, Marx CM, et al: A pharmacokinetically based propofol dosing strategy for sedation of the critically ill, mechanically ventilated pediatric patient. Crit Care Med 1996; 24:1473-1481
8. Hughes MA, Glass PS, Jacobs JR: Context-sensitive half-time in multi-compartment pharmacokinetic models for intravenous anesthetic drugs. Anesthesiology 1992; 76:334-341
9. Smith I, White PF, Nathanson M, et al: Propofol: An update on its clinical use. Anesthesiology 1994; 81:1005-1043
10. Parke TJ, Stevens JE, Rice AS, et al: Metabolic acidosis and fatal myocardial failure after propofol infusion in children: Five case reports. BMJ 1992; 305:613-616
11. Barclay K, Williams AJ, Major E: Propofol infusion in children. BMJ 1992; 305:953
12. Bodd E, Endresen L: Use of propofol (Diprivan) for children. Tidsskr Nor Laegeforen 1992; 112:1636-1637
13. Bray RJ: Fatal myocardial failure associated with a propofol infusion in a child. Anaesthesia 1995; 50:94
14. Plötz FB, Waalkens HJ, Verkade HJ, et al: Fatal side-effects of continuous propofol infusion in children may be related to malignant hyperthermia. Anaesth Intensive Care 1996 24: 724-731
15. Strickland RA, Murray MJ: Fatal metabolic acidosis in a pediatric patient receiving an infusion of propofol in the intensive care unit: Is there a relationship? Crit Care Med 1995; 23:405-109
16. Cook S: Propofol infusion in children. BMJ 1992; 305:952
17. Macrae D, James I: Propofol infusion in children. BMJ 1992; 305:953
18. Reed MD, Blumer JL: Propofol bashing: The time to stop is now! Crit Care Med 1996; 24:175
19. Stacpoole PW, Harman EM, Curry SH, et al: Treatment of lactic acidosis with dichloroacetate. N Engl J Med 1983; 309:390-396
20. Burlina AB, Milanesi O, Biban P, et al: Beneficial effect of sodium dichloroacetate in muscle cytochrome C oxidase deficiency. Eur J Pediatr 1993; 152:537
21. Leisure GS, O'Flaherty J, Green L, et al: Propofol and postoperative pancreatitis. Anesthesiology 1996; 84: 224-227
22. Eddleston JM, Shelly MP: The effect on serum lipid concentrations of a prolonged infusion of propofol - hypertriglyceridaemia associated with propofol administration. Intensive Care Med 1991; 17:424-426
23. Barrientos-Vega R, Sánchez-Soria MM, Morales-Garcia C, et al: Prolonged sedation of critically ill patients with midazolam or propofol: Impact on weaning and costs. Crit Care Med 1997; 25:33-40
24. Carrasco G, Molina R, Costa J, et al: Propofol vs. midazolam in short-, medium-, and long-term sedation of critically ill patients. Chest 1993; 103: 557-564
25. Eddleston JM, Pollard BJ, Blades JF, et al: The use of propofol for sedation of critically ill patients undergoing haemodiafiltration. Intensive Care Med 1995; 21:342-347
26. Levraut J, Ciebiera J-P, Jambou P, et al: Effect of continuous venovenous hemofiltration with dialysis on lactate clearance in critically ill patients. Crit Care Med 1997; 25:58-62
27. Branca D, Roberti MS, Vincenti E, et al: Uncoupling effect of the general anesthetic 2,6-diisopropylphenol in isolated rat liver mitochondria. Arch Biochem Biophys 1991; 290:517-521
28. Branca D, Vincenti E, Scutari G: Influence of the anesthetic 2,6-diisopropylphenol (propofol) on isolated rat heart mitochondria. Comp Biochem Physiol Pharmacol Toxicol Endocrinol 1995; 110:41-45
29. Robinson BH: Lacticacidemia. Biochim Biophys Acta 1993; 1182:231-244
30. Tyni T, Majander A, Kalimo H, et al: Pathology of skeletal muscle and impaired respiratory chain function in long-chain 3-hydroxyacyl-CoA dehydro-genase deficiency with the G1528C mutation. Neuromuscul Disord 1996; 6:327-337
31. Hatch DJ: Propofol in paediatric intensive care. Br J Anaesth 1997; 79: 274-275