Donor-recipient polymorphism of the proteinase 3 gene: A potential target for T-cell alloresponses to myeloid leukemia

Journal of Immunotherapy

Volumn 22, Issue 1, 1999, Pages 1-6

  Clave, Emmanuel ^a   Molldrem, Jeffrey ^a   Hensel, Nancy ^a   Raptis, Anastasios ^a   Barrett, A John ^a  

^a NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

Author keywords

Bone marrow transplantation; Graft versus leukemia; Polymorphism; Proteinase 3

Indexed keywords

HLA A2 ANTIGEN; ISOLEUCINE; MYELOBLASTIN; VALINE;

ACUTE GRANULOCYTIC LEUKEMIA; ADOPTIVE IMMUNOTHERAPY; ALLELE; ALLOGENIC BONE MARROW TRANSPLANTATION; ARTICLE; CANCER RECURRENCE; CHRONIC MYELOID LEUKEMIA; CLINICAL ARTICLE; CONTROLLED STUDY; DONOR; FEMALE; GENE OVEREXPRESSION; GENETIC POLYMORPHISM; GRAFT VERSUS LEUKEMIA EFFECT; HUMAN; HUMAN CELL; MALE; MYELODYSPLASTIC SYNDROME; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SINGLE STRAND CONFORMATION POLYMORPHISM; T LYMPHOCYTE;

ALLELES; BONE MARROW TRANSPLANTATION; EXONS; FEMALE; FLOW CYTOMETRY; GENE FREQUENCY; GENOTYPE; GRAFT VS TUMOR EFFECT; HISTOCOMPATIBILITY TESTING; HLA-A ANTIGENS; HUMANS; LEUKEMIA, MYELOID; MALE; MYELOBLASTIN; PEPTIDE FRAGMENTS; POLYMORPHISM, GENETIC; POLYMORPHISM, SINGLE-STRANDED CONFORMATIONAL; PROTEIN BINDING; RECURRENCE; SERINE ENDOPEPTIDASES; T-LYMPHOCYTES; TISSUE DONORS;

EID: 0032948256     PISSN: 10538550     EISSN: None     Source Type: Journal    
DOI: 10.1097/00002371-199901000-00001     Document Type: Article

References (18)

1. Barrett J, Malkovska V. The graft-versus-leukemia effect. Curr Opin Oncol 1996;8:89-95.
2. Sosman JA, Oettel KR, Smith SD, Hank JA, Fisch P, Sondel PM. Specific recognition of human leukemic cells by allogeneic T cells: II. Evidence for HLA-D restricted determinants on leukemic cells that are crossreactive with determinants present on unrelated non-leukemic cells. Blood 1990;75:2005-16.
3. Cheever MA, Chen W, Disis ML, Takahashi M, Peace DJ. T-cell immunity to oncogenic proteins including mutated ras and chimeric bcr-abl. Ann NY Acad Sci 1993;690:101-12.
4. Barrett J, Guimaraes A, Cullis J, Goldman JM. Immunological characterization of the tumor-specific bcr/abl junction of Philadelphia chromosome positive chronic myeloid leukemia. Stem Cells (Dayt) 1993;11(suppl 3):104-8.
5. Rosenberg SA. The immunotherapy of solid cancers based on cloning the genes encoding tumor-rejection antigens. Annu Rev Med 1996;47:481-91.
6. Molldrem J, Dermime S, Parker K, et al. Targeted T-cell therapy for human leukemia: cytotoxic T lymphocytes specific for a peptide derived from proteinase 3 preferentially lyse human myeloid leukemia cells. Blood 1996;88:2450-7.
7. Goulmy E. Human minor histocompatibility antigens. Curr Opin Immunol 1996;8:75-81.
8. Dengler R, Munstermann U, al-Batran S, et al. Immunocytochemical and flow cytometric detection of proteinase 3 (myeloblastin) in normal and leukaemic myeloid cells. Br J Haematol 1995;89: 250-7.
9. Molldrem JJ, Clave E, Jiang YZ, et al. Cytotoxic T lymphocytes specific for a non polymorphic proteinase 3 peptide preferentially inhibit chronic myelogeneous leukemia colony-forming units. Blood 1997;90:2529-34.
10. Kirszenbaum M, Djoulah S, Hors J, et al. HLA-G gene polymorphism segregation within CEPH reference families. Hum Immunol 1997;53:140-7.
11. Zweerink HJ, Gammon MC, Utz U, et al. Presentation of endogenous peptides to MHC class I-restricted cytotoxic T lymphocytes in transport deletion mutant T2 cells. J Immunol 1993;150: 1763-71.
12. Parker KC, Bednarek MA, Coligan JE. Scheme for ranking potential HLA-A2 binding peptides based on independent binding of individual peptide side-chains. J Immunol 1994;152:163-75.
13. Sturrock AB, Franklin KF, Rao G, et al. Structure, chromosomal assignment, and expression of the gene for proteinase-3. The Wegener's granulomatosis autoantigen. J Biol Chem 1992;267: 21193-9.
14. Muller-Berat N, Minowada J, Tsuji-Takayama K, et al. The phylogeny of proteinase 3/myeloblastin, the autoantigen in Wegener's granulomatosis, and myeloperoxidase as shown by immunohistochemical studies on human leukemic cell lines. Clin Immunol Immunopathol 1994;70:51-9.
15. Musette P, Labbaye C, Dorner MH, Cayre YE, Casanova JL, Kourilsky P. Wegener's autoantigen and leukemia [Letter]. Blood 1991;77:1398-9.
16. Campanelli D, Melchior M, Fu Y, et al. Cloning of cDNA for proteinase 3: a serine protease, antibiotic, and autoantigen from human neutrophils. J Exp Med 1990;172:1709-15.
17. Jenne DE, Tschopp J, Ludemann J, Utecht B, Gross WL. Wegener's autoantigen decoded [Letter]. Nature 1990;346:520.
18. Bories D, Raynal MC, Solomon DH, Darzynkiewicz Z, Cayre YE. Down-regulation of a serine protease, myeloblastin, causes growth arrest and differentiation of promyelocytic leukemia cells. Cell 1989;59:959-68.