Molecular analysis of the genomic inversion and insertion of AF10 into MLL suggests a single-step event

Genes Chromosomes and Cancer

Volumn 30, Issue 2, 2001, Pages 175-180

  Chaplin, Tracy ^a   Jones, Louise ^a   Debernardi, Silvana ^a   Hill, Alexander S ^a   Lillington, Debra M ^a   Young, Bryan D ^a  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACUTE GRANULOCYTIC LEUKEMIA; ADULT; ARTICLE; CHROMOSOMAL LOCALIZATION; CHROMOSOME 10P; CHROMOSOME INSERTION; CHROMOSOME INVERSION; CHROMOSOME TRANSLOCATION; DNA FLANKING REGION; DNA TRANSPOSITION; EXON; GENE FUSION; GENETIC ANALYSIS; GENOME; HUMAN; MALE; PRIORITY JOURNAL;

EID: 0035167290     PISSN: 10452257     EISSN: None     Source Type: Journal    
DOI: 10.1002/1098-2264(2000)9999:9999<::AID-GCC1073>3.3.CO;2-E     Document Type: Article

References (29)

1. Identification of BCR-ABL fusion on chromosome 9 by fluorescence in situ hybridization in two chronic myeloid leukemia cases
2. BCR/ABL-negative chronic myeloid leukemia with ETV6/ABL fusion
3. Interstitial insertion of AF10 into the ALL1 gene in a case of infant acute lymphoblastic leukemia
4. Location of the BCR-ABL fusion gene on the 9q34 band in two cases of Ph-positive chronic myeloid leukemia
5. Translocation t(10;11) involving the MLL gene in acute myeloid leukemia. Importance of fluorescence in situ hybridization (FISH) analysis
6. Molecular basis of 11q23 rearrangements in hematopoietic malignant proliferations
7. Breakpoint heterogeneity in t(10;11) translocation in AML-M4/M5 resulting in fusion of AF10 and MLL is resolved by fluorescent in situ hybridization analysis
8. Molecular analysis of the CALM/AF10 fusion: Identical rearrangements in acute myeloid leukemia, acute lymphoblastic leukemia and malignant lymphoma
9. A novel type of MLL/AF10 fusion transcript in a child with acute megakaryocytic leukemia (AML-M7) Leukemia
10. Identification and molecular characterisation of CALM/AF10 fusion products in T cell acute lymphoblastic leukemia and acute myeloid leukemia
11. A novel class of zinc finger/leucine zipper genes identified from the molecular cloning of the t(10;11) translocation in acute leukemia
12. The t(10;11) translocation in acute myeloid leukemia (M5) consistently fuses the leucine zipper motif of AF10 onto the HRX gene
13. Molecular analysis of 13 cases of MLL/11q23 secondary acute leukemia and identification of topoisomerase II consensusbinding sequences near the chromosomal breakpoint of a secondary leukemia with the t(4;11)
14. The t(10;11)(p13;q14) in the U937 cell line results in the fusion of the AF10 gene and CALM, encoding a new member of the AP-3 clathrin assembly protein family
15. Sequence analysis of the breakpoint cluster region in the ALL-1 gene involved in acute leukemia
16. A novel MLL-AF10 fusion mRNA variant in a patient with acute myeloid leukemia detected by a new asymmetric reverse transcription PCR method
17. EWS-ERG fusion transcript produced by chromosomal insertion in a Ewing sarcoma
18. Hematologic malignancies with the t(10;11) (p13;q21) have the same molecular event and a variety of morphologic or immunologic phenotypes
19. Insertion (10;11)(p11;q23q24) in two cases of acute monocytic leukemia
20. The t(10;11)(p12;q23) translocation in acute leukaemia: A cytogenetic and clinical study of 20 patients. European 11q23 Workshop participants
21. Ph-negative chronic myeloid leukemia: Molecular analysis of ABL insertion into M-BCR on chromosome 22
22. Consistent detection of CALM-AF10 chimaeric transcripts in haematological malignancies with t(10;11)(p13;q14) and identification of novel transcripts
23. Exon/intron structure of the human ALL-1 (MLL) gene involved in translocations to chromosomal region 11q23 and acute leukaemias
24. The novel activation of ABL by fusion to an ets-related gene, TEL
25. Cytogenetic analysis by in situ hybridization with fluorescently labeled nucleic acid probes
26. Interstitial insertion of varying amounts of ABL-containing genetic material into chromosome 22 in Ph-negative CML
27. ALL-1 tandem duplication in acute myeloid leukemia with a normal karyotype involves homologous recombination between Alu elements
28. A consensus sequence for cleavage by vertebrate DNA topoisomerase II
29. AF10 is split by MLL and HEAB, a human homolog to a putative Caenorhabditis elegans ATP/GTP-binding protein in an invins(10;11)(p12;q23q12)