Immunohistochemical evidence and ultrastructural compartmentalization of a new antioxidant enzyme in the rat substantia nigra

Journal of Neurocytology

Volumn 30, Issue 2, 2001, Pages 97-105

  Fornai, Francesco ^a   Gesi, Marco ^a   Saviozzi, Michela ^a   Lenzi, Paola ^a   Piaggi, Simona ^a   Ferrucci, Michela ^a   Casini, Alessandro ^a  

^a UNIVERSITY OF PISA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIOXIDANT; ASCORBIC ACID; DEHYDROASCORBIC ACID REDUCTASE;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ANALYSIS; ENZYME LOCALIZATION; FEMALE; HYPOTHALAMUS VENTROMEDIAL NUCLEUS; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; NONHUMAN; PRIORITY JOURNAL; RAT; SUBSTANTIA NIGRA; TRANSMISSION ELECTRON MICROSCOPY; VENTRAL TEGMENTUM;

ANIMALS; CELL COMPARTMENTATION; DEHYDROASCORBIC ACID; ELECTROPHORESIS, POLYACRYLAMIDE GEL; FEMALE; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; MICROSCOPY, IMMUNOELECTRON; OXIDOREDUCTASES; RATS; RATS, WISTAR; SUBSTANTIA NIGRA;

ANIMALIA;

EID: 0035166480     PISSN: 03004864     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1011973522055     Document Type: Article

References (49)

1. Reduction of lipid peroxidation in different brain regions by a combination of alpha-tocopherol and ascorbic acid
2. Glutamate neurotoxicity and diseases of the nervous system
3. Excitotoxic cell death
4. Adrenomedullary chromaffin cells as a model to study the neurobiology of ascorbic acid: From monooxygenation to neuromodulation
5. Excitotoxicity, free radicals, and cell membrane changes
6. Differentiation of axon-related Schwann cells in vitro. L-ascorbic acid regulates basal lamina assembly and myelin formation
7. The oxidant stress hypothesis in Parkinson's diseases: Evidence supporting it
8. Substantianigra
9. Species differences in the role of excitatory amino acids in experimental parkinsonism
10. Localization of a glutathione-dependent dehydroascorbate reductase within the central nervous system of the rat
11. Ascorbate is an outstanding antioxidant in human blood plasma
12. Oxidative pathways for catecholamines in the genesis of neuromelanin and cytotoxic quinones
13. Ascorbic acid in the brain
14. A role for substantia nigra pars reticulata in the gaze palsy of progressive supranuclear palsy
15. Oxidants and the central nervous system: Some fundamental questions. Is oxidant damage relevant to Parkinson's disease, Alzheimer's disease, traumatic injury or stroke?
16. Reactive oxygen species and the central nervous system
17. Molecular cloning and functional expression of rat liver glutathione-dependent dehydroascorbate reducrase
18. Ascorbic acid in mesencephalic cultures: Effects on dopaminergic neuron development
19. Arrhythmic firing in dopamine neurons of rat substantia nigra evoked by activation of subthalamic neurons
20. A formaldehyde-glutaraldehyde fixative of high osmolarity for use in electron microscopy
21. Free radicals as mediators of tissue injury and disease
22. Ascorbate modulates glutamate-induced excitation of striatal neurons
23. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
24. Purification and characterization of glutathione-dependent dehydroascorbate-reductase from the rat liver
25. Inhibitory effects of ascorbic acid on dopamine uptake by rat striatal synaptosomes: Relationship to lipid peroxidation and oxidation of protein sulfhydril groups
26. Effect of fixation time and microwave oven heating time on retrieval of the ki-67 antigen from paraffin embedded tissue
27. Glial cells mediate toxicity in glutathione-depleted mesencephalic cultures
28. Ablation of the subthalamic nucleus supports the survival of nigral dopaminergic neurons after nigrostriatal lesions induced by the mitochondrial toxin 3-nitropropionic acid
29. Prevention of dopamine-induced cell death by thiol antioxidants: Possible implications for treatment of Parkinson's disease
30. Localization of a GSH-dependent dehydroascorbate reductase in rat tissues and subcellular fractions
31. Ascorbic acid protects against levodopa-induced neurotoxicity on a catecholamine-rich neuroblastoma cell line
32. Subthalamic nucleus lesion in rats prevents dopaminergic nigral neuron degeneration after striatal 6-OHDA injection: Behavioral and immunohistochemical studies
33. Neuroprotective effect of chronic inactivation of the sub-thalamic nucleus in a rat model of Parkinson's disease
34. A vitamin as a neuromodulator: Ascorbate release into the extracellular fluid of the brain regulates dopaminergic and glutamatergic transmission
35. Oxidative processes and antioxidative defense mechanisms in the aging brain
36. Ascorbate regulation and its neuroprotective role in the brain
37. Differential compartmentalization of brain ascorbate and gluthathione between neurons and glia
38. Axonal branching pattern of neurons of the sub-thalamic nucleus in primates
39. Oxidative stress and mitochondrial dysfunction in neurodegeneration
40. Damage of substantia nigra pars reticulata during pilocarpine-induced status epilepticus in the rat: Immunohistochemical study of neurons, astrocytes, and serum-protein extravasation
41. Oxidative stress in neurodegenerative diseases
42. Basal expression and induction of glutamate decarboxylase and GABA in excitatory granule cells of the rat and monkey hippocampal dentate gyrus
43. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: Procedure and some applications
44. Potential oxidative pathways of brain catecholamines
45. Ascorbic acid reduces the dopamine depletion induced by methamphetamine and the 1-methyl-4-phenyl pyridinium ion
46. Energy stress-induced dopamine loss in glutathione peroxidase-overexpressing transgenic mice and in glutathione-depleted mesencephalic cultures