Effect of antacid pretreatment on the pharmacokinetics of AS-924, a novel ester-type cephem antibiotic - Comparison with cefteram-pivoxil

International Journal of Antimicrobial Agents

Volumn 18, Issue 5, 2001, Pages 477-482

  Totsuka, Kyoichi ^a   Shimizu, Kihachiro ^b   Mori, Nobuhiro ^c   Sugihara, Taisuke ^c   Sakai, Atsushi ^c   Yamaji, Shinya ^c   Michisuji, Yuji ^c   Shinohara, Yumiko ^c   Kubo, Akihiro ^c   Tokuoka, Hiroko ^c  

^a TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

^b ST MARIANNA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c ASAHI KASEI PHARMA CORPORATION   (Japan)

Author keywords

Antacids pretreatment; AS 924; Cefteram pivoxil; Ceftizoxime; Oral cephem antibiotics; Prodrug

Indexed keywords

ANTIBIOTIC AGENT; CARNITINE; CEFTERAM; CEFTERAM PIVOXIL; CEFTIZOXIME; CEFTIZOXIME ALAPIVOXIL; CEFTIZOXIME ARAPIVOXIL; CEPHAM DERIVATIVE; CREATINE; PRODRUG; RANITIDINE; UNCLASSIFIED DRUG;

ADULT; AMINO ACID URINE LEVEL; ARTICLE; CLINICAL TRIAL; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG INACTIVATION; DRUG SOLUBILITY; DRUG STRUCTURE; GASTROINTESTINAL TRACT; HUMAN; HUMAN EXPERIMENT; INTESTINE ABSORPTION; MALE; PH; PRIORITY JOURNAL; URINARY EXCRETION; VOLUNTEER;

ABSORPTION; ADMINISTRATION, ORAL; ADULT; ANTACIDS; ANTI-BACTERIAL AGENTS; CEFMENOXIME; CEFTIZOXIME; DRUG INTERACTIONS; HUMANS; MALE; PRODRUGS; RANITIDINE; URINE;

EID: 0035161288     PISSN: 09248579     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0924-8579(01)00445-9     Document Type: Article

References (10)

1. Effects of food, ceruletide and ranitidine on the pharmacokinetics of the oral cephalosporin S-1108 in humans
2. Influence of food and reduced gastric acidity on the bioavailability of bacampicillin and cefuroxime axetil
3. Effects of ranitidine, metoclopromide, and anisotropine methylbromide on the availability of cefpodoxime proxetil (CS-807) in Japanese healthy subjects
4. Effects of antacids on absorption, excretion and metabolism of cefteram pivoxil
5. Orally active 1-(cyclohexyloxycarbonyloxy) alkyl ester prodrugs of cefotiam
6. Studies on orally active cephalosporin esters. II. Chemical stability of pivaloyloxymethyl esters in phosphate buffer solution
7. Carnitine deficiency induced by pivampicillin and pivmecillinam therapy
8. Determination of pivaloylcarnitine in human plasma and urine by high-performance liquid chromatography with fluorescence detection