Development of acyclovir-resistant herpes simplex virus early during the treatment of herpes neonatorum

Pediatric Infectious Disease Journal

Volumn 20, Issue 11, 2001, Pages 1094-1097

  Levin, Myron J ^a   Weinberg, Adriana ^a   Leary, Jeffry J ^b   Sarisky, Robert T ^b  

^a University of Colorado Denver and Children s Hospital Colorado   (United States)

^b GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Antiviral resistance; Neonatal herpes simples virus infection

Indexed keywords

ACICLOVIR; THYMIDINE KINASE;

ARTICLE; CASE REPORT; DRUG RESISTANCE; DRUG TOLERABILITY; GENE MUTATION; GENETIC ANALYSIS; GENOTYPE; HERPES SIMPLEX VIRUS; HUMAN; MALE; NEWBORN; NEWBORN INFECTION; PRIORITY JOURNAL; SEQUENCE ANALYSIS; VIRUS INFECTION; VIRUS ISOLATION;

ACYCLOVIR; ANTIVIRAL AGENTS; AUTOPSY; DISEASE TRANSMISSION, VERTICAL; DNA, VIRAL; DRUG RESISTANCE, VIRAL; FATAL OUTCOME; FEMALE; FOSCARNET; GENOTYPE; HERPES SIMPLEX; HUMANS; IMMUNOENZYME TECHNIQUES; INFANT, NEWBORN; MALE; MICROBIAL SENSITIVITY TESTS; MUTATION; POLYMERASE CHAIN REACTION; PREGNANCY; SIMPLEXVIRUS; THYMIDINE KINASE;

EID: 0035164950     PISSN: 08913668     EISSN: None     Source Type: Journal    
DOI: 10.1097/00006454-200111000-00021     Document Type: Article

References (12)

1. Sensitivity monitoring of clinical isolates of herpes simplex virus to acyclovir
2. Survey of resistance of herpes simplex virus to acyclovir in northwest England
3. Antiviral susceptibilities of herpes simplex virus isolates from infants with recurrent mucocutaneous lesions after neonatal infection
4. Characterization of an acyclovir-resistant herpes simplex virus type 2 strain isolated from a premature neonate
5. Herpes simplex virus type 1 DNA in cerebrospinal fluid of a patient with Mollaret's meningitis
6. In vitro activities of penciclovir and acyclovir in vitro against herpes simplex types 1 and 2
7. Atypical herpes simplex virus encephalitis diagnosed by PCR amplification of viral DNA from CSF
8. A rapid screen test for in vitro susceptibility of clinical herpes simplex virus isolates
9. Role of genotypic analysis of the thymidine kinase gene of herpes simplex virus for determination of neurovirulence and resistance to acyclovir
10. Homopolymer mutational hot spots mediate herpes simplex virus resistance to acyclovir
11. Phenotypic and genotypic characterization of acyclovir-resistant herpes simplex viruses from immunocompromised patients
12. Disseminated candidal infections and intravenous hydrocortisone in preterm infants