Gene therapy vectors harboring AFP regulatory sequences: Preparation of an adenoviral vector

Applied Biochemistry and Biotechnology - Part B Molecular Biotechnology

Volumn 19, Issue 3, 2001, Pages 323-330

  Kaneko, S ^a   Tamaoki, T ^a  

^a KANAZAWA UNIVERSITY   (Japan)

Author keywords

Fetoprotein (AFP); Adenoviral vector; Gene therapy; Hepatocellular carcinoma (HCC)

Indexed keywords

ALPHA FETOPROTEIN; GANCICLOVIR; THYMIDINE KINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DNA VECTOR; GENE SEQUENCE; GENE THERAPY; GENETIC TRANSCRIPTION; HERPES SIMPLEX VIRUS; HUMAN; HUMAN CELL; LIVER CELL CARCINOMA; MOUSE; NONHUMAN; NUDE MOUSE; REGULATOR GENE; SILENCER GENE; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION;

ALPHA-FETOPROTEINS; GENE THERAPY; GENETIC VECTORS; RECOMBINANT PROTEINS; REGULATORY SEQUENCES, NUCLEIC ACID;

ANIMALIA; HERPES; MUS MUSCULUS; SIMPLEXVIRUS;

EID: 0035164576     PISSN: 10736085     EISSN: None     Source Type: Journal    
DOI: 10.1385/MB:19:3:323     Document Type: Article

References (34)

1. The human α-fetoprotein gene: Sequence organization and the 5′ flanking region
2. Cell-specific enhancer activity in a far upstream region of the human α-fetoprotein gene
3. Interaction of a hepatoma-specific nuclear factor with transcription regulatory sequences of the human α-fetoprotein and albumin genes
4. A position-dependent silencer plays a major role in repressing α-fetoprotein expression in human hepatoma
5. Transcriptional regulation of α-fetoprotein, expression by dexamethasone in human hepatoma cells
6. Tissue-specific transcription of the mouse α-fetoprotein gene promoter is dependent on HNF1
7. Molecular mechanisms of liver specific albumin and α-fetoprotein gene regulation: A review
8. Members of the CAAT/enhancer-binding protein, hepatocyte nuclear factor-1 and nuclear factor-1 families can differentially modulate the activities of the rat α-fetoprotein promoter and enhancer
9. A human α-fetoprotein enhancer-binding protein, ATBF1, contains four homeodomains and seventeen zinc fingers
10. ATDP1, a multiple homeodomain zinc finger protein, selectively down-regulates AT-rich elements of the human α-fetoprotein gene
11. Fine-structure mapping of the three mouse α-fetoprotein gene enhancers
12. Enhancer, repressor, and promoter specificities combine to regulate the rat α-fetoprotein gene
13. In vivo therapy of hepatocellular carcinoma with a tumor specific adenoviral vector expressing interleukin-2
14. Postnatal repression of the α-fetoprotein gene is enhancer independent
15. Dominant negative regulation of the mouse α-fetoprotein gene in adult liver
16. The zonal expression of α-fetoprotein transgenes in the livers of adult mice
17. A possible mechanism of inverse developmental regulation of α-fetoprotein and albumin genes. Studies with epidermal growth factor and phorbol ester
18. Adenovirus-mediated gene therapy of hepatocellular carcinoma using cancer-specific gene expression
19. Gene therapy for hepatocellular carcinoma: Chemosensitivity conferred by adenovirus-mediated transfer of the HSV-1 thymidine kinase gene
20. Gene therapy for alpha-fetoprotein-producing human hepatoma cells by adenovirus-mediated transfer of the herpes simplex virus thymidine kinase gene
21. In vitro and in vivo hepatoma cell-specific expression of a gene transferred with an adenoviral vector
22. Deoxycytidine kinase from calf thymus
23. Evaluation of the efficacy and safety of in vitro adenovirus-cDNA
24. Adenovirus mediated expression of therapeutic plasma levels of human factor IX in mice
25. Enhanced and specific gene expression via tiseue, specific production of Cre recombinase using adenovirus vector
26. Cre-stimulated recombination at loxP-containing DNA sequences placed into the mammalian genome
27. Recombinase-mediated gene activation and site-specific integration in mammalian cells
28. Efficient gene activation in mammalian cells by using recombinant adenovirus expressing site-specific Cre recombinase
29. Efficient selection for high-expression transfectants with a novel eukaryotic vector
30. Regulated expression of artificial chimeric gene contained in retroviral vectors: Implications for virus-directed enzyme produrg therapy (VDEPT) and other gene therapy applications
31. Gene therapy for hepatoma cells using a retrovirus vector carrying herpes simplex virus thymidine kinase gene under the control of alpha-fetoprotein gene promoter
32. Retrovirus-mediated gene therapy for hepatocellular carcinoma: Selective and enhanced suicide gene expression regulated by human α-fetoprotein enhancer directly linked to its promoter
33. Selective killing of AFP-positive hepatocellular carcinoma cells by adeno-associated virus transfer of the herpes simplex virus thymidine kinase gene
34. Tissue-specific expression of herpes simplex virus thymidine kinase gene delivered by adeno-associated virus inhibits the growth of human hepatocellular carcinoma in athymic mice