Regulated expression of artificial chimeric genes contained in retroviral vectors: Implications for virus-directed enzyme prodrug therapy (VDEPT) and other gene therapy applications

Journal of Drug Targeting

Volumn 3, Issue 5, 1996, Pages 349-356

  Huber, Brian E ^a   Richards, Cynthia A ^a  

^a GLAXOSMITHKLINE   (United States)

Author keywords

Albumin expression; Hepatoma retroviral vectors; Sucide gene; Thymidine kinase

Indexed keywords

ALBUMIN; ALPHA FETOPROTEIN; PRODRUG; THYMIDINE KINASE;

ARTICLE; CELL CLONE; CHIMERA; CONTROLLED STUDY; EXPRESSION VECTOR; GENE EXPRESSION REGULATION; GENE THERAPY; HEPATOBLASTOMA; HUMAN; HUMAN CELL; PRIORITY JOURNAL; RETROVIRUS; TRANSCRIPTION REGULATION; VARICELLA ZOSTER VIRUS; VIRUS DNA CELL DNA INTERACTION;

EID: 0030069289     PISSN: 1061186X     EISSN: None     Source Type: Journal    
DOI: 10.3109/10611869608996826     Document Type: Article

References (25)

1. Anderson W.F. Human gene therapy. Science 256:808-813 (1992)
2. Miller, A.D. Progress toward human gene therapy. Blood 76:271-278 (1990).
3. Verma, I.M. Gene therapy. Scientific American (November) 68-84 (1990).
4. Friedmann, T. Progress toward human gene therapy. Science 244:1275-1281 (1989).
5. Huber, B.E., Richards, C.A. and Krenitsky, T.A. Retroviral-mediated gene therapy for the treatment of hepatocellular carcinoma: An innovative approach for cancer therapy. Proc. Natl. Acad. Sci USA 88:8039-8043 (1991).
6. Richards, C.A., Wolberg, A.S., and Huber, B.E. The transcriptional control region of the human carcinoembryonic antigen gene: DNA sequence and homology studies. DNA Sequence, 4:185-196 (1993).
7. Austin, H.A., and Huber, B.E A first step in the development of gene therapy for colorectal carcinoma: Cloning, sequencing, and expression of Escherichia coli cytosine deaminase. Mol. Pharm. 43:380-387 (1993).
8. Huber, B.E., Austin, E.A., Good, S.S., Knick, V.C., Tibbels, S., and Richards, C.A. In vivo antitumor activity of 5-fluorocytosine on human colorectal carcinoma cells genetically modified to express cytosine deaminase. Cancer Res. 53:4619-4626 (1993).
9. Richards, C.A. and Huber, B.E, Generation of a transgenic model for retrovirus-mediated gene therapy for hepatocellular carcinoma is thwarted by the lack of transgene expression. Human Gene Therapy 4:143-150 (1993).
10. Huber, B.E., Austin, E.A., Richards, C.A., Davis, S.T., and Good, S.S. Metabolism of 5-flurocytosine to 5-fluorouracil in human colorectal rumor cells transduced with the cytosine deaminase gene: Significant antitumor effects when only a small percentage of tumor cells express cytosine deaminase. Proc. Natl. Acad. Sci. USA. 91:8302-8306 (1994).
11. Richards, C.A., Austin, E.A., and Huber, B.E. Transcriptional regulatory sequences of carcinoembryonic antigen: Identification and use with cytosine deaminase for tumor-specific gene therapy. Human Gene Therapy (in press).
12. Knowles, B.B., Howe, C.C., and Aden, D.P., Human hepatocellular carcinoma cell lines secrete the major plasma proteins and hepatitis B surface antigen. Science 209:497-499 (1980).
13. Huber, B.E., Dearfield, K.L., Williams, J.R., Heilman, C.A., Thorgeirsson, S.S. Tumorigenicity and transcriptional modulation of C-Myc and N-ras oncogenes in a human hepatoma cell line. Cancer Res 45:4322-4329 (1985).
14. Averett, D.A., Koszalka, G.W., Fyfe, J.A., Roberts, G.B., Purifoy, D.J.M., and Krenitsky, T.A. 6-Methoxypurine arabinoside as a selective and potent inhibitor of varicella-zoster virus. Antimicrob. Agents Chemother. 35:851-857 (1991).
15. Kotani, H., Newton, P.B., Zhang, S., Chiang, Y.L., Otto, E., Weaver, L., Blaese, R.M., Anderson, W.F., McGarrity, G.J. Improved methods of retroviral vector transduction and production for gene therapy. Human Gene Therapy 5:19-28 (1994).
16. Donahue, R.E., Kessler, S.W., Bondine, D., McDonagh, K., Dunbar, C., Goodman, S., Agricola, B., Byrne, E., Raffeld, M., Moen, R., Bacher, J., Zsebo, K.M., and Nienhuis, A.W. Helper virus induced T-cell lymphoma in non-human primates after retroviral mediated gene transfer. J. Exp. Med. 176:1125-1135 (1992).
17. Kay, M.A., Li, Q., Liu, T.J., Leland, F., Toman, C., Finegold, M., and Woo, S.L. Hepatic gene_therapy: persistent expression of human α-1-antitrypsin in mice after direct gene delivery in vivo. Human Gene Therapy 3:641-647 (1992).
18. Peng, H., Armentano, D., MacKenzie-Gtaham, L., Shen, R.F., Darlington, Ledley, F.D., and Woo, S.L.C. Retroviral-mediated gene transfer and expression of human phenylalanine hydroxylase in primary mouse hepatocytes. Proc. Natl. Acad. Sci. USA 85:8146-8150 (1988).
19. Cone, R.D., Weber-Benarous, A., Baorto, D., and Mulligan, R.C. Regulated expression of a complete human B-globin gene encoded by a transmissible retrovirus vector. Mol. Cell Biol. 7:887-897 (1987).
20. Andersen, J.K Garber, D.A., Meaney, C.A., and Breakfield, X.O. Gene transfer into mammalian central nervous system using herpes virus vectors: extended expression of bacterial Lac Z in neurons using the neuron-specific enolase promoter. Human Gene Therapy 3:487-499, (1992).
21. Vile, R.G., and Hart, I.R. In vitro and in vivo targeting of gene expression to melanoma cells. Cancer Res. 53:962-967 (1993).
22. Smith, M.J., Rousculp, M.D., Goldsmith, K.T., Curiel, D.T., and Carver, R. L, Surfactant protein A-directed toxin gene kills lung cancer cells in vitro Hum. Gene Therapy. 5:29-35 (1994)
23. Osaki, T , Tanio, Y., Tachibana, I., Hosoe, S., Kumagai, T., Kawase, I , Oikawa, S., and Kishimoto, T. Gene therapy for carcinoembryonic antigen-producing human lung cancer cells by cell type-specific expression of Herpes Simplex Virus thymidine kinase gene. Cancer Res. 54:5258-5261 (1994).
24. Manome, Y , Abe, M., Hagen, M.F., Fine, H.A., and Kufe, D.W., Enhancer sequences of the DF3 gene regulate expression of the herpes simplex virus thymide kinase gene and confer sensitivity of human breast cancer cells to ganciclovir. Cancer Res. 54:5408-5413 (1994).
25. Nakata, K., Motomura, M., Nakabayashi, H., Ido, A., and Tamaoki, T. A possible mecanism of inverse developmental regulation of a-fetoprotein and albumin genes: studies with epidermal growth factor and phorbol ester. J. Biol. Cham 267:1331-1334 (1992).