A novel monoclonal antibody against the extracellular domain of GPIbβ modulates vWF mediated platelet adhesion

Thrombosis and Haemostasis

Volumn 86, Issue 5, 2001, Pages 1238-1248

  Perrault, C ^a   Moog, S ^a   Rubinstein, E ^a   Santer, M ^a   Baas, M J ^a   De La Salle, C ^a   Ravanat, C ^a   Dambach, J ^a   Freund, M ^a   Santoso, S ^a   Cazenave, J P ^a   Lanza, F ^a  

^a INSERM   (France)

Author keywords

Adhesion; GPIb V IX complex; Von Willebrand factor

Indexed keywords

ADENOSINE DIPHOSPHATE; ANTIBODY; BETA GLYCOPROTEIN IB; BOTROCETIN; COLLAGEN; CYSTEINE; GLYCOPROTEIN; GLYCOPROTEIN IB; GLYCOPROTEIN IX; GLYCOPROTEIN V; LEUCINE; LIGAND; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY GI27; MONOCLONAL ANTIBODY RAM 1; RISTOCETIN; THROMBIN; THROMBOCYTE RECEPTOR; UNCLASSIFIED DRUG; VON WILLEBRAND FACTOR; ANTITHROMBOCYTIC AGENT; EPITOPE; PLATELET GLYCOPROTEIN GPIB IX COMPLEX; THROMBIN RECEPTOR;

ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL LYSATE; CHO CELL; COMPLEX FORMATION; CONTROLLED STUDY; DNA FLANKING REGION; DRUG EFFECT; EPITOPE MAPPING; EXTRACELLULAR SPACE; GENE DELETION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; MALE; MODULATION; MOUSE; NONHUMAN; PRECIPITATION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN INTERACTION; SHEAR RATE; THROMBOCYTE; THROMBOCYTE ADHESION; THROMBOCYTE AGGLUTINATION; VELOCITY; WESTERN BLOTTING; ANIMAL; CHEMISTRY; DRUG INTERACTION; IMMUNOLOGY; ISOLATION AND PURIFICATION; METABOLISM; PHYSIOLOGY; PROTEIN BINDING; PROTEIN TERTIARY STRUCTURE; RAT; SPECIES DIFFERENCE; THROMBOCYTE ADHESIVENESS; THROMBOCYTE AGGREGATION;

ANIMAL; ANTIBODIES, MONOCLONAL; BLOOD PLATELETS; DRUG INTERACTIONS; EPITOPES; HUMAN; MALE; MICE; PLATELET ADHESIVENESS; PLATELET AGGREGATION; PLATELET AGGREGATION INHIBITORS; PLATELET GLYCOPROTEIN GPIB-IX COMPLEX; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RATS; SPECIES SPECIFICITY; SUPPORT, NON-U.S. GOV'T; VON WILLEBRAND FACTOR;

EID: 0035164336     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0037-1616057     Document Type: Article

References (44)

1. Old concepts and new developments in the study of platelet aggregation
2. A revised model of platelet aggregation
3. Platelet and shear stress
4. Initiation of platelet adhesion by arrest onto fibrinogen or translocation on von Willebrand factor
5. Ristocetin and botrocetin involve two distinct domains of von Willebrand factor for binding to platelet membrane GPIb
6. The platelet glycoprotein Ib-IX complex
7. Identification of a site in the α chain of platelet GPIb that participates to von Willebrand factor binding
8. Localization and characterization of an α thrombin-binding site on platelet GPIbα
9. Identification of a region in the cytoplasmic domain of the platelet GPIb/IX complex that binds to purified actin-binding protein
10. Binding of purified 14-3-3ζ signalling protein to discrete amino acid sequences within the cytoplasmic domain of the platelet membrane GPIb-IX-V complex
11. Human signalling protein 14-3-3ζ interacts with platelet glycoprotein Ib subunits Ibα and Ibβ
12. The cytoplasmic domain of the α-subunit of glycoprotein (GP) Ib mediates attachment of the entire GPIb-IX complex to the cytoskeleton and regulates von Willebrand factor induced changes in cell morphology
13. 14-3-3 and its possible role in co-ordinating multiple signalling pathways
14. Efficient plasma membrane expression of a functional platelet GPIb-IX complex requires the presence of its three subunits
15. GPIbβ is the critical subunit linking GPIbα and GPIX in the GPIb-IX complex
16. Bernard-Soulier syndrome
17. Platelet GPIbβ is phosphorylated on serine 166 by cyclic AMP-dependent kinase
18. Single amino acid substitution in human GPIbβ is responsible for the formation of the platelet-specific alloantigen Iya
19. Electrophoretic studies on molecular defects of von Willebrand factor and platelet GPIIb-IIIa which antibodies produced in egg yolf from laying hens
20. Adrenaline activates human platelets but is not an aggregating agent
21. GPV is a marker of in vivo platelet activation-study in a rat thrombosis model
22. Role of the leucine-rich domain of platelet GPIbα in correct post-translational processing: The Nancy I Bernard-Soulier mutation expressed on CHO cells
23. The von Willebrand factor-GPIb/V/IX interaction induces actin polymerization and cytoskeletal reorganization in rolling platelets and GPIb/V/IX-transfected cells
24. GPIb-IX-transfected cells roll on a von Willebrand factor matrix under flow
25. Studies with a murine monoclonal antibody that abolishes ristocetin-induced binding of von Willebrand factor to platelets: Additional evidence in support of GPIb as a platelet receptor for von Willebrand factor
26. A murine anti-GPIb complex monoclonal antibody, SZ2, inhibits platelet aggregation induced by both ristocetin and collagen
27. Diagnosis of Bernard-Soulier syndrome and Glanzmann's thrombasthenia with a monoclonal assay on whole blood
28. Characterization of the gene encoding mouse platelet GPIbβ
29. Structural characterization and chromosomal location of the gene encoding human platelet GPIbβ
30. Cloning of the murine platelet GPIbα gene highlighting species-specific platelet adhesion
31. Reciprocal expression of infant- and adult-preferring transcripts of CDCrel-1 septin gene in the rat neocortex
32. Identification of the disulphide bonds in human platelet glycocalicin
33. Platelet GPIX associates with GPIbα in the platelet membrane GPIb complex
34. Identification of a mutation in a GATA binding site of the platelet GPIbβ promotor resulting in the Bernard-Soulier syndrome
35. The critical interaction of GPIbβ with GPIX-A genetic cause of Bernard-Soulier syndrome
36. A novel missense mutation in GPIbβ prevents the normal maturation and surface expression of the GPIb-IX-V complex in a patient with the Bernard-Soulier syndrome
37. Surface expression of GPIbα is dependent on GPIbβ: Evidence from a novel mutation causing Bernard-Soulier syndrome
38. Homozygous Pro74→Arg mutation in the platelet GPIbβ gene associated with Bernard-Soulier syndrome
39. Missense mutations of the GPIbβ gene impairing the GPIb α/β disulfide linkage in a family with giant platelet disorder
40. Structure of the GPIb/IX complex from platelet membranes
41. Structure and function of platelet membrane GPIb and GPV. Effects of leukocyte elastase and other proteases on platelets response to von Willebrand factor and thrombin
42. Identification of critical antigen-specific mechanisms in the development of immune thrombocytopenic purpura in mice
43. Differential effects of monoclonal antibodies to rat GPIIb/IIIa, GPIbα or GPV on platelet function and in vivo survival
44. Antithrombotic effect of platelet GPIb-blocking monoclonal antibody Fab fragments in nonhuman primates