Influence of aldosterone vs endothelin receptor antagonism on renovascular function in liquorice-induced hypertension

Nephrology Dialysis Transplantation

Volumn 16, Issue 11, 2001, Pages 2146-2151

  Quaschning, Thomas ^a   Ruschitzka, Frank ^a   Niggli, Bernhard ^a   Lunt, Carolyn M B ^a   Shaw, Sidney ^b   Christ, Michael ^c   Wehling, Martin ^c   Lüscher, Thomas F ^a,d  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b UNIVERSITY OF BERN   (Switzerland)

^c UNIVERSITY OF MANNHEIM   (Germany)

^d UNIVERSITY HOSPITAL ZURICH   (Switzerland)

Author keywords

Endothelin 1; Endothelium; Glycyrrhizic acid; Liquorice; Nitric oxide

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE; ACETYLCHOLINE; ALDOSTERONE; ALDOSTERONE ANTAGONIST; DARUSENTAN; DRINKING WATER; ENDOTHELIN A RECEPTOR ANTAGONIST; GLUCOCORTICOID; GLYCYRRHIZIC ACID; MINERALOCORTICOID RECEPTOR; NORADRENALIN; PLACEBO; SODIUM; SPIRONOLACTONE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY CONSTRICTION; ARTERY DILATATION; ARTICLE; BLOOD PRESSURE REGULATION; BLOOD VESSEL FUNCTION; CARDIOVASCULAR DISEASE; COMPARATIVE STUDY; CONTROLLED STUDY; DISEASE ASSOCIATION; DOSE RESPONSE; ENZYME ACTIVITY; ENZYME DEFECT; ENZYME INHIBITION; HYPERTENSION; ISOLATED ARTERY; ISOMETRICS; KIDNEY BLOOD VESSEL; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; RAT STRAIN; RENAL ARTERY; SODIUM RETENTION; VASCULAR ENDOTHELIUM;

EID: 0035163847     PISSN: 09310509     EISSN: None     Source Type: Journal    
DOI: 10.1093/ndt/16.11.2146     Document Type: Article

References (25)

1. A chimaeric 11 beta-hydroxylase/aldosterone synthase gene causes glucocorticoid-remediable aldosteronism and human hypertension
2. Human hypertension caused by mutations in the kidney isozyme of 11 beta-hydroxysteroid dehydrogenase
3. Cortisol and hypertension
4. Physiologically based pharmacokinetic modeling of glycyrrhizic acid, a compound subject to presystemic metabolism and enterohepatic cycling
5. 11beta-hydroxysteroid dehydrogenase in cultured human vascular cells. Possible role in the development of hypertension
6. Evidence of coexisting changes in 11 beta-hydroxysteroid dehydrogenase and 5 beta-reductase activity in subjects with untreated essential hypertension
7. Increased activation of sympathetic nervous system and endothelin by mental stress in normotensive offspring of hypertensive parents
8. 2+ channels
9. ET(A) receptor blockade prevents increased tissue endothelin-1, vascular hypertrophy, and endothelial dysfunction in salt-sensitive hypertension
10. The effect of an endothelin-receptor antagonist, bosentan, on blood pressure in patients with essential hypertension
11. Spironolactone increases nitric oxide bioactivity, improves endothelial vasodilator dysfunction, and suppresses vascular angiotensin I/angiotensin II conversion in patients with chronic heart failure
12. Mineralocorticoid receptor blockade in chronic heart failure
13. The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators
14. Mechanisms of ET-1 potentiation of angiotensin II stimulation of aldosterone production
15. Regulation of aldosterone secretion in patients with chronic congestive heart failure by endothelins
16. Aldosterone receptor antagonism normalizes vascular function in liquorice-induced hypertension
17. Increased vasodilator responses to acetylcholine in psychosocial hypertensive mice
18. Difference between endothelium-dependent relaxation in arterial and in venous coronary bypass grafts
19. Some statistical methods useful in circulation research
20. Role of the 11beta-hydroxysteroid dehydrogenase type 2 in blood pressure regulation
21. Structure and mechanism of action and inhibition of steroid dehydrogenase enzymes involved in hypertension
22. A receptor antagonism prevents vascular dysfunction and hypertension induced by 11β-hydroxysteroid dehydrogenase inhibition. Role of nitric oxide
23. Endothelium-dependent responses in carotid and renal arteries of normotensive and hypertensive rats
24. Mechanical properties of mesenteric resistance arteries from Dahl salt-resistant and salt-sensitive rats: Role of endothelin-1
25. Aldosterone antagonists in hypertension and heart failure