Aldosterone receptor antagonism normalizes vascular function in liquorice-induced hypertension

Hypertension

Volumn 37, Issue 2 II, 2001, Pages 801-805

  Quaschning, Thomas ^a   Ruschitzka, Frank ^b   Shaw, Sidney ^c   Lüscher, Thomas F ^b  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^c UNIVERSITY OF BERN   (Switzerland)

Author keywords

11 hydroxysteroid dehydrogenase; Endothelin 1, endothelium; Glycyrrhizic acid; Nitric oxide

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE; 11BETA HYDROXYSTEROID DEHYDROGENASE INHIBITOR; ALDOSTERONE ANTAGONIST; ALDOSTERONE RECEPTOR; ENDOTHELIN 1; EPLERENONE; GLYCYRRHIZIC ACID; NITRATE; NITRIC OXIDE SYNTHASE; PLACEBO; SPIRONOLACTONE; UNCLASSIFIED DRUG;

ALDOSTERONE RELEASE; ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; CONFERENCE PAPER; CONTROLLED STUDY; DRUG MECHANISM; DRUG RECEPTOR BINDING; GLYCYRRHIZA; HORMONE RECEPTOR INTERACTION; HYPERTENSION; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONTENT; RAT; RECEPTOR BLOCKING;

EID: 0035092626     PISSN: 0194911X     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.hyp.37.2.801     Document Type: Conference Paper

References (39)

1. A chimaeric 11β-hydroxylase/aldosterone synthase gene causes glucocorticoid-remediable aldosteronism and human hypertension
2. Syndrome of apparent mineralocorticoid excess: A defect in the cortisol-cortisone shuttle
3. Human hypertension caused by mutations in the kidney isozyme of 11β-hydroxysteroid dehydrogenase
4. 11β-Hydroxysteroid dehydrogenase in cultured human vascular cells: Possible role in the development of hypertension
5. Localization of 2 11β-OH steroid dehydrogenase isoforms in aortic endothelial cells
6. Evidence of coexisting changes in 11β-hydroxysteroid dehydrogenase and 5β-reductase activity in subjects with untreated essential hypertension
7. Increased activation of sympathetic nervous system and endothelin by mental stress in normotensive offspring of hypertensive parents
8. Vasodilatation to acetylcholine in primary and secondary forms of human hypertension
9. c+ channels
10. ET(A) receptor blockade prevents increased tissue endothelin-1, vascular hypertrophy, and endothelial dysfunction in salt-sensitive hypertension
11. Spironolactone increases nitric oxide bioactivity, improves endothelial vasodilator dysfunction, and suppresses vascular angiotensin I/angiotensin II conversion in patients with chronic heart failure
12. Efficacy and tolerance of spironolactone in essential hypertension
13. Spironolactone versus nifedipine in essential hypertension
14. Effects of adding spironolactone to an angiotensin-converting enzyme inhibitor in chronic congestive heart failure secondary to coronary artery disease
15. Mineralocorticoid receptor blockade in chronic heart failure
16. Aldosterone and heart failure
17. The effect of spironolactone on morbidity and mortality in patients with severe heart failure: Randomized Aldactone Evaluation Study Investigators
18. Spironolactone: Renaissance of anti-aldosterone therapy in heart failure?
19. Mineralocorticoid receptor antagonists: The evolution of utility and pharmacology
20. Mechanisms of ET-1 potentiation of angiotensin II stimulation of aldosterone production
21. Endothelin in experimental congestive heart failure in the anesthetized dog
22. Regulation of aldosterone secretion in patients with chronic congestive heart failure by endothelins
23. Increased vasodilator responses to acetylcholine in psychosocial hypertensive mice
24. Difference between endothelium-dependent relaxation in arterial and in venous coronary bypass grafts
25. Critical factors in the radioimmunoassay of endothelin-1, endothelin-3, and big endothelin-1 in human plasma
26. Regulation of aldosterone secretion in anephric patients
27. Basal nitric oxide synthesis in essential hypertension
28. Endothelin ETA receptor blockade restores NO-mediated endothelial function and inhibits atherosclerosis in apolipoprotein E-deficient mice
29. Some statistical methods useful in Circ Res
30. Role of the 11β-hydroxysteroid dehydrogenase type 2 in blood pressure regulation
31. Enhanced expression of endothelin-1 gene in resistance arteries in severe human essential hypertension
32. Racial differences in plasma endothelin-1 concentrations in individuals with essential hypertension
33. Structure and function of small arteries in salt-induced hypertension: Effects of chronic endothelin-subtype-A-receptor blockade
34. Evidence for a paracrine role of adrenomedullin in the physiological resetting of aldosterone secretion by rat adrenal zona glomerulosa
35. Aldosterone antagonists in hypertension and heart failure
36. Extra-adrenal mineralocorticoids and cardiovascular tissue
37. Aldosterone and spironolactone in heart failure
38. Cortisol and hypertension