Bioequivalence and relative bioavailability of three estradiol and norethisterone acetate-containing hormone replacement therapy tablets

International Journal of Clinical Pharmacology and Therapeutics

Volumn 39, Issue 1, 2001, Pages 41-46

  Zdravkovic, M ^a   Muller M ^a   Larsen, S ^a   Degenkolb, J ^a   Pabst, G ^a  

^a NOVO NORDISK A S   (Denmark)

Author keywords

Activelle ; Bioequivalence; Hormone replacement therapy; Novofem ; Trisequens

Indexed keywords

ESTRADIOL; ESTRADIOL PLUS NORETHISTERONE ACETATE; ESTROGEN; NORETHISTERONE ACETATE; NOVOFEM; TRISEQUENS; UNCLASSIFIED DRUG;

ADULT; AGED; AREA UNDER THE CURVE; ARTICLE; BIOAVAILABILITY; BIOEQUIVALENCE; BLOOD SAMPLING; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DRUG HALF LIFE; FEMALE; HORMONE SUBSTITUTION; HUMAN; OVARIECTOMY; POSTMENOPAUSE; PREGNANCY TEST; RANDOMIZED CONTROLLED TRIAL; SUBSTITUTION THERAPY; TABLET;

EID: 0035155791     PISSN: 09461965     EISSN: None     Source Type: Journal    
DOI: 10.5414/CPP39041     Document Type: Article

References (8)

1. Hormone replacement therapy
2. Cytochrome P450 3A4: Regulation and role in drug metabolism
3. Pharmacokinetics of oestrogens and progestogens
4. Pharmacokinetics of oral 17-β-estradiol
5. A comparison of the two one-sided test procedures and the power approach for assessing the equivalence of average bioavailability
6. In vitro and in vivo drug interactions involving human CYP3A
7. Chapter 17. Estrogens and progestins