Improved gas chromatography-mass spectrometry method for simultaneous identification and quantification of opiates in urine as propionyl and oxime derivatives

Clinical Chemistry

Volumn 47, Issue 1, 2001, Pages 127-129

  Broussard, L A ^a   Presley, L C ^a   Tanous, M ^a   Queen, C ^a  

^a LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CODEINE; HYDROCODONE; HYDROMORPHONE; MORPHINE; OPIATE; OXIME; OXYMORPHONE;

ACCURACY; ANALYTIC METHOD; ARTICLE; CALIBRATION; DIAGNOSTIC TEST; DRUG DETERMINATION; GAS CHROMATOGRAPHY; HUMAN; HYDROLYSIS; ION MONITORING; MASS SPECTROMETRY; QUANTITATIVE ASSAY; REPRODUCIBILITY; URINALYSIS;

EID: 0035154756     PISSN: 00099147     EISSN: None     Source Type: Journal    
DOI: 10.1093/clinchem/47.1.127     Document Type: Article

References (11)

1. Confirmatory tests for drugs in the workplace by gas chromatography-mass spectrometry
2. Gas chromatographic-mass spectrometric procedures used for the identification and determination of morphine, codeine and 6-monoacetylmorphine
3. Comparison of derivatives for determination of codeine and morphine by gas chromatography/mass spectrometry
4. A closer look at acetyl and pentafluoropropionyl derivatives for quantitative analysis of morphine and codeine by gas chromatography/mass spectrometry
5. Comparison of four derivatizing reagents for 6 acetylmorphine GC/MS analysis in urine
6. Simultaneous identification and quantitation of codeine, morphine, hydrocodone, and hydromorphone in urine as trimethylsilyl and oxime derivatives by gas chromatography-mass spectrometry
7. Improved GC/MS analysis of opiates with use of oxime-TMS derivatives
8. GC-MS confirmation of codeine, morphine, 6-acetylmorphine, hydrocodone, hydromorphone, oxycodone, and oxymorphone in urine
9. Simultaneous analysis of opiates in urine by SPE and GC/MS with stabilization of keto-opiates via conversion to oxime derivative
10. Improved GC/MS method for simultaneous identification and quantitation of opiates in urine as propionyl and oxime derivatives
11. Solid phase extraction of opiates in urine using the Zymark Rapid Trace and derivatization with pentafluorobenzylhydroxylamine and propionic anhydride followed by GC/MS analysis