Role of the UL25 gene product in packaging DNA into the herpes simplex virus capsid: Location of UL25 product in the capsid and demonstration that it binds DNA

Journal of Virology

Volumn 75, Issue 3, 2001, Pages 1427-1436

  Ogasawara, M ^a   Suzutani, T ^a   Yoshida, I ^a   Azuma, M ^a  

^a ASAHIKAWA MEDICAL COLLEGE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; GENE PRODUCT; GREEN FLUORESCENT PROTEIN; VIRUS DNA; VIRUS PROTEIN;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CERCOPITHECIDAE; CONTROLLED STUDY; DNA BINDING; DNA PACKAGING; FETUS; HERPES SIMPLEX VIRUS; HUMAN; HUMAN CELL; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; VIRUS CAPSID;

ANIMALS; CAPSID; CELL NUCLEUS; CERCOPITHECUS AETHIOPS; DNA, VIRAL; HELA CELLS; HERPESVIRUS 1, HUMAN; HUMANS; VERO CELLS; VIRUS ASSEMBLY;

EID: 0035152181     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.75.3.1427-1436.2001     Document Type: Article

References (59)

1. Characterization of a herpes simplex virus type 1 mutant which has a temperature-sensitive defect in penetration of cells and assembly of capsids
2. Herpes simplex virus type 1 UL28 gene product is important for the formation of mature capsids
3. Characterization of an essential HSV-1 protein encoded by the UL25 gene reported to be involved in virus penetration and capsid assembly
4. The herpes simplex virus UL33 gene product is required for the assembly of full capsids
5. The herpes simplex virus 1 UL15 gene encodes two proteins and is required for cleavage of genomic viral DNA
6. The open reading frames UL3, UL4, UL10, and UL16 are dispensable for the replication of herpes simplex virus 1 in cell culture
7. Initiation of P22 procapsid assembly in vivo
8. Purification and organization of the gene 1 portal protein required for phage P22 DNA packaging
9. DNA packaging in dsDNA bacteriophages
10. Liquid-crystalline, phage-like packing of encapsidated DNA in herpes simplex virus
11. Identification and genetic mapping of a herpes simplex virus capsid protein that binds DNA
12. Resolution of genotypic and phenotypic properties of herpes simplex virus type 1 temperature-sensitive mutant (KOS) tsZ47: Evidence for allelic complementation in the UL28 gene
13. Structural analysis of the capsid polypeptides of herpes simplex virus types 1 and 2
14. Mutations in herpes simplex virus type 1 genes encoding VP5 and VP23 abrogate capsid formation and cleavage of replicated DNA
15. The size and symmetry of B capsids of herpes simplex virus type 1 are determined by the gene products of the UL26 open reading frame
16. Proteins specified by herpes simplex virus. 8. Characterization and composition of multiple capsid forms of subtypes 1 and 2
17. Interaction of the bacteriophage phi 29 connector protein with the viral DNA
18. Conformational changes in bacteriophage φ 29 connector prevents DNA-binding activity
19. Mechanism of head assembly and DNA encapsulation in Salmonella phage P22. II. Morphogenetic pathway
20. The herpes simplex virus type 1 cleavage/packaging protein, UL32, is involved in efficient localization of capsids to replication compartments
21. The herpes simplex virus type 1 UL6 protein is essential for cleavage and packaging but not for genomic inversion
22. The herpes simplex virus 1 gene encoding a protease also contains within its coding domain the gene encoding the more abundant substrate
23. Characterization of enveloped tegument structures (L particles) produced by alphaherpesviruses: Integrity of the tegument does not depend on the presence of capsid or envelope
24. The product of the herpes simplex virus type 1 UL25 gene is required for encapsidation but not for cleavage of replicated viral DNA
25. The bacteriophage φ29 head-tail connector imaged at high resolution with the atomic force microscope in buffer solution
26. Bacteriophage lambda DNA maturation and packaging
27. Head morphogenesis of complex double-stranded deoxyribonucleic acid bacteriophages
28. Induced extrusion of DNA from the capsid of herpes simplex virus type 1
29. Structure of the herpes simplex virus capsid: Effects of extraction with guanidine hydrochloride and partial reconstitution of extracted capsids
30. Use of Ar+ plasma etching to localize structural proteins in the capsid of herpes simplex virus type 1
31. Assembly of the herpes simplex virus procapsid from purified components and identification of small complexes containing the major capsid and scaffolding proteins
32. Cell-free assembly of the herpes simplex virus capsid
33. Structure of the herpes simplex virus capsid. Molecular composition of the pentons and the triplexes
34. Localization of the herpes simplex virus type 1 major capsid protein VP5 to the cell nucleus requires the abundant scaffolding protein VP22a
35. The product of the UL6 gene of herpes simplex virus type 1 is associated with virus capsids
36. Isolation and characterization of herpes simplex virus type 1 mutants defective in the UL6 gene
37. Biochemical studies of the maturation of herpesvirus nucleocapsid species
38. Physical mapping and nucleotide sequence of a herpes simplex virus type 1 gene required for capsid assembly
39. Characterization of a temperature-sensitive mutant of the UL15 open reading frame of herpes simplex virus 1
40. Functions of two new genes in Salmonella phage P22 assembly
41. Identification and characterization of a herpes simplex virus gene product required for encapsidation of virus DNA
42. Assembly of bacteriophage P22: A model for ds-DNA virus assembly
43. Structure and assembly of herpesviruses
44. Multiple interactions control the intracellular localization of the herpes simplex virus type 1 capsid proteins
45. The products of herpes simplex virus type 1 gene UL26 which are involved in DNA packaging are strongly associated with empty but not with full capsids
46. The herpes simplex virus type 1 U(L)17 gene encodes virion tegument proteins that are required for cleavage and packaging of viral DNA
47. Temperature-sensitive mutants of herpes simplex virus type 1: Isolation, complementation and partial characterization
48. Three-dimensional structure of the HSV-1 nucleocapsid
49. Characterization of intranuclear capsids made by ts morphogenic mutants of HSV-1
50. Steps in the stabilization of newly packaged DNA during phage P22 morphogenesis
51. Assembly of a tailed bacterial virus and its genome release studied in three dimensions
52. Assembly of herpes simplex virus type 1 capsids using a panel of recombinant baculoviruses
53. Herpes simplex virus type 1 DNA cleavage and encapsidation require the product of the UL28 gene: Isolation and characterization of two UL28 deletion mutants
54. The herpes simplex virus procapsid: Structure, conformational changes upon maturation, and roles of the triplex proteins VP19c and VP23 in assembly
55. Herpes simplex virus DNA replication and genome maturation
56. Herpes simplex virus type 1 cleavage and packaging proteins UL15 and UL28 are associated with B but not C capsids during packaging
57. Visualization of tegument-capsid interactions and DNA in intact herpes simplex virus type 1 virions
58. Protein subunit structures in the herpes simplex virus A-capsid determined from 400-kV spot-scan electron cryomicroscopy