Chronic toxicity of chloroform to Japanese medaka fish

Environmental Health Perspectives

Volumn 109, Issue 1, 2001, Pages 35-40

  Toussaint, M W ^a   Rosencrance, A B ^a   Brennan, L M ^a   Beaman, J R ^a   Wolfe, M J ^a   Hoffmann, F J ^a   Gardner H S , Jr ^a  

^a SCIENCE APPLICATIONS INTERNATIONAL CORPORATION   (United States)

Author keywords

5 bromo 2 deoxyuridine; Aquatic toxicology; Carcinogenecity; Cell proliferation; Chloroform; Fish; Hematology; Histopathology; Medaka; Oryzias latipes

Indexed keywords

CHLOROFORM;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BILE DUCT DISEASE; BIOACCUMULATION; BLOOD CELL; BLOOD CELL COUNT; CELL PROLIFERATION; CELL VIABILITY; CHRONIC TOXICITY; CIRCULATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYPRINODONTIFORMES; EXPOSURE; FEMALE; GALLBLADDER DISEASE; GAS CHROMATOGRAPHY; HEMATOCRIT; HISTOPATHOLOGY; JAPAN; LIVER; LIVER CARCINOGENESIS; LIVER CELL; MALE; METABOLITE; NONHUMAN; PRIORITY JOURNAL;

ANIMALIA; CYPRINODONTIFORMES; LATIPES; ORYZIAS LATIPES;

EID: 0035147155     PISSN: 00916765     EISSN: None     Source Type: Journal    
DOI: 10.1289/ehp.0110935     Document Type: Article

References (43)

1. A Molecular approach to cancer
2. Chloroform mode of action: Implications for cancer risk assessment
3. Tests for predicting carcinogenicity in fish
4. Fish as model systems
5. Development of aquarium fish models for environmental carcinogenesis: An intermittent flow exposure system for volatile, hydrophobic chemicals
6. New methods for on-site biological monitoring of effluent water quality
7. The use of nontraditional assays in an integrated environmental assessment of contaminated ground water
8. Histologic and electron microscopy observations of diethylnitrosamine-induced hepatomas in small aquarium fish (Oryzias latipes)
9. Usefulness and rapidity of screening for the toxicity and carcinogenicity of chemicals in medaka, Oryzias latipes
10. Japanese medaka liver tumor model: Review of literature and new findings
11. Carcinogenicity tests with small fish species
12. Environmental complex mixture toxicity assessment
13. Carcinogenicity tests using aquarium fish
14. Guidelines for measuring chemically induced cell proliferation in specific rodent target organs
15. Dose response of hepatic and renal DNA synthetic rates to continuous exposure to bromodeoxyuridine (BrdU) via slow-release pellets or osmotic minipumps im male B6C3F1 mice
16. Evaluation of proliferating cell nuclear antigen (PCNA) as an endogenous marker of cell proliferation in rat liver: A dual stain comparison with 5-bromo-2′-deoxyuridine
17. A unique pattern of hepatocyte proliferation in F344 rats following long-term exposures to low levels of a chemical mixture of groundwater contaminants
18. A cell proliferation assay for small fish and aquatic invertebrates using bath exposure to bromodeoxyuridine
19. Elevated ornithine decarboxylase activity, polyamines and cell proliferation in neoplastic and vacuolated liver cells of winter flounder (Pleuronectes americanus)
20. Immunohistochemical detection of CCL4-induced, mitosis-related DNA synthesis in the livers of trout and rat
21. 3H]thymidine administered by injection or osmotic pump
22. Renal tubular cell regeneration, cell proliferation and chronic nephrotoxicity in the goldfish Carassius auratus following exposure to a single sublethal dose of dexachlorobutadiene
23. The killifish Nothobranchius rachowi, a new animal in genetic toxicology
24. An in vivo method for using 5-bromo-2′-deoxyuridine (BrdU) as a marker of chemically-induced hepatocellular proliferation in the Japanese medaka (Oryzias latipes)
25. Acute toxicity of four drinking water disinfection byproducts to juvenile Japanese medaka fish
26. Determination of trichlorethylene metabolites in rat liver homogenate using headspace chromatography
27. Automatic headspace gas chromatography for the simultaneous determination of trichloroethylene and metabolites in blood and urine
28. Histopathology of Japanese medaka (Oryzias latipes) chronically exposed to a complex environmental mixture
29. Comparison of chloroform-induced toxicity in the kidneys, liver, and nasal passages of male Osborne-Mendel and F-344 rats
30. Chloroform-induced cytotoxicity and regenerative cell proliferation in the kidneys and liver of BDF1 mice
31. A 90-day chloroform inhalation study in female and male B6C3F1 mice: Implications for cancer risk assessment
32. Differential toxicity of chloroform in the mouse
33. A non-bile duct origin for intestinal crypt-like ducts with periductular fibrosis induced in livers of F344 rats by chloroform inhalation
34. Relationship of hepatocarcinogenicity and hepatocellular proliferation induced by mutagenic noncarcinogens vs carcinogens
35. Relationship between hepatocyte necrosis, proliferation, and initiation induced by diethylnitrosamine in the male F344 rat
36. In vivo CHCL3 bioactivation, toxicokinetics, toxicity, and induced compensatory cell proliferation in B6C3F1 male mice
37. A method to quantitate the relative initiating and promoting potencies of hepatocarcinogenic agents in their dose-response relationships to altered hepatic foci