hprt mutant frequencies, nonpulmonary malignancies, and domestic radon exposure: "Postmortem" analysis of an interesting hypothesis

Environmental and Molecular Mutagenesis

Volumn 37, Issue 1, 2001, Pages 7-16

  Ruttenber, A James ^a   Harrison, L Tony ^b   Baron, Anna ^a   McClure, David ^a   Glanz, Jason ^a   Quillin, Robert ^b   O'Neill, J Patrick ^c   Sullivan, Linda ^c   Campbell, Jesse ^c   Nicklas, Janice A ^c  

^a UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^b Air Pollution Control Division   (United States)

^c UNIVERSITY OF VERMONT   (United States)

Author keywords

Biomarkers; Cancer; Epidemiology; hprt locus; Leukemia; Mutation; Radon

Indexed keywords

HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; RADON;

ADOLESCENT; ADULT; ARTICLE; CANCER; CANCER RISK; CHROMOSOME TRANSLOCATION; CLINICAL ARTICLE; CYTOGENETICS; FEMALE; GENE LOCUS; GENE MUTATION; HUMAN; LEUKEMIA; MALE; MOLECULAR CLONING; RADIATION DOSE; RADIATION EXPOSURE;

ADOLESCENT; BIOLOGICAL MARKERS; CAUSALITY; COLORADO; DATA INTERPRETATION, STATISTICAL; ENVIRONMENTAL EXPOSURE; FEMALE; HUMANS; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; LINEAR MODELS; MALE; MODELS, STATISTICAL; MUTATION; NEOPLASMS; RADON; RESEARCH DESIGN;

EID: 0035144257     PISSN: 08936692     EISSN: None     Source Type: Journal    
DOI: 10.1002/1098-2280(2001)37:1<7::AID-EM1001>3.0.CO;2-H     Document Type: Article

References (95)

1. Indoor radon exposure and cytogenetic damage
2. Indoor radon, an extrapulmonary genetic risk?
3. In vivo somatic mutations in humans: Measurement and analysis
4. In vivo mutations in human T-cells after ionizing radiation exposures
5. In vivo mutations in human blood cells: Biomarkers for molecular epidemiology
6. Radiation quality affects the efficiency of induction and the molecular spectrum of HPRT mutations in human T cells
7. Radon and leukaemia
8. Fat cells in red bone marrow of human rib: Their size and spatial distribution with respect to the radon-derived dose to the haematopoietic tissue
9. Molecular analysis of hypoxanthine phosphoribosyltransferase gene deletions induced by alpha- and X-radiation in human lymphoblastoid cells
10. Cytogenetic investigations in a Brazilian population living in an area of high natural radioactivity
11. Chromosome aberrations in peripheral lymphocytes from occupants of houses with elevated indoor radon concentrations
12. Quantification of FISH-painted chromosome aberrations after domestic radon exposure
13. Radon and leukaemia
14. Ionizing radiation
15. Measurement of HPRT mutant frequencies in T-lymphocytes from healthy human populations
16. Chromosome aberrations as a biological dose-response indicator of radiation exposure in uranium mines
17. Possible association between mutant frequency in peripheral lymphocytes and domestic radon concentrations
18. Characterization of multilocus lesions in human cells exposed to X radiation and radon
19. Somatic mutant frequency, mutation rates and mutational spectra in the human population in vivo
20. Human population monitoring, a further assessment of factors influencing measurements of thioguanine-resistant mutant frequency in circulating T-lymphocytes
21. HPRT somatic mutation data
22. Elevated hprt mutant frequency in circulating T-lymphocytes of xeroderma pigmentosum patients
23. Mutant frequencies in workers at the Sellafield Installation
24. Lack of evidence for an association between the frequency of mutants or translocations in circulating lymphocytes and exposure to radon gas in the home
25. Radiobiological aspects and radiation levels associated with the milling of monazite sand
26. Nature of mutation in the human hprt gene following in vivo exposure to ionizing radiation of cesium-137
27. Monitoring hprt mutant frequency over time in T-lymphocytes of people accidentally exposed to high doses of ionizing radiation
28. Radiation risk estimation in human populations: Lessons from the radiological accident in Brazil
29. Radon and prostate cancer
30. Determination of hrpt mutant frequencies in T-lymphocytes from a healthy pediatric population: Statistical comparison between newborn, children and adult mutant frequencies, cloning efficiency and age
31. Gene mutations with characteristic deletions in cord blood T lymphocytes associated with passive maternal exposure to tobacco smoke
32. Cancer risk and radon exposure
33. Adult myeloid leukaemia, geology, and domestic exposure to radon and γ radiation: A case control study in central Italy
34. Geographical distribution of birth places of children with cancer in the UK
35. Desk calculation of probabilities for the distribution of the sample correlation coefficient
36. Increased somatic cell mutant frequency in atomic bomb survivors
37. In vivo mutant T cell frequency in atomic bomb survivors carrying outlying values of chromosome aberration frequencies
38. 222Rn alpha dose to organs other than the lung
39. Radon as a causative factor in induction of myeloid leukemia and other cancers
40. The environment and disease: Association or causation?
41. Mutant frequency at the HPRT locus in peripheral blood T-lymphocytes of atomic bomb survivors
42. HPRT mutant frequency and aromatic DNA adduct level in nonsmoking and smoking lung cancer patients and population controls
43. Southern blot and polymerase chain reaction exon analysis of HPRT-mutations induced by radon and radon progeny
44. Induction of hprt mutations in mice after exposure to fission-spectrum neutrons or 60-Co gamma rays
45. Etude des aberrations chromosomiques chez les personnes chroniquement exposees aux radiations ionisantes, Ra 226, Rn 222
46. Dose-rate effects of neutrons and gamma-rays on the induction of mutation and oncogenic transformation in plateau-phase mouse m5S cells
47. Radiation induced chromosomal instability in human T-lymphocytes
48. Measurement of mutation frequency at the HPRT locus in peripheral lymphocytes. Is this a good method to evaluate a cancer risk in pediatric patients?
49. Radiation-induced genomic instability: Delayed mutagenic and cytogenetic effects of X rays and alpha particles
50. Case-control study of childhood acute lymphoblastic leukemia and residential radon exposure
51. Radon exposure and leukemia
52. In vivo mutant frequency rises among breast cancer patients after exposure to high doses of gamma-radiation
53. Radon and leukaemia
54. A study of the effects of exposure on cleanup workers at the Chernobyl nuclear reactor accident using multiple end points
55. Childhood leukaemia and natural radiation
56. Ionizing radiation signature mutations in human cell mutants induced by low-dose exposures
57. Molecular analysis of in vivo hprt mutations in human T lymphocytes. V. Effects of total body irradiation secondary to radioimmunoglobulin therapy (RIT)
58. In vivo ionizing irradiations produce deletions in the hprt gene of human T-lymphocytes
59. Molecular epidemiology and prevention of cancer
60. The dose-effect relationship of chromosome aberrations to γ- and γ-irradiation in a population subjected to an increased burden of natural radioactivity
61. Hypoxanthine-guanine phosphoribosyltransferase activity in normal and leukaemic lymphocytes
62. Dose to red bone marrow from natural radon and thoron exposure
63. Spatial variation of natural radiation and childhood leukaemia incidence in Great Britain
64. An analysis of in vivo hprt mutant frequency in circulating T-lymphocytes in the normal human population: A comparison of four datasets
65. Increased hprt mutant frequencies in Brazilian children accidentally exposed to ionizing radiation
66. Genotoxic effects of radiotherapy and chemotherapy on the circulating lymphocytes of breast cancer patients. III. Measurement of mutant frequency to 6-thioguanine resistance
67. Evaluation of mutant frequencies at the hprt and the T-cell receptor loci in pediatric cancer patients before treatment
68. HPRT-mutant frequency and lymphocyte characteristics of workers exposed to ionizing radiation on a sporadic basis: A comparison of two exposure indicators, job title and dose
69. Mutation rates at the glycophorin A and HPRT loci in uranium miners exposed to radon progeny
70. Spectrum of in vivo hprt mutations in T lymphocytes from atomic bomb survivors. I. Sequence alterations in cDNA
71. Epidemiological studies of cancer in populations near nuclear facilities
72. Exposure to atmospheric radon
73. Mutation induction in gamma-irradiated primary human bronchial epithelial cells and molecular analysis of the HPRT-mutants
74. Large deletions at the HPRT locus associated with the mutator phenotype in a Bloom's syndrome lymphoblastoid cell line
75. Molecular bases for hereditary cancer-prone diseases
76. Elevated frequencies of hypoxanthine phosphoribosyltransferase lymphocyte mutants are detected in Russian liquidators 6 to 10 years after exposure to radiation from the Chernobyl nuclear power plant accident
77. Radon in Devon and Cornwall and paediatric malignancies
78. Radon exposure and leukemia in adulthood
79. Molecular characterization of hprt mutants induced by low- and high-LET radiations in human cells
80. Radiation-induced genomic instability in haemopoietic cells
81. Oxidative DNA damage and cytogenetic effects in flight engineers exposed to cosmic radiation