Pharmacokinetics, safety, and antiviral effects of hypericin, a derivative of St. John's wort plant, in patients with chronic hepatitis C virus infection

Antimicrobial Agents and Chemotherapy

Volumn 45, Issue 2, 2001, Pages 517-524

  Jacobson, J M ^a   Feinman, L ^a   Liebes, L ^a   Ostrow, N ^a   Koslowski, V ^a   Tobia, A ^a   Cabana, B E ^a   Lee, D H ^a   Spritzler, J ^a   Prince, A M ^a  

^a MOUNT SINAI MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HYPERICIN; VIRUS RNA;

ADULT; ANTIVIRAL ACTIVITY; AREA UNDER THE CURVE; ARTICLE; CHRONIC HEPATITIS; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG HALF LIFE; DRUG SAFETY; FEMALE; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; HYPERICUM PERFORATUM; MALE; PHASE 1 CLINICAL TRIAL; PHOTOTOXICITY; PRIORITY JOURNAL;

ADOLESCENT; ADULT; ANTIVIRAL AGENTS; ASPARTATE AMINOTRANSFERASES; FEMALE; FOLLOW-UP STUDIES; HALF-LIFE; HEPACIVIRUS; HEPATITIS C, CHRONIC; HUMANS; MALE; MIDDLE AGED; PERYLENE; PHOTOSENSITIVITY DISORDERS; RNA, VIRAL;

EID: 0035143423     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.45.2.517-524.2001     Document Type: Article

References (33)

1. Hepatitis C virus infection in post-transfusion hepatitis - An analysis with first- and second-generation assays
2. Three different patterns of hepatitis C virus infection in chimpanzees
3. The natural history of community-acquired hepatitis C in the United States
4. Epidemiology of hepatitis C
5. Is St. Johns wort (Hypericum perforatum) an effective antidepressant?
6. Natural products derived from plants as potential drugs for the photodynamic destruction of tumor cells
7. A long-term study of hepatitis C virus replication in non-A, non-B hepatitis
8. Phase I studies of hypericin, the active compound in St. John's wort, as an antiretroviral agent in HIV-infected adults. AIDS Clinical Trials Group Protocols 150 and 258
9. Photodynamic effects of hypericin on lipid peroxidation and antioxidant status in melanoma cells
10. Inhibition of cellular growth and induction of apoptosis in pituitary adenoma cell lines by the protein kinase C inhibitor hypericin: Potential therapeutic application
11. The importance of light in the anti-HIV effect of hypericin
12. Single dose and steady state pharmacokinetics of hypericin and pseudohypericin
13. Intrahepatic cytotoxic T lymphocytes specific for hepatitis C virus in patients
14. Antiretroviral activity of synthetic hypericin and related analogies
15. Sustained virologic response to interferon alpha (IFN-α) in chronic hepatitis C is associated with long-term histologic improvement and lack of hepatic HCV RNA
16. Studies of the mechanisms of action of the antiretroviral agents hypericin and pseudohypericin
17. A common structural core in the internal ribosome entry sites of picornavirus, hepatitis C virus and pestivirus
18. Photodynamic inactivation of infectivity of human immunodeficiency virus and other enveloped viruses using hypericin and rose bengal
19. A method for the quantitation of hypericin, an antiviral agent, in biological fluids by high-performance liquid chromatography
20. Long-term histologic improvement and loss of detectable intrahepatic HCV RNA in patients with chronic hepatitis C and sustained response to interferon-alpha therapy
21. Effect of St. John's wort (Hypericum perforatum) on cytochrome P-450 2D6 and 3A4 activity in healthy volunteers
22. Therapeutic agents with dramatic antiretroviral activity and little toxicity at effective doses: Aromatic polycyclic diones hypericin and pseudohypericin
23. Inhibition of duck hepatitis B virus replication by hypericin
24. Evolutionary relationship of hepatitis C, pesti-, flavi-, plant viruses, and newly discovered GB hepatitis agents
25. Indinavir concentrations and St. Johns wort
26. Strategies for evaluation of enveloped virus inactivation in red cell concentrates using hypericin
27. Hepatitis C virus infection is associated with the development of hepatocellular carcinoma
28. Long-term mortality after transfusion-associated non-A, non-B hepatitis
29. Hepatitis C virus infection as a risk factor for hepatocellular carcinoma in patients with cirrhosis. A case-control study
30. Virucidal activity of hypericin against enveloped and non-enveloped DNA and RNA viruses
31. Clinical outcomes after transfusion-associated hepatitis C
32. Pharmaceutical quality of hypericum extracts
33. Hypericin-induced apoptosis of human malignant glioma cells is light-dependent, independent of bcl-2 expression, and does not require wild-type p53