Strategies for evaluation of enveloped virus inactivation in red cell concentrates using hypericin

Photochemistry and Photobiology

Volumn 71, Issue 2, 2000, Pages 188-195

  Prince, Alfred M ^a,f   Pascual, Donna ^a   Meruelo, Daniel ^b   Liebes, Leonard ^b   Mazur, Yehuda ^c   Dubovi, Edward ^d   Mandel, Mathilda ^e   Lavie, Gad ^b,e  

^a Lindsley F Kimball Res Institute   (United States)

^b NEW YORK UNIVERSITY MEDICAL CENTER   (United States)

^c WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^d Department of Obstetrics Gynecology   (United States)

^e SHEBA MEDICAL CENTER   (Israel)

^f NEW YORK BLOOD CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HYPERICIN; PHORBOL ESTER; PHOTOSENSITIZING AGENT; SERUM ALBUMIN;

ARTICLE; BLOOD; CATTLE DISEASE; CELL LINE; CONTROLLED STUDY; ERYTHROCYTE; ERYTHROCYTE CONCENTRATE; HEPATITIS C VIRUS; HUMAN IMMUNODEFICIENCY VIRUS; ILLUMINATION; LIGHT; NONHUMAN; PHOTODYNAMICS; PHOTOSENSITIZATION; PHOTOTOXICITY; PROVIRUS; VIRUS ENVELOPE; VIRUS INACTIVATION;

BOS TAURUS; BOVINAE; BOVINE VIRAL DIARRHEA VIRUS 1; HEPATITIS C VIRUS; HUMAN IMMUNODEFICIENCY VIRUS;

EID: 0034143198     PISSN: 00318655     EISSN: None     Source Type: Journal    
DOI: 10.1562/0031-8655(2000)0710188SFEOEV2.0.CO2     Document Type: Article

References (24)

1. Horowitz, B., A. M. Prince, J. Hamman and C. Watklevicz (1994) Viral safety of solvent/detergent-treated blood products. Blood Coagul. Fibrinol. 5(Suppl.), 21-28.
2. Lin, L., G. P. Wiesehahn, P. A. Morel and L. Corash (1989) Use of 8-methoxypsoralen and long wavelength ultraviolet radiation for decontamination of platelet concentrates. Blood 74, 517-25.
3. Horowitz, B., B. Williams, S. Rywkin, A. M. Prince, D. Pascual, N. Geacintov and J. Valinsky (1991) Inactivation of viruses in blood with aluminum phthalocyanine derivatives. Transfusion 31, 102-108.
4. Meruelo, D., G. Lavie and D. Lavie (1988) Therapeutic agents with dramatic antiretroviral activity and little toxicity at effective doses: aromatic polycyclic diones hypericin and pseudohypericin. Proc. Natl. Acad. Sci. USA 85, 5230-5324.
5. Lavie, G., F. Valentine, B. Levin, Y. Mazur, G. Gallo, D. Lavie, D. Weiner and D. Meruelo (1989) Studies of the mechanisms of action of the antiretroviral agents hypericin and pseudohypericin. Proc. Natl. Acad. Sci. USA 86, 5963-5967.
6. Degar, S., G. Lavie and D. Meruelo (1993) Photodynamic inactivation of radiation leukemia virus produced from hypericin treated cells. Virology 197, 796-800.
7. Lavie, G., Y. Mazur, D. Lavie, A. M. Prince, D. Pascual, L. Liebes, B. Levin and D. Meruelo (1995) Hypericin as an inactivator of infectious viruses in blood products. Transfusion 35, 392-400.
8. Tang, J., J. M. Colacino, S. H. Larsen and W. Spitzer (1990) Virucidal activity of hypericin against enveloped and non-enveloped DNA and RNA viruses. Antiviral Res. 13, 313-326.
9. Carpenter, S. and G. A. Kraus (1991) Photosensitization is required for inactivation of equine infectious anemia virus by hypericin. Photochem. Photobiol. 53, 169-74.
10. Hudson, J. B., L. Harris and G. H. N. Towers (1993) The importance of light in the anti-HIV effect of hypericin. Antiviral Res. 20, 173-178.
11. Ohba, K., M. Mizokami, J. Y. Lau, E. Orito, K. Ikeo and T. Gojobori (1996) Evolutionary relationship of hepatitis C, pest-, flavi-, plant viruses, and newly discovered GB hepatitis agents. FEBS Lett. 378, 232-234.
12. Le, S. Y., A. Siddiqui and J. V. Maizel,Jr. (1996) A common structural core in the internal ribosome entry sites of picornavirus, hepatitis C virus and pestivirus. Virus Genes 12, 135-147.
13. Lavie, G., C. Kaplinsky, A. Toren, I. Aizman, D. Meruelo, Y. Mazur and M. Mandel (1999) A photodynamic pathway to apoptosis and necrosis induced by dimethyl tetrahydroxy helianthrone and hypericin in leukemic cells. Possible relevance to photodynamic therapy. Br. J. Cancer 79, 423-432.
14. Margolis-Nunno, H., E. Ben-Hur, P. Gottlieb, R. Robinson, J. Oetjen and B. Horowitz (1996) Inactivation by phthalocyanine photosensitization of multiple forms of human immunodeficiency virus in red cell concentrates. Transfusion 36, 743-750.
15. Lavie, D., D. Freeman, H. Bock, J. Fleischer, K. Van Kranenburg, Y. Ittah, Y. Mazur, G. Lavie, L. Liebes and D. Meruelo (1990) Hypericin, a potential anti-ADS drug. In Trends in Medicinal Chemistry '90, pp. 321-327. Proceedings of the XIth International Symposium on Medicinal Chemistry, 2-7 September, Jerusalem, Israel.
16. Liebes, L., Y. Mazur, D. Freeman, D. Lavie, G. Lavie, N. Kudler, S. Mendoza, B. Levin, H. Hochster and D. Meruelo (1991) A method for the quantitation of hypericin, an antiviral agent, in biological fluids by high-performance liquid chromatography. Anal. Biochem. 195, 77-85.
17. Choo, Q. L., G. Kuo, A. J. Weiner, L. R. Overby, D. W. Bradley and M. Houghton (1989) Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome. Science 244, 359-362.
18. Tabor, E. and K. Kabayashi (1992) Hepatitis C virus, a causative infectious agent for non-A, non-B hepatitis: prevalence and structure - summary of a conference on hepatitis C virus as a causative of hepatocellular carcinoma. J. Natl. Cancer Inst. 84, 86-90.
19. Choo, Q. L., K. Richman, J. H. Han, K. Berger, C. Lee, C. Dong, C. Gallegos, D. Coit, A. Medina-Selby, P. Barr, A. J. Weiner, D. W. Bradley, G. Kuo and H. Houghton (1991) Genetic organization and diversity of the hepatitis C virus. Proc. Natl. Acad. Sci. USA 88, 2451-2455.
20. Brown, E. A., H. Zhang, L. H. Ping and M. Lemon (1992) Secondary structure of the 5′-nontranslated regions of hepatitis C virus and pestivirus genomic RNAs. Nucleic Acids Res. 20, 5041-5045.
21. Hadjur, C., A. Jeunet and P. Jardon (1994) Photosensitization by hypericin: ESR evidence for singlet oxygen and superoxide anion radicals formation in an in vitro model. J. Photochem. Photobiol. B Biol. 26, 67-74.
22. Peter, M., J. Nakagawa, M. Doree, J. C. Labbe and E. A. Nigg (1990) In vitro disassembly of the nuclear lamina and M phase-specific phosphorylation of lamins by cdc2 kinase. Cell 61, 591-602.
23. Thomas, C., R. S. MacGill, G. C. Miller and R. Pardini (1992) Photoactivation of hypericin generates singlet oxygen in mitochondria and inhibits succinoxidase. Photochem. Photobiol. 55, 47-53.
24. Diwu, Z. and J. W. Lown (1993) Photosensitization with anti-cancer agents 17. EPR studies of photodynamic action of hypericin: formation of semiquinone radical and activated oxygen species on illumination. Free Radicals Biol. & Med. 14, 209-215.