The nitroxide Tempol affords protection against ultraviolet radiation in a transgenic murine fibroblast culture model of cutaneous photoaging

Experimental Dermatology

Volumn 10, Issue 1, 2001, Pages 55-61

  Bernstein, E F ^a   Kong, S K ^a   Brown, D B ^a   Kwak, B C ^a   Takeuchi, T ^a   Gasparro, F P ^a   Uitto, J ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

Photoaging; Reactive oxygen species; Ultraviolet radiation

Indexed keywords

CHLORAMPHENICOL ACETYLTRANSFERASE; ELASTIN; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE; TEMPOL;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CUTANEOUS PARAMETERS; ENZYME ACTIVITY; FIBROBLAST CULTURE; IN VITRO STUDY; MODEL; MOUSE; NONHUMAN; RADIATION ABSORPTION; RADIATION INJURY; RADIATION PROTECTION; SPECTRUM; TRANSGENIC MOUSE; ULTRAVIOLET RADIATION;

ANIMALS; CELLS, CULTURED; CYCLIC N-OXIDES; ELASTIN; FIBROBLASTS; FREE RADICAL SCAVENGERS; MICE; MICE, TRANSGENIC; MODELS, BIOLOGICAL; RADIATION PROTECTION; RADIATION-PROTECTIVE AGENTS; SKIN; SKIN AGING; SPIN LABELS; SUPEROXIDE DISMUTASE; ULTRAVIOLET RAYS;

EID: 0035141834     PISSN: 09066705     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-0625.2001.100107.x     Document Type: Article

References (44)

1. Early destructive effects of sunlight on human skin
2. Skin aging and photoaging: An overview
3. Elastic fibres in normal and sun-damaged skin: An immunohistochemical study
4. Enhanced elastin and fibrillin gene expression in chronically photodamaged skin
5. Ultraviolet radiation activates the human elastin promoter in transgenic mice: A novel in vivo and in vitro model of cutaneous photoaging
6. Tissue-specific and developmentally regulated expression of human elastin promoter activity in transgenic mice
7. Evaluation of sunscreens with various sun protection factors in a new transgenic mouse model of cutaneous photoaging that measures elastin promoter activation
8. 8-Methoxypsoralen and ultraviolet A radiation activate the human elastin promoter in transgenic mice: In vivo and in vitro evidence for gene induction
9. Photoaging from an oxidative standpoint
10. Cumulative effects from repeated exposures to suberythemal doses of UVB and UVA in human skin
11. Role of reactive oxygen species and free radicals from melanins in photoinduced cutaneous inflammations
12. Photo-oxidative skin damage and antioxidants
13. DNA breaks caused by monochromatic 365 nm ultraviolet-A radiation of hydrogen peroxide and their repair in human epithelioid and xeroderma pigmentosum cells
14. Free radical formation in the skin following exposure to ultraviolet light
15. Effects of single-dose ultraviolet radiation on skin superoxide dismutase, catalase, and xanthine oxidase in hairless mice
16. Effects of chronic exposure ultraviolet-A including 2% ultraviolet-B on free radical reduction systems in hairless mice
17. Effect of reactive oxygen species on the elastin mRNA expression in cultured human dermal fibroblasts
18. Systemic protection by antioxidants against UVL-induce erythema
19. Protective effect of a topically applied anti-oxidant plus an anti-inflammatory agent against ultraviolet radiation-induced chronic skin damage in the hairless mouse
20. Ultraviolet light protection by several new compounds
21. Hydroxyl radical quenching agents protect against DNA breakage caused by both 365-nm UVA and by gamma radiation
22. Inhibition of oxygen-dependent radiation-induced damage by the nitroxide superoxide dismutase mimic, Tempol
23. Biologically active metal-independent superoxide dismutase mimics
24. Human exposure to ultraviolet radiation
25. Free radicals in human skin before and after exposure to light
26. Ultraviolet light-induced free radical formation in skin: An electron paramagnetic resonance study
27. EPR detection of free radicals in UV-irradiated skin: Mouse versus human
28. Increased generation of hydrogen peroxide possibly from mitochondrial respiratory chain after UVB irradiation of murine fibroblasts
29. Effects of ultraviolet A and antioxidant defense in cultured fibroblasts and keratinocytes
30. Cyclobutane-type pyrimidine dimers in polynucleotides
31. Induction of pyrimidine dimers in epidermal DNA of hairless mice by UVB: An action spectrum
32. Oxidative defense in cultured human skin fibroblasts and keratinocytes from sun-exposed and non-exposed skin
33. Human recombinant interleukin-1 beta up-regulates elastin gene expression in dermal fibroblasts. Evidence for transcriptional regulation in vitro and in vivo
34. Interleukin 10 up-regulates elastin gene expression in vivo and in vitro at the transcriptional level
35. Singlet oxygen may mediate the ultraviolet A-induced synthesis of interstitial collagenase
36. Time-dependent effect of chronic UV irradiation on superoxide dismutase and catalase activity in hairless mice skin
37. Time course of changes in antioxidant enzymes in human skin fibroblasts after UVA irradiation
38. A novel metal-free low molecular weight superoxide dismutase mimic
39. Tempol inhibits neutrophil and hydrogen peroxide-mediated DNA damage
40. Nitroxide SOD-mimics: Modes of action
41. Nitroxide radicals protect DNA from damage when illuminated in vitro in the presence of dibenzoylmethane and a common sunscreen ingredient
42. Photobiology 102: UV sources and dosimetry - The proper use and measurement of "photons as a reagent"
43. Common fluorescent sunlamps are an inappropriate substitute for sunlight