Reactive oxygen species mediate alpha-adrenergic receptor-stimulated hypertrophy in adult rat ventricular myocytes

Journal of Molecular and Cellular Cardiology

Volumn 33, Issue 1, 2001, Pages 131-139

  Amin, Jay K ^a,b   Xiao, Lei ^a,b   Pimental, David R ^a,b   Pagano, Patrick J ^a,b   Singh, Krishna ^a,b   Sawyer, Douglas B ^a,b   Colucci, Wilson S ^a,b  

^a BOSTON MEDICAL CENTER   (United States)

^b BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Hypertrophy; Myocyte; Reactive oxygen species; Superoxide dismutase; 1 adrenergic receptor

Indexed keywords

ALPHA 1 ADRENERGIC RECEPTOR; ATRIAL NATRIURETIC FACTOR; INOSITOL PHOSPHATE; MANGANESE SUPEROXIDE DISMUTASE; MESSENGER RNA; NORADRENALIN; PHORBOL 13 ACETATE 12 MYRISTATE; PRAZOSIN; PROPRANOLOL; REACTIVE OXYGEN METABOLITE;

ACTIN FILAMENT; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; HEART MUSCLE CELL; HEART VENTRICLE HYPERTROPHY; MALE; NEWBORN; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0035140827     PISSN: 00222828     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmcc.2000.1285     Document Type: Article

References (41)

1. Norepinephrine-stimulated hypertrophy of cultured rat myocardial cells is an alpha 1 adrenergic response
2. Alpha 1-adrenergic stimulation of cardiac gene transcription in neonatal rat myocardial cells. Effects on myosin light chain-2 gene expression
3. Alpha 1-adrenergic receptor stimulation of sarcomeric actin isogene transcription in hypertrophy of cultured rat heart muscle cells
4. Gq- and ras-dependent pathways mediate hypertrophy of neonatal rat ventricular myocytes following alpha 1-adrenergic stimulation
5. The MEKK-JNK pathway is stimulated by alpha1-adrenergic receptor and ras activation and is associated with in vitro and in vivo cardiac hypertrophy
6. Regulation of growth in the adult cardiomyocytes
7. Mitogenic signaling mediated by oxidants in Ras-transformed fibroblasts
8. Angiotensin II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells
9. Inhibitory effects of antioxidants on neonatal rat cardiac myocyte hypertrophy induced by tumor necrosis factor-alpha and angiotensin II
10. Inhibition of copper-zinc superoxide dismutase induces cell growth, hypertrophic phenotype, and apoptosis in neonatal rat cardiac myocytes in vitro
11. Norepinephrine stimulates apoptosis in adult rat ventricular myocytes by activation of the β-adrenergic pathway
12. Luminol and lucigenin as detectors for 02.-
13. Stable Mn(III) porphyrins mimic superoxide dismutase in vitro and substitute for it in vivo
14. A comparative study of EPR spin trapping and cytochrome c reduction techniques for the measurement of superoxide anions
15. Interleukin-1 beta modulates the growth and phenotype of neonatal rat cardiac myocytes
16. Redox regulation of manganese superoxide dismutase
17. Alpha 1-adrenergic receptor mRNA level is regulated by norepinephrine in rabbit aortic smooth muscle cells
18. Molecular cloning, expression and characterization of cDNA encoding a mouse alpha 1a-adrenoceptor
19. EUK-8, a synthetic superoxide dismutase and catalase mimetic, ameliorates acute lung injury in endotoxemic swine
20. Alpha 1-adrenergic stimulation induces cardiac tolerance to hypoxia via induction and activation of Mn-SOD
21. Activation of phospholipase C by alpha 1-adrenergic receptors is mediated by the alpha subunits of Gq family
22. Cardiac myocyte hypertrophy is associated with c-myc protooncogene expression
23. Transcriptional activation of the cardiac myosin light chain 2 and atrial natriuretic factor genes by protein kinase C in neonatal rat ventricular myocytes
24. The alpha-1A-adrenergic receptor subtype mediates biochemical, molecular, and morphologic features of cultured myocardial cell hypertrophy
25. Regulation of protein synthesis and degradation in adult ventricular cardiomyocytes
26. Stimulation of hypertrophy of cultured neonatal rat heart cells through an alpha 1-adrenergic receptor and induction of beating through an alpha 1- and beta 1-adrenergic receptor interaction. Evidence for independent regulation of growth and beating
27. Alpha- and beta-adrenergic stimulation of protein synthesis in cultured adult ventricular cardiomyocytes
28. Mitochondrial electron transport complex I is a potential source of oxygen free radicals in the failing myocardium
29. Myocardial oxidative stress in heart failure. "Oxygen wastage" revisited
30. Oxidant-induced DNA damage of target cells
31. Redox control of vascular smooth muscle proliferation
32. 2 for platelet-derived growth factor signal transduction
33. Regulation of reactive-oxygen-species generation in fibroblasts by Rac1
34. Adrenergic receptor stimulation of the mitogen-activated protein kinase cascade and cardiac hypertrophy
35. Stimulation of the p38 mitogen-activated protein kinase pathway in neonatal rat ventricular myocytes by the G protein-coupled receptor agonists, endothelin-1 and phenylephrine: A role in cardiac myocyte hypertrophy?
36. Alpha 1-adrenergic agonists precondition rabbit ischemic myocardium independent of adenosine by direct activation of protein kinase C
37. Stimulation of "stress-regulated" mitogen-activated protein kinases (stress-activated protein kinases/c-Jun N-terminal kinases and p38-mitogen-activated protein kinases) in perfused rat hearts by oxidative and other stresses
38. Stimulation of multiple mitogen-activated protein kinase sub-families by oxidative stress and phosphorylation of the small heat shock protein, HSP25/27, in neonatal ventricular myocytes
39. Mitogen-activated protein kinases are activated by oxidative stress and cytokines in neonatal rat ventricular myocytes
40. Selenocompounds induce a redox modulation of protein kinase C in the cell, compartmentally independent from cytosolic glutathione: Its role in inhibition of tumor promotion
41. Signaling pathways in reactive oxygen species-induced cardiomyocyte apoptosis