Targets of a protease inhibitor, KNI-272, in HIV-1-infected cells

Journal of Medical Virology

Volumn 63, Issue 3, 2001, Pages 203-209

  Goto, Toshiyuki ^a   Nakano, Takashi ^a   Kohno, Takehiro ^a   Morimatsu, Shinichi ^a   Morita, Chizuko ^b   Hong, Wu ^b   Kiso, Yoshiaki ^b   Nakai, Masuyo ^a   Sano, Kouichi ^b  

^a OSAKA MEDICAL COLLEGE   (Japan)

^b KYOTO PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Doughnut shaped immature particles; Electron microscopy; Human immunodeficiency virus type 1

Indexed keywords

GAG PROTEIN; KYNOSTATIN 272; PROTEIN P17; PROTEIN P55; UNCLASSIFIED DRUG; VIRUS DNA; VIRUS PROTEIN;

ARTICLE; CELL SHAPE; CONCENTRATION RESPONSE; CONTROLLED STUDY; ELECTRON MICROSCOPY; ENZYME INHIBITION; EXTRACELLULAR SPACE; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOFLUORESCENCE; POLYMERASE CHAIN REACTION; PROTEIN EXPRESSION; PROTEINASE INHIBITION; PROVIRUS; REVERSE TRANSCRIPTION; VIRUS CULTURE; VIRUS DETECTION; VIRUS EXPRESSION; VIRUS MORPHOLOGY; VIRUS MUTATION; VIRUS PARTICLE;

ANTI-HIV AGENTS; CD4-POSITIVE T-LYMPHOCYTES; CELL LINE; CELLS, CULTURED; HIV PROTEASE INHIBITORS; HIV-1; OLIGOPEPTIDES; PROTEIN BIOSYNTHESIS; VIRUS ASSEMBLY;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 0035140574     PISSN: 01466615     EISSN: None     Source Type: Journal    
DOI: 10.1002/1096-9071(200103)63:3<203::AID-JMV1001>3.0.CO;2-F     Document Type: Article

References (33)

1. An inhibitor of the protease blocks maturation of human and simian immunodeficiency viruses and spread of infection
2. HIV-1 proteinase is required for synthesis of pro-viral DNA
3. Isolation of a T-lymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome (AIDS)
4. Antiviral properties of Ro 31-8959 an inhibitor of human immunodeficiency virus (HIV) proteinase
5. Hydroxyethylene isostere inhibitors of human immunodeficiency virus-1 protease: Structure-activity analysis using enzyme kinetics X-ray crystallography, and infected T-cell assays
6. Projection structures of human immunodeficiency virus type 1 (HIV-1) observed with high resolution electron cryo-microscopy
7. The budding of defective human immunodeficiency virus type 1 (HIV-1) particles from cell clones persistently infected with HIV-1
8. The life-cycle of human immunodeficiency virus type 1
9. A controlled trial of two nucleoside analogues plus indinavir in persons with human immunodeficiency virus infection and CD4 cell counts of 200 per cubic millimeter or less
10. Removal of human immunodeficiency virus type 1 (HIV-1) protease inhibitors from preparations of immature HIV-1 virions does not result in an increase in infectivity or the appearance of mature morphology
11. Expression of human immunodeficiency virus type 1 (HIV-1) gag antigens on the surface of a cell line persistently infected with HIV-1 that highly expresses HIV-1 antigens
12. Progression of early steps of human immunodeficiency virus type 1 replication in the presence of an inhibitor of viral protease
13. In vitro anti-human immunodeficiency virus (HIV) activities of transition state mimetic HIV protease inhibitors containing allophenylnorstatine
14. Antiviral and pharmacekinetic properties of C2 symmetric inhibitors of the human immunodeficiency virus type 1 protease
15. Activity of purified biosynthetic proteinase of human immunodeficiency virus on natural substrates and synthetic peptides
16. Sensitive reverse transcriptase assay to detect and quantitate human immunodeficiency virus
17. A synthetic HIV-1 protease inhibitor with antiviral activity arrests HIV-like particle maturation
18. Inhibition of HIV-1 protease in infected T-lymphocytes by synthetic peptide analogues
19. Kynostatin (KNI)-227 and -272, highly potent anti-HIV agents: Conformationally constrained tripeptide inhibitors of HIV protease containing allophanylnorstatine
20. Rosette-forming human lymphoid cell lines. I. Establishment and evidence for origin of thymus-derived lymphocytes
21. Antiviral activity of human immunodeficiency virus type 1 protease inhibitors in a single cycle of infection: Evidence for a role of protease in the early phase
22. An improved non-radioisotopic reverse transcriptase assay and its evaluation
23. Three-dimensional structure of aspartyl protease from human immunodeficiency virus HIV-1
24. DNA amplification for direct detection of HIV-1 in DNA of peripheral blood mononuclear cells
25. Relative potency of protease inhibitors in monocytes/macrophages acutely and chronically infected with human immunodeficiency virus
26. Rational design of peptide-based HIV proteinase inhibitors
27. Enzymatic amplification of β-globin genomic sequences and restriction site analysis for diagnosis of sickle cell anemia
28. A unique monoclonal antibody that recognizes mature p17 of HIV-1 but not its precursor
29. Analysis of non-infectious HIV particles produced in presence of HIV proteinase inhibitor
30. Comparison of the HIV-1 and HIV-2 proteinases using oligopeptide substrates representing cleavage sites in Gag and Gag-Pol polyproteins
31. HIV-1 protease does not play a critical role in the early stages of HIV-1 infection
32. Nucleotide sequence of the AIDS virus, LAV
33. HIV-1 entry into quiescent primary lymphocytes: Molecular analysis reveals a labile, latent viral structure