Stability of morphine, morphine-3-glucuronide, and morphine-6-glucuronide in fresh blood and plasma and postmortem blood samples

Journal of Analytical Toxicology

Volumn 25, Issue 1, 2001, Pages 2-7

  Skopp, Gisela ^a   Pötsch, Lucia ^b   Klingmann, Andrea ^a   Mattern, Rainer ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

MORPHINE; MORPHINE 3 GLUCURONIDE; MORPHINE 6 GLUCURONIDE;

ARTICLE; AUTOPSY; BLOOD SAMPLING; DRUG DECOMPOSITION; DRUG DEGRADATION; DRUG DETERMINATION; DRUG ISOLATION; DRUG STABILITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; MASS SPECTROMETRY; NORMAL HUMAN; PHOTODEGRADATION; PLASMA; SOLID PHASE EXTRACTION; STORAGE;

EID: 0035140320     PISSN: 01464760     EISSN: None     Source Type: Journal    
DOI: 10.1093/jat/25.1.2     Document Type: Article

References (30)

1. Stability of phencyclidine in stored blood
2. 9-tetrahydrocannabinol (THC), 11-hydroxy-THC, and 11-nor-9-carboxy-THC in blood and plasma
3. Tetrahydrocannabinol stability in whole blood: Plastic versus glass container
4. Nachuntersuchungen an medikamentpositiven blutproben
5. A comprehensive study of the stability of cocaine and its metabolites
6. 9-tetrahydrocannabinol-9-carboxylic acid in whole blood using Abuscreen™ radioimmunoassay
7. Stability of drugs of abuse in biological specimens
8. Improved long-term stability of blood cocaine in evacuated collection tubes
9. A 5-year stability study of common illicit drugs in blood
10. Distribution of free and conjugated morphine in body fluids and tissues in a fatal heroin overdose: Is conjugated morphine stable in postmortem specimens?
11. A preliminary study on the stability of benzodiazepines in blood and plasma stored at 4°C
12. Stability of morphine and buprenorphine in whole blood
13. Morphine and morphine glucuronides in serum of heroin consumers and in heroin-related deaths determined by HPLC with native fluorescence
14. High performance liquid chromotographic determination of morphine and its 3- and 6-glucuronide metabolites: Improvements to the method and application to stability studies
15. High-performance liquid chromatographic-electrospray mass spectrometric determination of morphine and its 3- and 6-glucuronides: Application to pharmacokinetic studies
16. Determination of morphine, morphine-3-glucuronide and morphine-6-glucuronide in human serum by solid-phase extraction and liquid chromatography-mass spectrometry with electrospray ionisation
17. Determination of morphine and its 3- and 6-glucuronides, codeine, codeine-6-glucuronide and 6-monoacetylmorphine in body fluids by liquid chromatography athmospheric pressure chemical ionization mass spectrometry
18. Morphine, morphine-3-glucuronide, morphine-6-glucuronide, and 6-monoacetylmorphine determined by means of atmospheric pressure chemical ionization-mass spectrometry-liquid chromatography in body fluids of heroin victims
19. Simultaneous determination of heroin, 6-acetylmorphine, morphine, and its glucuronides by liquid chromatography-atmospheric pressure ionspray-mass spectrometry
20. High-performance liquid chromatography-mass spectrometry analysis of morphine and its application to a pharmacikinetic study in male Sprague-Dawley rats
21. Determination of morphine, morphine-3-glucuronide, and morphine-6-glucuronide in plasma after intravenous and inthrathecal morphine administration using HPLC with electrospray ionization and tandem mass spectrometry
22. The role of liquid chromatography-mass spectrometry in the determination of heroin and related opioids in biological fluids
23. Stabilität von alkaloiden in organischen lösungsmitteln. I
24. The structure of pseudomorphine
25. Stability of morphine in aqueous solutions III. Kinetics of morphine degradation in aqueous solution
26. Bacterial transmigration as an indicator of time of death
27. Postmortem drug metabolism by bacteria
28. Comparison of the hydrolysis rates of morphine-3-glucuronide and morphine-6-glucuronide with acid and β-glucuronidase