Induction of neutralizing antibodies against diphtheria toxin by priming with recombinant Mycobacterium bovis BCG expressing CRM197, a mutant diphtheria toxin

Infection and Immunity

Volumn 69, Issue 2, 2001, Pages 869-874

  Miyaji, E N ^a   Mazzantini, R P ^a   Dias, W O ^a   Nascimento, A L T O ^a   Marcovistz, R ^a   Matos, D S ^a   Raw, I ^a   Winter, N ^a   Gicquel, B ^a   Rappuoli, R ^a   Leite, L C C ^a  

^a INSTITUTO BUTANTAN   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

BCG VACCINE; CROSS REACTING ANTIGEN; DIPHTHERIA PERTUSSIS TETANUS VACCINE; DIPHTHERIA TOXIN; LIVE VACCINE; RECOMBINANT VACCINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIBODY PRODUCTION; ANTIBODY RESPONSE; ARTICLE; CONTROLLED STUDY; DIPHTHERIA; DRUG EFFECT; HUMORAL IMMUNITY; IMMUNE RESPONSE; IMMUNIZATION; MALE; MOUSE; MYCOBACTERIUM BOVIS; MYCOBACTERIUM FORTUITUM; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; SHUTTLE VECTOR; VERO CELL;

ANIMALS; ANTIBODIES, BACTERIAL; BACTERIAL PROTEINS; BCG VACCINE; DIPHTHERIA TOXIN; IMMUNIZATION; MALE; MICE; MICE, INBRED BALB C; VACCINES, SYNTHETIC;

EID: 0035140008     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.69.2.869-874.2001     Document Type: Article

References (30)

1. Recombinant BCG expressing the leishmania surface antigen Gp63 induces protective immunity against Leishmania major infection in BALB/c mice
2. Humoral and cellular immune responses in mice immunized with recombinant Mycobacterium bovis bacillus Calmette-Guérin producing a pertussis toxin-tetanus toxin hybrid protein
3. High-level expression of a proteolytically sensitive diphtheria toxin fragment in Escherichia coli
4. Effect of pH on the conformation of diphtheria toxin and its implications for membrane penetration
5. Protection of mice against tetanus challenge using an experimental tetanus vaccine based on recombinant BCG
6. Effective immunization against cutaneous leishmaniasis with recombinant bacille Calmette-Guérin expressing the Leishmania surface proteinase gp63
7. Recombinant Staphylococcus strains as live vectors for the induction of neutralizing anti-diphtheria toxin antisera
8. The amino-acid sequence of two non-toxic mutants of diphtheria toxin: CRM 45 and CRM 197
9. BCG as a vector for the construction of multivalent recombinant vaccines
10. Alternative method to remove antibacterial antibodies from antisera used for screening of expression libraries
11. Suitability of the Vero cell method for titration of diphtheria antitoxin in the United States potency test for diphtheria toxoid
12. 197) of diphtheria toxin in mice and guinea pigs and their implications on the development and control of diphtheria vaccine based on CRMs
13. Stable integration and expression of the Plasmodium falciparum circumsporozoite protein coding sequence in mycobacteria
14. Construction and murine immunogenicity of recombinant bacille Calmette Guérin vaccines expressing the B subunit of Escherichia coli heat labile enterotoxin
15. Haemophilus influenzae type b conjugate vaccines: A review of efficacy data
16. Vaccine production as a unit process
17. Immune responses induced by recombinant BCG strains according to level of production of a foreign antigen: MalE
18. Protective humoral response against pneumococcal infection in mice elicited by recombinant bacille Calmette-Guérin vaccines expressing pneumococcal surface protein A
19. Identification of Mycobacterium tuberculosis DNA sequences encoding exported proteins by using phoA gene fusions
20. pH dependence of the phospholipid interaction of diphtheria toxin fragments
21. Recombinant Mycobacterium boris BCG expressing pertussis toxin subunit S1 induces protection against an intracerebral challenge with live Bordetella pertussis in mice
22. 197, and its fragments in Salmonella typhi vaccine strain CVD 908-htrA
23. 197 differ in their interaction with lipids
24. Safety and immunogenicity of heptavalent pneumococcal vaccine conjugated to CRM197 in United States infants
25. New use of BCG for recombinant vaccines
26. Protective immunity elicited by recombinant bacille Calmette-Guérin (BCG) expressing outer surface protein A (OspA) lipoprotein: A candidate Lyme disease vaccine
27. Transcription and expression analysis, using lacZ and phoA gene fusions, of Mycobacterium fortuitum beta-lactamase genes cloned from a natural isolate and a high-level beta-lactamase producer
28. ADP-ribosylation of elongation factor 2 by diphtheria toxin
29. Expression of heterologons genes in Mycobacterium boris BCG: Induction of a cellular response against HIV-1 Nef protein
30. Recombinant BCG strains expressing the SIVmac251nef gene induce proliferative and CTL responses against nef synthetic peptides in mice