SADS: A new component of Fas-DISC is the accelerator for cell death signaling and is downregulated in patients with colon carcinoma

Nature Medicine

Volumn 7, Issue 1, 2001, Pages 88-93

  Suzuki, Atsushi ^a   Obata, Shigehiro ^b   Hayashida, Midori ^a   Kawano, Hirokazu ^a   Nakano, Takeshi ^c   Shiraki, Katsuya ^c  

^a DAIICHI SANKYO CO   (Japan)

^b Kishida Chemical Co Ltd   (Japan)

^c MIE UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 8; ENZYME PRECURSOR; FAS ANTIGEN; FAS ASSOCIATED DEATH DOMAIN PROTEIN; FAS DISC PROTEIN; FAS LIGAND; GENE PRODUCT; PROCASPASE 8; SADS PROTEIN; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; CELL DEATH; COLON CARCINOMA; COMPLEX FORMATION; CONTROLLED STUDY; ENZYME ACTIVITY; GENE DELETION; HUMAN; HUMAN CELL; HUMAN TISSUE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; SEQUENCE ANALYSIS; SIGNAL TRANSDUCTION;

ANTIGENS, CD95; APOPTOSIS; BASE SEQUENCE; CASPASE 8; CASPASE 9; CASPASES; COLONIC NEOPLASMS; DNA PRIMERS; DOWN-REGULATION; HUMANS; PROTEIN BINDING; SIGNAL TRANSDUCTION;

EID: 0035139017     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/83401     Document Type: Article

References (26)

1. Cell death: The significance of apoptosis
2. Apoptosis by death factor
3. The Fas death factor
4. A cell killing monoclonal antibody (anti-Fas) to a cell surface antigen co-downregulated with the receptor of tumor necrosis factor
5. Human ICE/CED-3 protease nomenclature
6. Sequential activation of ICE-like and CPP32-like proteases during Fas-mediated apoptosis
7. CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1β-converting enzyme
8. Involvement of MACH, a novel MORT-1/FADD-interacting protease, in Fas/APO-1 and TNF receptor-induced cell death
9. The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis
10. Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis
11. FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis
12. Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor
13. A combinatorial approach defines specifities of members of the caspase family and granzyme B: Functional relationships established for key mediators of apoptosis
14. Yama/CPP32β, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase
15. Studies of lamin proteinase reveal multiple parallel biochemical pathways during apoptosis
16. Acinus is a caspase-3-activated protein required for apoptotic chromatin condensation
17. DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis
18. Expression of Fas ligand in liver metastases of human colonic adenocarcinomas
19. FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death-inducing signaling complex
20. The CED-4-homologous protein FLASH is involved in Fas-mediated activation of caspase 8 during apoptosis
21. Functional absence of FADD in PLC/PRF/5 cells: Possible involvement in the transformation to hepatoma in HBV-infected hepatocyte
22. FADD/MORT1 and caspase-8 are recruited tO TRAIL receptor 1 and 2 are essential for apoptosis mediated by TRAIL receptor 2
23. Apo2L/TRAIL-dependent recuitment of endogenous FADD and caspase-8 to death receptors 4 and 5
24. Two CD95 (APO-1/Fas) signaling pathways
25. A novel protein domain required for apoptosis; Mutational analysis of human Fas
26. Involvement of CPP32/Yama(-like) proteases in Fas-mediated apoptosis