The partial nontandem duplication of the MLL (ALL1) gene is a novel rearrangement that generates three distinct fusion transcripts in B-cell acute lymphoblastic leukemia

Cancer Research

Volumn 61, Issue 1, 2001, Pages 59-63

  Whitman, Susan P ^a   Strout, Matthew P ^a   Marcucci, Guido ^a   Freud, Aharon G ^a   Culley, Lucia L ^a   Zeleznik Le, Nancy J ^c   Mrozek, Krzysztof ^b   Theil, Karl S ^a   Kees, Ursula R ^d   Bloomfield, Clara D ^b   Caligiuri, Michael A ^a,b  

^a Divisions of Hematology and Oncology ^*  (United States)

^b OHIO STATE UNIVERSITY   (United States)

^c LOYOLA UNIVERSITY CHICAGO   (United States)

^d UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

GENE PRODUCT;

ACUTE LYMPHOBLASTIC LEUKEMIA; ARTICLE; B CELL LEUKEMIA; CHIMERA; CHROMOSOME 11Q; CHROMOSOME 9P; CHROMOSOME ANALYSIS; CONTROLLED STUDY; FUSION GENE; GENE DUPLICATION; GENE EXPRESSION; GENE INSERTION; GENE REARRANGEMENT; GENE STRUCTURE; GENETIC DISORDER; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; LEUKEMOGENESIS; MOLECULAR MIMICRY; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL;

ALTERNATIVE SPLICING; BLOTTING, SOUTHERN; CHROMOSOME BREAKAGE; CHROMOSOMES, HUMAN, PAIR 11; CHROMOSOMES, HUMAN, PAIR 9; DNA-BINDING PROTEINS; EXONS; GENE REARRANGEMENT; HUMANS; LEUKEMIA, B-CELL, ACUTE; MYELOID-LYMPHOID LEUKEMIA PROTEIN; NUCLEAR PROTEINS; PROTO-ONCOGENES; RECOMBINANT FUSION PROTEINS; REPETITIVE SEQUENCES, NUCLEIC ACID; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TRANSCRIPTION FACTORS; TRANSLOCATION, GENETIC; TUMOR CELLS, CULTURED;

EID: 0035137703     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. MLL rearrangements in haematological malignancies: Lessons from clinical and biological studies
2. Identification of complex genomic breakpoint junctions in the t(9;11) MLL-AF9 fusion gene in acute leukemia
3. Partial tandem duplication of ALL1 as a recurrent molecular defect in acute myeloid leukemia with trisomy 11
4. Rearrangement of ALL1 (MLL) in acute myeloid leukemia with normal cytogenetics
5. Prognostic significance of partial tandem duplications of the MLL gene in acute myeloid leukemia with normal cytogenetics: A study within a multicenter treatment trial
6. Molecular rearrangement of the ALL-1 gene in acute myeloid leukemia without cytogenetic evidence of 11q23 chromosomal translocations
7. New translocation t(2;13)(p12;34) and rearrangement of the MLL gene in a childhood leukemia cell line
8. DNA structural properties of AF9 are similar to MLL and could act as recombination "hotspots" resulting in MLL-AF9 translocations and leukemogenesis
9. ALL-1 partial duplication in acute leukemia
10. Partial tandem duplications of the MLL gene are detectable in peripheral blood and bone marrow of nearly all healthy donors
11. Detection of unique ALL1 (MLL) fusion transcripts in normal human bone marrow and blood: Distinct origin of normal versu leukemic ALL1 fusion transcripts
12. Exon scrambling of MLL transcripts occur commonly and mimic partial genomic duplication of the gene
13. Real time quantitative PCR
14. The t(4;11) (q21;q23) chromosome translocations in acute leukemias involve the VDJ recombinase
15. Potential topoisomerase II DNA-binding sites at the breakpoints of a t(9;11) chromosome translocation in acute myeloid leukemia
16. Distribution of 11q23 breakpoints within the MLL breakpoint cluster region in de novo acute leukemia and in treatment-related acute myeloid leukemia: Correlation with scaffold attachment regions and topoisomerase II consensus binding sites
17. Genes on chromosomes 4, 9, and 19 involved in 11q23 abnormalities in acute leukemia share sequence homology and/or common motifs
18. A reverse transcriptase-polymerase chain reaction detects heterogeneous chimeric mRNAs in leukemias with 11q23 abnormalities
19. The MLL-AF9 gene fusion in mice controls myeloproliferation and specifies acute myeloid leukaemogenesis
20. Multiplex reverse transcription-polymerase chain reaction for simultaneous screening of 29 translocatons and chromosomal aberrations in acute leukemia
21. Association of chromosome arm 9p abnormalities with adverse risk in childhood acute lymphoblastic leukemia: A report from the Children's Cancer Group