Soluble substances released from postischemic reperfused rat hearts reduce calcium transient and contractility by blocking the L-type calcium channel

Journal of the American College of Cardiology

Volumn 37, Issue 2, 2001, Pages 668-675

  Felix, Stephan B ^a   Stangl, Verena ^b   Pietsch, Peter ^b   Bramlage, Peter ^b   Staudt, Alexander ^a   Bartel, Sabine ^c   Krause, Ernst Georg ^c   Borschke, Jörn Uwe ^d   Wernecke, Klaus Dieter ^e   Isenberg, Gerrit ^d   Baumann, Gert ^b  

^a UNIVERSITY OF GREIFSWALD   (Germany)

^b HUMBOLDT UNIVERSITY   (Germany)

^c MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^d MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

^e CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

1,4 DIHYDRO 2,6 DIMETHYL 5 NITRO 4 [2 (TRIFLUOROMETHYL)PHENYL] 3 PYRIDINECARBOXYLIC ACID METHYL ESTER; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; CALCIUM CHANNEL; CALCIUM CHANNEL BLOCKING AGENT; CALCIUM ION; CYCLIC AMP; CYCLIC GMP; CYCLIC GMP DEPENDENT PROTEIN KINASE; GLYCOGEN PHOSPHORYLASE; HEART MUSCLE DEPRESSANT FACTOR; ISOPRENALINE; PROTEIN KINASE C;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CALCIUM TRANSPORT; CHANNEL GATING; CONCENTRATION RESPONSE; CONTROLLED STUDY; FLUORESCENCE MICROSCOPY; HEART MUSCLE CONTRACTILITY; HEART MUSCLE ISCHEMIA; HEART MUSCLE REPERFUSION; INOTROPISM; NONHUMAN; PRIORITY JOURNAL; RAT; VOLTAGE CLAMP;

ANIMALS; CALCIUM; CALCIUM CHANNELS, L-TYPE; MYOCARDIAL CONTRACTION; MYOCARDIAL DEPRESSANT FACTOR; MYOCARDIAL REPERFUSION INJURY; PHOSPHORYLASES; RATS;

EID: 0035134687     PISSN: 07351097     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0735-1097(00)01132-3     Document Type: Article

References (36)

1. Release of a stable cardiodepressant mediator after myocardial ischaemia during reperfusion
2. Cardiodepressive mediators are released after ischemia from an isolated heart: Role of coronary endothelial cells
3. Excitation-contraction coupling
4. 2+) in mammalian ventricle: Dynamic control by cellular processes
5. 2+ release
6. Regulation of myocardial calcium channels by cyclic AMP metabolism
7. 2+ current is regulated by cyclic GMP-dependent protein kinase in mammalian cardiac myocytes
8. 2+, contraction, and potential in cardiac myocytes
9. Object-Image: An interactive image analysis program using structured point collection
10. Calcium currents of isolated bovine ventricular myocytes are fast and of large amplitude
11. Calcium tolerant ventricular myocytes prepared by preincubation in a 'KB medium'
12. A protein binding assay for adenosine 3′, 5′-cyclic monophosphate
13. Simultaneous isolation of adenosine 3′, 5′-cyclic monophosphate (cAMP) and guanosine 3′, 5′-cyclic monophosphate (cGMP) in small tissue samples
14. Femtomole-sensitive radioimmunoassay for cyclic AMP and cyclic GMP after 2′o-acetylation by acetic anhydride in aqueous solution
15. Use of a synthetic dodecapeptide (malantide) to measure the cyclic AMP-dependent protein kinase activity in a variety of tissues
16. Studies on a cyclic nucleotide-independent protein kinase and its proenzyme in mammalian tissues: I. Purification and characterization of an enzyme from bovine cerebellum
17. 1 receptor-independent activation of protein kinase C in acute myocardial ischemia: Mechanisms for sensitization of the adenylyl cyclase system
18. Correlation between contraction and phosphorylation of the inhibitory subunit of troponin in perfused rat heart
19. Protein measurement with folin phenol reagent
20. The action of calcium on cardiac phosphorylase b kinase
21. Control of phosphorylase activity in a muscle glycogen particle: Activation by calcium
22. In-vivo phosphorylation of the cardiac L-type calcium channel beta-subunit in response to catecholamines
23. Interaction between myocardial depressant factor and vasoactive mediators with ischemia and shock
24. 2+ current in cardiomyocytes
25. Effects of damaging the endocardial surface on the mechanical performance of isolated cardiac muscle
26. Endothelium, endocardium, and cardiac contraction
27. Cardiac endothelial cells modulate contractility of rat heart in response to oxygen tension and coronary flow
28. Novel cardiac myofilament desensitizing factor released by endocardial and vascular endothelial cells
29. 2+-independent inhibition of myocardial contraction by coronary effluent of hypoxic rat hearts
30. Inhibition of crossbridge function in the normal human heart by hypoxic endothelial superfusate
31. 2+ channels
32. Regional myocardial functional and electrophysiological alterations after brief coronary artery occlusion in conscious dogs
33. The stunned myocardium: Prolonged, postischemic ventricular dysfunction
34. Molecular and cellular mechanisms of myocardial stunning
35. Role of troponin I in the pathogenesis of stunned myocardium