Cytotoxic T-lymphocyte antigen-4 microsatellite polymorphism is associated with multiple myeloma

British Journal of Haematology

Volumn 112, Issue 1, 2001, Pages 216-218

  Zheng, Chengyun ^a   Huang, DeRen ^a   Liu, Li ^b   Björkholm, Magnus ^a   Holm, Göran ^a   Yi, Qing ^c   Sundblad, Anne ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b KAROLINSKA INSTITUTE   (Sweden)

^c UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

Author keywords

CTLA 4 gene; Multiple myeloma; Polymorphism

Indexed keywords

CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; MICROSATELLITE DNA;

ADULT; AGED; ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; EXON; FEMALE; GENE FREQUENCY; GENE LOCUS; GENETIC POLYMORPHISM; GENETIC SUSCEPTIBILITY; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; MONOCLONAL IMMUNOGLOBULINEMIA; MULTIPLE MYELOMA; PRIORITY JOURNAL;

ADULT; AGED; AGED, 80 AND OVER; ANTIGENS, CD; ANTIGENS, DIFFERENTIATION; CASE-CONTROL STUDIES; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; IMMUNOCONJUGATES; MALE; MICROSATELLITE REPEATS; MIDDLE AGED; MULTIPLE MYELOMA; PARAPROTEINEMIAS; POLYMORPHISM, GENETIC; PROBABILITY;

EID: 0035133158     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.2001.02552.x     Document Type: Article

References (12)

1. How B and T cells talk to each other
2. Multiple myeloma: Increasing evidence for a multistep transformation process
3. CTLA-4 and CD28 activated lymphocyte molecules are closely related in both mouse and human as to sequence, message expression, gene structure, and chromosomal location
4. T cells induce terminal differentiation of transformed B cells to mature plasma cell tumors
5. Dinucleotide repeat expansion in the CTLA-4 gene leads to T cell hyper-reactivity via the CD28 pathway in myasthenia gravis
6. Altered T cell repertoire usage in CD4 and CD8 subsets of multiple myeloma patients, a study of the Eastern Cooperative Oncology Group (E9487)
7. A CTLA-4 gene polymorphism is associated with both Graves disease and autoimmune hypothyroidism
8. CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation
9. The role of CTLA-4 in regulating Th2 differentiation
10. Dinucleotide repeat polymorphism at the human CTLA4 gene
11. A conserved AU sequence from the 3′ untranslated region of GM-CSF mRNA mediates selective mRNA degradation
12. Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4