Production of tumour necrosis factor-α by cultured human peripheral blood leucocytes in response to the anti-tumour agent 5,6-dimethylxanthenone-4-acetic acid (NSC 640488)

British Journal of Cancer

Volumn 76, Issue 12, 1997, Pages 1586-1591

  Philpott, M ^a   Joseph, W R ^a   Crosier, K E ^a   Baguley, B C ^a   Ching, L M ^a  

^a UNIVERSITY OF AUCKLAND   (New Zealand)

Author keywords

Clinical trial; Endotoxin; Flavone acetic acide; Tumour necrosis factor

Indexed keywords

5,6 DIMETHYLXANTHENONE; MITOFLAXONE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BLOOD SAMPLING; CELL CULTURE; CONTROLLED STUDY; HUMAN; HUMAN CELL; INCUBATION TIME; LEUKOCYTE; MESSENGER RNA SYNTHESIS; NORTHERN BLOTTING; PRIORITY JOURNAL; PROTEIN SYNTHESIS;

EID: 0030663473     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/bjc.1997.601     Document Type: Article

References (27)

1. Baguley BC, Calveley SB, Crowe KK, Fray LM, O'Rourke SA and Smith GP (1989) Comparison of the effects of flavone acetic acid, fostriecin, homoharringtonine and tumour necrosis factor alpha on Colon 38 tumors in mice. Eur J Cancer Clin Oncol 25: 263-269
2. Bendtzen K, Morling N, Fomsgaard A, Svenson M, Jacobsen B, Odum N and Svejgaard A (1988) Association between HLA-DR2 and production of tumour necrosis factor alpha and interleukin 1 by mononuclear cells activated by lipopolysaccharide. Scand J Immunol 28: 599-606
3. Bruin KF (1994) Endotoxin responsiveness in humans. PhD Dissertation. University of Amsterdam, The Netherlands
4. Carswell EA, Old LJ, Kassel RL, Green S, Fiore N and Williamson B (1975) An endotoxin-induced serum factor that causes necrosis of tumors. Proc Natl Acad Sci USA 25: 3666-3670
5. Ching L-M and Baguley BC (1987) Induction of natural killer cell activity by the antitumour compound flavone acetic acid (NSC 347512). Eur J Cancer Clin Oncol 23: 1047-1050
6. Ching LM, Joseph WR and Baguley BC (1993) Inhibition of antitumor effects of flavone acetic acid by cortisone. Anticancer Res 13: 1139-1141
7. Ching LM, Joseph WR, Crosier KE and Baguley BC (1994) Induction of tumor necrosis-factor-alpha messenger RNA in human and murine cells by the flavone acetic acid analogue 5,6-dimethylxanthenone-4-acetic acid (NSC 640488). Cancer Res 54: 870-872
8. Chomczynski P and Sacchi N (1987) Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162: 156-159
9. Drouet C, Shakhov AN and Jongeneel CV (1991) Enhancers and transcription factors controlling the inducibility of the tumor necrosis factor-alpha promoter in primary macrophages. J Immunol 147: 1694-1700
10. Finlay GJ, Smith GP, Fray LM and Baguley BC (1988) Effect of flavone acetic acid (NSC 347512) on Lewis lung carcinoma: evidence for an indirect effect. J Natl Cancer Inst 80: 241-245
11. Futami H, Eader LA, Komschlies KL, Bull R, Grays ME, Ortaldo JR, Young HL and Wiltrout RH (1991) Flavone acetic acid directly induces expression of cytokine genes in mouse splenic leukocytes but not in human peripheral blood leukocytes. Cancer Res 51: 6596-6602
12. Haziot A, Tsuberi BZ and Goyert SM (1993) Neutrophil CD14 - biochemical properties and role in the secretion of tumor necrosis factor-alpha in response to lipopolysaccharide. J Immunol 150: 5556-5565
13. Jacob CO, Fronek Z, Lewis GD, Koo M, Hansen JA and McDevitt HO (1990) Heritable major histocompatibility complex class II-associated differences in production of tumor necrosis factor alpha: relevance to genetic predisposition to systemic lupus erythematosus. Proc Natl Acad Sci USA 87: 1233-1237
14. Kerr DJ and Kaye SB (1989) Flavone acetic acid - preclinical and clinical activity. Eur J Cancer Clin Oncol 25: 1271-1272
15. Lee JD, Kato K, Tobias PS, Kirkland TN and Ulevitch RJ (1992) Transfection of CD14 into 70Z/3 cells dramatically enhances the sensitivity to complexes of lipopolysaccharide (LPS) and LPS binding protein. J Exp Med 175: 1697-1705
16. Mahadevan V, Malik STA, Meager A, Fiers W, Lewis GP and Hart IR (1990) Role of tumor necrosis factor in flavone acetic acid-induced tumor vasculature shutdown. Cancer Res 50: 5537-5542
17. Manus RM, Wilson AG, Mansfield J, Weir DG, Duff GW and Kelleher D (1996) TNF2, a polymorphism of the tumour necrosis-alpha gene promoter, is a component of the celiac disease major histocompatibility complex haplotype. Eur J Immunol 26: 2113-2118
18. McKeage MJ, Kestell P, Denny WA and Baguley BC (1991). Plasma pharmacokinetics of the antitumour agents 5,6-dimethylxanthenone-4-acetic acid, xanthenone-4-acetic acid and flavone-8-acetic acid in mice. Cancer Chemother Pharmacol 28: 409-413
19. Molvig J, Baek L, Christensen P, Manogue KR, Vlassara H, Platz P, Nielson LS, Svejgaard A and Nerup J (1988) Endotoxin-stimulated human monocyte secretion of interleukin 1, tumour necrosis factor alpha, and prostaglandin E2 shows stable interindividual differences. Scand J Immunol 27: 705-716
20. O'Dwyer PJ, Shoemaker D, Zaharko DS, Grieshaber C, Plowman J, Corbett T, Valeriote F, King SA, Cradock J, Hoth DF and Leyland-Jones B (1987) Flavone acetic acid (LM 975, NSC 347512), a novel antitumor agent. Cancer Chemother Pharmacol 19: 6-10
21. Perera PY, Barber SA, Ching LM and Vogel SN (1994) Activation of LPS-inducible genes by the antitumor agent 5,6-dimethylxanthenone-4-acetic acid in primary murine macrophages - dissection of signaling pathways leading to gene induction and tyrosine phosphorylation. J Immunol 153: 4684-4693
22. Philpott M, Baguley BC and Ching L-M (1995) Induction of tumour necrosis factor-alpha by single and repeated doses of the antitumour agent 5,6-dimethylxanthenone-4-acetic acid. Cancer Chemother Pharmacol 36: 143-148
23. Plowman J, Narayanan VL, Dykes D, Szarvasi E, Briet P, Yoder C and Paull KD (1986) Flavone acetic acid: a novel agent with preclinical antitumor activity against colon adenocarcinoma 38 in mice. Cancer Treat Rep 70: 631-638
24. Pratesi G, Rodolfo M, Rovetta G and Parmiani G (1990) Role of T cells and tumour necrosis factor in antitumour activity and toxicity of flavone acetic acid. Eur J Cancer 26: 1079-1083
25. Rewcastle GW, Kestell P, Baguley BC and Denny WA (1990) Light-induced breakdown of flavone acetic acid and xanthenone analogues in solution. J Natl Cancer Inst 82: 528-529
26. Rewcastle GW, Atwell GJ, Zhuang L, Baguley BC and Denny WA (1991) Potential antitumor agents. 61. Structure-activity relationships for in vivo colon-38 activity among disubstituted 9-oxo-9H-xanthene-4-acetic acids. J Med Chem 34: 217-222
27. Spies T, Morton CC, Nedospasov SA, Fiers W Pious D and Strominger JL (1986) Genes for the tumor necrosis factors alpha and beta are linked to the human major histocompatibility complex. Proc Natl Acad Sci USA 83: 8699-8702