L-lactate protects in vitro acetylcholinesterase (AChE) from inhibition by paraoxon (E 600)

Journal of Applied Toxicology

Volumn 20, Issue 4, 2000, Pages 249-257

  Petroianu, Georg ^a   Beha, Ulrike ^a   Roth, Christina ^a   Bergler, Wolfgang ^a   Rüfer, Roderich ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Acetylcholinesterase; In vitro; L lactate; Organophosphorus compounds; Paraoxon; Protection in poisoning

Indexed keywords

ACETYLCHOLINESTERASE; CHOLINESTERASE INHIBITOR; LACTIC ACID; PAROXYPROPIONE;

ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; HUMAN; HUMAN EXPERIMENT; INTOXICATION; MALE; NORMAL HUMAN; PLASMA; PRIORITY JOURNAL;

ACETYLCHOLINESTERASE; CHOLINESTERASE INHIBITORS; DRUG INTERACTIONS; FEMALE; HUMANS; HYDROGEN-ION CONCENTRATION; KINETICS; LACTIC ACID; MALE; PARAOXON; SUBSTRATE SPECIFICITY;

EID: 0033861444     PISSN: 0260437X     EISSN: None     Source Type: Journal    
DOI: 10.1002/1099-1263(200007/08)20:4<249::AID-JAT652>3.0.CO;2-X     Document Type: Article

References (19)

1. James JH, Luchette FA, McCarter FD and Fischer JE. Lactate is an unreliable indicator of tissue hypoxia in injury or sepsis. Lancet 1999; 354, 505-508.
2. Karalliedde L. Organophosphorus poisoning and anaesthesia, Anaesthesia 1999; 54, 1073-1088.
3. Levine R. Recognized and possible effects of pesticides in humans. In Handbook of Pesticide Toxicology. General Principles, ed. by W. J. Hayes and E. R. Laws, 1991; Vol. 1, pp. 275-360. Academic Press, San Diego.
4. Roth J. Nerve gases. Dtsch. Apoth. Ztg. 1991; 131, 313-315.
5. Schmidt G and Zech R. Organophosphate. Biochemie-Toxikologie-Therapie, Zivilschutzforschung, 1988; Vol. 22. Bundesamt für Zivilschutz (Hrsg.), Osang, Bonn.
6. Namba T, Nolte CT, Jackrel J and Grob D. Poisoning due to organophosphate insecticides: acute and chronic manifestations. Am. J. Med. 1971; 50, 475-492.
7. Zoch E. Die Wirkung organischer Phosphorsäureester bzw. Phosphorsäureester auf verschiedene Enzyme. Arzneim. Forsch. 1971; 21, 181-187.
8. Namba T. Cholinesterase inhibition by organophosphorus compounds, and its clinical effects. Bull. WHO 1971; 44, 289-307.
9. Petroianu G, Toomes LM, Petroianu A, Bergeler W and Rüfer R. Control of blood pressure, heart rate and haematocrit during high-dose intravenous paraoxon exposure in mini pigs. J. Appl. Toxicol. 1998; 18, 293-298.
10. Petroianu G, Kärcher B, Kern N, Hardt F, Helfrich U and Rüfer R. L-Lactate reduces in vitro the inhibition of butyrylcholinesterase (BChE) by paraoxon (E 600). J. Appl. Toxicol. 1999; 19, 329-336.
11. Halestrap AP, Wang X, Poole AC and Jackson VN. Lactate transport in relation to myocardial ischemia. Am. J. Cardiol. 1997; 80(3a), 17-25.
12. Skelton MS, Kremer DE, Smith EW and Gladden LB. Lactate influx into red blood cells from trained and untrained human subjects. Med. Sci. Sports Exercise 1998; 30, 536-542.
13. Lamanna JC, Harrington JF, Vendel LM, Abi-Saleh K, Lust WD and Harik SI. Regional blood-brain lactate influx. Brain Res. 1993; 614, 164-170.
14. Poole RC and Halestrap AP. Transport of lactate and other monocarboxylates across mammalian plasma-membranes. Am. J. Physiol. 1993; 264, c761-c782.
15. Baker SK, McCullagh KJA and Bonen A. Training intensity-dependent and tissue-specific increases in lactate uptake and MCT-1 in heart and muscle. J. Appl. Physiol. 1998; 84, 987-994.
16. Pellerin L, Pellegri G. Martin J-L and Magistretti P-J. Expression of monocarboxylate transports mRNAs in mouse brain: support for a distinct role of lactate as an energy substrate for the neonatal vs. adult brain. Proc. Natl. Acat. Sci. USA 1998; 95, 3990-3995.
17. Madias NE. Lactic acidosis. Kidney Int. 1986; 29, 725-774.
18. McCullagh KJA, Poole RC, Halestrap AP, O'Brian M and Bonen A. Role of the lactate transporter (MCT-1) in skeletal muscles. Am. J. Physiol. 1996; 271, E143-E150.
19. Drury DR and Wick AN. Chemistry and metabolism of L(+) and D(-) lactic acids. Ann. NY Acad. Sci. 1965; 119, 1061-1069.