Reduction of atherosclerosis despite hypercholesterolemia in lyn-deficient mice fed a high-fat diet

Genes to Cells

Volumn 6, Issue 1, 2001, Pages 37-42

  Miki, Shunji ^a   Horikawa, Keisuke ^b   Nishizumi, Hirofumi ^b   Suemura, Masaki ^a   Sato, Bunzo ^a   Yamamoto, Masahiro ^a   Takatsu, Kiyoshi ^b   Yamamoto, Tadashi ^b   Miki, Yoshitsugu ^c  

^a Nissei Hospital   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c Miki Clinic   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CD40 ANTIGEN; LOW DENSITY LIPOPROTEIN; MONOCYTE CHEMOTACTIC PROTEIN 1; PROTEIN TYROSINE KINASE; SCAVENGER RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATHEROGENESIS; ATHEROSCLEROSIS; CELL PROLIFERATION; CHEMICAL MODIFICATION; CONTROLLED STUDY; DIETARY INTAKE; FEMALE; HYPERCHOLESTEROLEMIA; LIPID BLOOD LEVEL; LIPID DIET; LIPID METABOLISM; MACROPHAGE; MALE; MOUSE; NONHUMAN; OXIDATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; STIMULATION;

ANIMALS; ARTERIOSCLEROSIS; CHO CELLS; CRICETINAE; DIETARY FATS; FEMALE; HYPERCHOLESTEROLEMIA; MACROPHAGES, PERITONEAL; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; SRC-FAMILY KINASES;

ANIMALIA;

EID: 0035131402     PISSN: 13569597     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2443.2001.00396.x     Document Type: Article

References (14)

1. -/- mice reveals a role for chemokines in initiation of atherosclerosis
2. Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery
3. Reduction of atherosclerosis in mice by inhibition of CD40 signaling
4. Functional and possible physical association of scavenger receptor with cytoplasmic tyrosine kinase Lyn in monocytic THP-1-derived macrophages
5. Impaired proliferation of peripheral B cells and indication of autoimmune disease in lyn-deficient mice
6. Increased autoantibody titers against epitopes of oxidized LDL in LDL receptor-deficient mice with increased atherosclerosis
7. Human apolipoprotein A-I gene expression increases high density lipoprotein and suppresses atherosclerosis in the apolipoprotein E-deficient mouse
8. Severe hypercholesterolemia and atherosclerosis in apolipoprotein E deficient mice created by homologous recombination in ES cells
9. Decreased atherosclerosis in mice deficient in both macrophage colony-stimulating factor (op) and apolipoprotein E
10. A role for macrophage scavenger receptors in atherosclerosis and susceptibility to infection
11. Effect of the antioxidant N,N′-diphenyl 1,4-phenylenediamine (DPPD) on atherosclerosis in apoE-deficient mice
12. Total cholesterol and risk of mortality in the oldest old
13. Induction of murine macrophage growth by modified LDLs
14. Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein E