Poly(adenosine diphosphate-ribose) synthetase inhibitor 3-aminobenzamide alleviates cochlear dysfunction induced by transient ischemia

Annals of Otology, Rhinology and Laryngology

Volumn 110, Issue 2, 2001, Pages 118-121

  Tabuchi, Keiji ^a   Ito, Zenya ^a   Tsuji, Shigeki ^a   Nakagawa, Akiko ^a   Serizawa, Fujiko ^a   Hara, Akira ^a   Kusakari, Jun ^a  

^a UNIVERSITY OF TSUKUBA   (Japan)

Author keywords

3 Aminobenzamide; Cochlea; Compound action potential; Ischemia; Poly(adenosine diphosphate ribose) synthetase

Indexed keywords

3 AMINOBENZAMIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE;

ACTION POTENTIAL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUDITORY THRESHOLD; CONTROLLED STUDY; DRUG EFFECT; EAR INJURY; ENDOLYMPH; GUINEA PIG; INNER EAR DISEASE; NONHUMAN; PRIORITY JOURNAL; REPERFUSION; TRANSIENT ISCHEMIC ATTACK;

ACTION POTENTIALS; ANALYSIS OF VARIANCE; ANIMALS; AUDITORY THRESHOLD; BENZAMIDES; BLOOD FLOW VELOCITY; COCHLEA; DISEASE MODELS, ANIMAL; DRUG EVALUATION, PRECLINICAL; GUINEA PIGS; POLY(ADP-RIBOSE) POLYMERASES; REPERFUSION INJURY; TIME FACTORS;

EID: 0035130206     PISSN: 00034894     EISSN: None     Source Type: Journal    
DOI: 10.1177/000348940111000205     Document Type: Article

References (20)

1. Hydrogen peroxide-induced injury of cells and its prevention by inhibitors of poly(ADP-ribose) polymerase
2. Mechanisms of oxidant-mediated cell injury
3. Nitric oxide activation of poly(ADP-ribose) synthetase in neurotoxicity
4. Inactivation of the poly(ADP-ribose) polymerase gene affects oxygen radical and nitric oxide toxicity in islet cells
5. Peroxynitrite and hydrogen peroxide induced cell death in the NSC34 neuroblastoma × spinal cord cell line: Role of poly(ADP-ribose) polymerase
6. DNA strand breakage, activation of poly(ADP-ribose) synthetase, and cellular energy depletion are involved in the cytotoxicity in macrophages and smooth muscle cells exposed to peroxynitrite
7. The protective effects of allopurinol and superoxide dismutasepolyethylene glycol on ischemic and reperfusion-induced cochlear damage
8. The effect of mannitol upon cochlear dysfunction induced by transient local anoxia
9. Effect of nitric oxide synthase inhibitor on cochlear dysfunction induced by transient local anoxia
10. Effect of 7-nitroindazole upon cochlear dysfunction induced by transient local anoxia
11. The effect of transient anoxia upon the cochlear potentials
12. Quantitative studies of inhibitors of ADP-ribosylation in vitro and in vivo
13. Inhibition of the activity of poly(ADP-ribose) synthetase reduces ischemia-reperfusion injury in the heart and skeletal muscle
14. Poly(ADPribose) polymerase gene disruption renders mice resistant to cerebral ischemia
15. Role of poly(ADP-ribose) formation in DNA repair
16. +-dependent repair of damaged DNA by human cell extracts
17. ADP-ribosylation in mammalian cell ghosts
18. Possible involvement of poly(ADP-rihosyl) polymerase in triggering stress-induced apoptosis
19. Mice lacking ADPRT and poly(ADP-ribosyl)ation develop normally but are susceptible to skin disease
20. Apoptosis in the absence of poly-(ADP-ribose) polymerase