Randomised controlled study of clinical efficacy of spacer therapy in asthma with regard to electrostatic charge

Archives of Disease in Childhood

Volumn 84, Issue 2, 2001, Pages 178-182

  Dompeling, E ^a   Oudesluys Murphy, A M ^b   Janssens, H M ^c   Hop, W ^d   Brinkman, J G ^b   Sukhai, R N ^e   De Jongste, J C ^c  

^a MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

^b Medisch Centrum Rijnmond Zuid   (Netherlands)

^c SOPHIA CHILDREN S HOSPITAL   (Netherlands)

^d ERASMUS UNIVERSITY ROTTERDAM   (Netherlands)

^e LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Asthma; Electrostatic charge; Salbutamol; Spacer

Indexed keywords

SALBUTAMOL;

ARTICLE; ASTHMA; BRONCHODILATATION; CHILD; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG EFFICACY; ELECTRICITY; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; METERED DOSE INHALER; NEBULIZER; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RESPIRATORY TRACT DISEASE;

ADMINISTRATION, INHALATION; ALBUTEROL; ANALYSIS OF VARIANCE; ASTHMA; BRONCHODILATOR AGENTS; CHILD; CHILD, PRESCHOOL; CROSS-OVER STUDIES; ELECTROSTATICS; EQUIPMENT DESIGN; FEMALE; HUMANS; MALE; METALS; NEBULIZERS AND VAPORIZERS; PEAK EXPIRATORY FLOW RATE; PLASTICS; TREATMENT OUTCOME;

EID: 0035129329     PISSN: 00039888     EISSN: 14682044     Source Type: Journal    
DOI: 10.1136/adc.84.2.178     Document Type: Article

References (27)

1. Aerosol treatment of young children
2. Use of budesonide in severe asthmatics aged 1-3 years
3. Pharmacological treatment in acute exacerbations of COPD
4. Bronchodilator delivery by metered-dose inhaler in ventilator supported patients
5. A metal aerosol holding chamber devised for young children with asthma
6. A non-electrostatic spacer for aerosol delivery
7. Effect of electrostatic charge, flow, delay and multiple actuations on the in vitro delivery of salbutamol from different small volume spacers for infants
8. Salbutamol delivery from a hydrofluoroalkane pressurized metered-dose inhaler in pediatric ventilatory circuits
9. Improvement in sodium cromoglycate delivery from a spacer device by use of an antistatic lining, immediate inhalation, and avoiding multiple actuations of drug
10. The effects of static charge in spacer devices on glucocorticosteroid aerosol deposition in asthmatic patients
11. The effect of delay, multiple actuations and spacer static charge on the in vitro delivery of budesonide from the Nebuhaler
12. Eleven peak flow meters: A clinical evaluation
13. Standardized lung function testing
14. The functional development of the respiratory system
15. Washing plastic spacers in household detergent reduces electrostatic charge and greatly improves delivery
16. 1
17. Deposition pattern of radiolabeled salbutamol inhaled from a metered-dose inhaler by means of a spacer with mask in young children with airway obstruction
18. Inhalational drug delivery from seven different spacer devices
19. High-percentage lung delivery in children from detergent-treated spacers
20. Drug delivery from holding chambers with attached facemask
21. Evaluation of inhalation aids of metered dose inhalers in asthmatic children
22. A trial of metaproterenol by metered-dose inhaler and two spacers in preschool asthmatics
23. Comparison of terbutaline via the Nebuhaler and salbutamol via the Volumatic: Theory and practice
24. Early lung absorption profile of non-CFC salbutamol via small and large volume plastic spacer devices
25. Relative bioavailability of salbutamol to the lung following inhalation using metered dose inhalation methods and spacer devices