Phosphodiesterase 3 as a potential target for therapy of malignant tumors in the submandibular gland

Anti-Cancer Drugs

Volumn 12, Issue 1, 2001, Pages 79-83

  Murata, T ^a   Sugatani, T ^a   Shimizu, K ^a   Manganiello, V C ^a   Tagawa, T ^a  

^a MIE UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Phosphodiesterase; Phosphodiesterase inhibitor; Salivary gland tumor

Indexed keywords

CILOSTAMIDE; MESSENGER RNA; PHOSPHODIESTERASE; PHOSPHODIESTERASE 3A; PHOSPHODIESTERASE 3B; PHOSPHODIESTERASE III; PHOSPHODIESTERASE INHIBITOR; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER GROWTH; CELL FREE SYSTEM; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; GROWTH INHIBITION; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SALIVARY GLAND CARCINOMA; SUPERNATANT;

3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE; CELL DIVISION; CYCLIC GMP; HUMANS; PHOSPHODIESTERASE INHIBITORS; QUINOLONES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; ROLIPRAM; SUBMANDIBULAR GLAND NEOPLASMS; TUMOR CELLS, CULTURED;

EID: 0035128927     PISSN: 09594973     EISSN: None     Source Type: Journal    
DOI: 10.1097/00001813-200101000-00011     Document Type: Article

References (33)

1. Perspectives in biochemistry and biophysics. Diversity in cyclic nucleotide phosphodiesterase isoenzyme families
2. Type III cGMP-inhibited cyclic nucleotide phosphodiesterases (PDE3 gene family)
3. Structure, localization, and regulation of cGMP-inhibited phosphodiesterase (PDE3)
4. Molecular cloning and expression of human myocardial cGMP-inhibited cAMP phosphodiesterase
5. Molecular cloning of the rat adipocyte hormone-sensitive cyclic GMP-inhibited cyclic nucleotide phosphodiesterase
6. Isolation and characterization of PDE8A, a novel human cAMP-specific phosphodiesterase
7. Molecular cloning and characterization of human PDE8B, a novel thyroid-specific isozyme of 3′,5′-cyclic nucleotide phosphodiesterase
8. Cloning and characterization of a cAMP-specific cyclic nucleotide phosphodiesterase
9. Isolation and characterization of PDE9A, a novel human cGMP-specific phosphodiesterase
10. Cloning and characterization of a novel human phosphodiesterase that hydrolyzes both cAMP and cGMP (PDE10A)
11. Molecular cloning and characterization of a distinct human phosphodiesterase gene family: PDE11A
12. Characterization of the cDNA and gene encoding human PDE3B, the cGIP1 isoform of the human cyclic GMP-inhibited cyclic nucleotide phosphodiesterase family
13. Differential expression of cyclic nucleotide phosphodiesterase 3 and 4 activities in human T cell clones specific for myelin basic protein
14. Induction of phosphodiesterses 3B, 4A4, 4D1, 4D2, and 4D3 in Jurkat T-cells and in human peripheral blood T-lymphocytes by 8-bromo-cAMP and Gs-coupled receptor agonists
15. Human platelet cGI-PDE: Expression in yeast and localization of the catalytic domain by deletion mutagenesis
16. Differential expression of cGMP-inhibited cyclic nucleotide phosphodiesterases in human hepatoma cell lines
17. A clinical approach to malignant tumours
18. A neoplastic epithelial duct cell line established from an irradiated human salivary gland
19. Single-step affinity purification, partial structure and properties of human platelet cGMP inhibited cAMP phosphodiesterase
20. Purification and characterization of a human platelet cyclic nucleotide phosphodiesterase
21. Purification of the putative hormone-sensitive cyclic AMP phosphodiesterase from rat adipose tissue using a derivative of cilostamide as a novel affinity ligand
22. The insulin- and glucagon-stimulated 'dense-vesicle' high-affinity cyclic AMP phosphodiesterase from rat liver. Purification, characterization and inhibitor sensitivity
23. Purification of an insulin-sensitive cyclic AMP phosphodiesterase from rat liver
24. Isolation and characterization of bovine cardiac muscle cGMP-inhibited phosphodiesterase: A receptor for new cardiotonic drugs
25. Characterization of two recombinant PDE3 (cGMP-inhibited cyclic nucleotide phosphodiesterase) isoforms, RcGIP1 and HcGIP2, expressed in NIH 3006 murine fibroblasts and Sf9 insect cells
26. Functions of the N-terminal region of cyclic nucleotide phosphodiesterase 3 (PDE3) isoforms
27. Distinctive anatomical patterns of gene expression for cGMP-inhibited cyclic nucleotide phosphodiesterases
28. Modulaton of rat thymocyte proliferative response through the inhibition of different cyclic nucleotide phosphodiesterase isoforms by means of selective inhibitors and cGMP-elevating agents
29. Synergistic interactions between selective pharmacological inhibitors of phosphodiesterase isozyme families PDE III and PDE IV to attenuate proliferation of rat vascular smooth muscle cells
30. 3prime;,5′-Cyclic nucleotide phosphodiesterase in tumor cells as potential target for tumor growth inhibition
31. Requirements for and kinetics of growth arrest of neoplastic cells by confluent 10T1/2 fibroblasts induced by a specific inhibitor of cyclic adenosine 3′:5′-phosphodiesterase
32. Direct effects of the pyrimido-pyrimidine derivative RA 233 (Rapenton) on rat 13762NF mammary tumor cell clones in vitro
33. Modulation of intracellular cyclic adenosine monophosphate levels and the differentiation response of human neuroblastoma cells