Dichloroacetate treatment for severe refractory metabolic acidosis during neonatal sepsis

Pediatric Infectious Disease Journal

Volumn 20, Issue 2, 2001, Pages 218-219

  Arnon, Shmuel ^a,b   Litmanovits, Ita ^a,b   Regev, Rivka ^a,b   Elpeleg, Orly ^c   Dolfin, Tzipora ^a,b  

^a MEIR MEDICAL CENTER   (Israel)

^b TEL AVIV UNIVERSITY   (Israel)

^c SHAARE ZEDEK MEDICAL CENTER   (Israel)

Author keywords

Acidosis; Dichloroacetate; Neonatal sepsis

Indexed keywords

AMPICILLIN; BICARBONATE; DICHLOROACETIC ACID;

ARTICLE; BACTERIAL MENINGITIS; CASE REPORT; CLINICAL FEATURE; DISEASE COURSE; DRUG MECHANISM; DRUG TOLERANCE; HUMAN; METABOLIC ACIDOSIS; NEWBORN; NEWBORN SEPSIS; PREMATURITY; PRIORITY JOURNAL; STREPTOCOCCUS AGALACTIAE;

ACIDOSIS, LACTIC; DICHLOROACETATE; HUMANS; INFANT, NEWBORN; SEPSIS; SODIUM BICARBONATE; STREPTOCOCCAL INFECTIONS;

EID: 0035128566     PISSN: 08913668     EISSN: None     Source Type: Journal    
DOI: 10.1097/00006454-200102000-00021     Document Type: Article

References (4)

1. Treatment of congenital lactic acidosis with dichloroacetate
2. Lactic acidosis and hypoglycaemia in children with severe malaria: Pathophysiological and prognostic significance
3. Lactic acidosis during sepsis is related to increased pyruvate production, not deficits in tissue oxygen availability
4. A controlled clinical trial of dichloroacetate for treatment of lactic acidosis in adults. The Dichloroacetate-Lactic Acidosis Study Group