Dietary effects of ortho-phenylphenol and sodium ortho-phenylphenate on rat urothelium

Toxicological Sciences

Volumn 59, Issue 2, 2001, Pages 346-351

  St John, M K ^a   Arnold, L L ^a   Anderson, T ^a   Cano, M ^a   Johansson, S L ^a   Cohen, S M ^a  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

Ortho phenylphenol; Rats; Sodium ortho phenylphenate; Urothelial effects

Indexed keywords

2 HYDROXYBIPHENYL; ASCORBIC ACID; BROXURIDINE; CALCIUM; MINERAL; PESTICIDE; PHENOL DERIVATIVE; SACCHARIN; SODIUM CHLORIDE; SODIUM DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL FOOD; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLADDER CARCINOGENESIS; BLADDER EPITHELIUM; BLADDER TUMOR; CELL PROLIFERATION; CONTROLLED STUDY; CRYSTALLIZATION; DIET; DIETARY INTAKE; DNA ADDUCT; FOOD INDUSTRY; HYPERPLASIA; LABELING INDEX; MALE; MICROSCOPY; NONHUMAN; PRECIPITATION; RAT; SCANNING ELECTRON MICROSCOPY; STONE FORMATION; TOXICITY TESTING; URINALYSIS; URINARY EXCRETION; URINE PH; UROTHELIUM;

ANIMALS; BIPHENYL COMPOUNDS; BODY WEIGHT; DIET; DRINKING; EATING; FUNGICIDES, INDUSTRIAL; HYDROGEN-ION CONCENTRATION; MALE; MICROSCOPY, ELECTRON, SCANNING; RATS; RATS, INBRED F344; URINALYSIS; URINARY BLADDER; UROTHELIUM;

ANIMALIA;

EID: 0035127508     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/59.2.346     Document Type: Article

References (40)

1. Comparative metabolism of ortho-phenylphenol in mouse, rat and man
2. Pathology of experimental bladder cancer in rodents
3. Urinary bladder carcinogenesis
4. Calcium phosphate-containing urinary precipitate in rat urinary bladder carcinogenesis. International Agency for Research on Cancer
5. Calcium phosphate-containing precipitate and the carcinogenicity of sodium salts in rats
6. Extensive handling of rats leads to mild urinary bladder hyperplasia
7. Urinary and urothelial effects of sodium salts in male rats
8. Comparative bladder tumor promoting activity of sodium saccharin, sodium ascorbate, related acids, and calcium salts in rats
9. Comparative analysis of the proliferative response of the rat urinary bladder to sodium saccharin by light and scanning electron microscopy and autoradiography
10. Effects of sodium ascorbate, sodium saccharin and ammonium chloride on the male rat urinary bladder
11. Multiple range and multiple F tests
12. Effect of sodium saccharin and calcium saccharin on urinary parameters in rats fed Prolab 3200 or AIN-76 diet
13. Inhibition of prostaglandin-H-synthase by o-phenylphenol and its metabolites
14. Effects of pH on the carcinogenicity of o-phenylphenol and sodium o-phenylphenate in the rat urinary bladder
15. 3 on o-phenylphenol-induced rat bladder carcinogenesis
16. Pathological analysis of the carcinogenicity of sodium o-phenylphenate and o-phenylphenol
17. Promoting effect of sodium o-phenylphenate and o-phenylphenol on two-stage urinary bladder carcinogenesis in rats
18. 1 mice
19. Sex differences in o-phenylphenol and sodium o-phenylphenate rat urinary bladder carcinogenesis: Urinary metabolites and electrolytes under conditions of aciduria and alkalinuria
20. Species differences in sodium o-phenylphenate induction of urinary bladder lesions
21. Induction of tumours of the urinary system in F344 rats by dietary administration of sodium o-phenylphenate
22. Induction of tumours of the urinary bladder in F344 rats by dietary administration of o-phenylphenol
23. Metabolism of phenylhydroquinone by prostaglandin (H) synthase: Possible implications in o-phenylphenol carcinogenesis
24. Effects of pH on nonenzymatic oxidation of phenylhydroquinone: Potential role in urinary bladder carcinogenesis induced by o-phenylphenol in Fischer F344 rats
25. Dose-dependent binding of ortho-phenylphenol to protein but not DNA in the urinary bladder of male F344 rats
26. Renal mineralization - A ubiquitous lesion in chronic rat studies
27. Randomization of animals by computer program for toxicity studies
28. 2-Amino-2-methyl-1-propanol as the alkalizing agent in an improved continuous-flow cresophthalein complexone procedure for calcium in serum
29. Oxidative damage to cellular and isolated DNA by metabolites of fungicide ortho-phenylphenol
30. DNA cleavage by phenylhydroquinone: The major metabolite of a fungicide o-phenylphenol
31. 32P-postlabeling technique
32. In vivo genotoxicity of sodium ortho-phenylphenol: Phenylbenzoquinone is one of the DNA-binding metabolite(s) of sodium ortho-phenylphenol
33. Molecular mechanisms involved in the toxicity of ortho-phenylphenol and its sodium salt
34. Biochemical factors involved in the effects of orthophenylphenol (OPP) and sodium orthophenylphenate (SOPP) on the urinary tract of male F344 rats
35. SAS/STAT User's Guide
36. Urinary physiologic and chemical metabolic effects on the urothelial cytotoxicity and potential DNA adducts of o-phenylphenol in male rats
37. DNA adduct formation by o-phenylphenol metabolite in vivo and in vitro
38. Technical grade ortho-phenylphenol: A combined chronic toxicity/ oncogenicity testing study in the rat